Abstract:
:Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras-mediated transformation. We identified a novel potent inhibitor of Ras-mediated morphological transformation encoded by a truncated version of the receptor for activated C-kinase (RACK1). The truncated protein, designated RACK1DeltaWD1, lacked the N-terminal 49 amino acids encoding the first of the 7 WD40 repeats in RACK1. RACK1DeltaWD1 expression restored contact inhibition, stress fiber formation and reduced ERK phosphorylation in Ki-Ras transformed NIH 3T3 cells. We demonstrate that truncated RACK1 is involved in complexes consisting of wild-type RACK1 and protein kinase C isoforms alpha, betaI and delta, compromising the transduction of an activated Ras signal to the Raf-MEK-ERK pathway. The cellular localization of RACK1DeltaWD1 differed from wtRACK1, indicating that signaling complexes containing the truncated version of RACK1 are incorrectly localized. Notably, 12-O-tetradecanoyl-13-phorbol acetate (TPA) mediated intracellular translocation of RACK1-interacting PKC alpha and delta was abrogated in RACK1DeltaWD1-expressing cells. Our data support a model where RACK1 acts as a key factor in Ki-Ras-mediated morphological transformation.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Bjørndal B,Myklebust LM,Rosendal KR,Myromslien FD,Lorens JB,Nolan G,Bruland O,Lillehaug JRdoi
10.1002/ijc.22373subject
Has Abstractpub_date
2007-03-01 00:00:00pages
961-9issue
5eissn
0020-7136issn
1097-0215journal_volume
120pub_type
杂志文章abstract::Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
abstract::AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...
journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220114
更新日期:1978-07-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.29166
更新日期:2015-03-15 00:00:00
abstract::Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-alpha over-expression and its role in the 5-methyltetrahydrofolic acid (N5-CH3-H4PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC), the other k...
journal_title:International journal of cancer
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更新日期:1998-01-05 00:00:00
abstract::Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridizati...
journal_title:International journal of cancer
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更新日期:2011-01-01 00:00:00
abstract::Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30427
更新日期:2017-01-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2008-04-01 00:00:00
abstract::Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.25887
更新日期:2011-11-01 00:00:00
abstract::Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30774
更新日期:2017-08-15 00:00:00
abstract::Leukocyte-transforming agents were isolated in baboon leukocytes inoculated with oral excretions from immunosuppressed chimpanzees. The transformed lymphoblasts had B cell surface markers and harbored herpes-type virus particles; 5-10% of the cells contained cytoplasmic antigens reactive with Epstein-Barr virus (EBV)-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200318
更新日期:1977-09-15 00:00:00
abstract::A study was made on the effect of ovariectomy, 17 beta-oestradiol, and tamoxifen on the oestrogen and progesterone receptor-positive T61 human breast carcinoma grown in nude mice. The effect of the treatment was evaluated by the specific growth delay calculated on the basis of Gompertz growth curves, and by the change...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910350110
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journal_title:International journal of cancer
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更新日期:2011-07-01 00:00:00
abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32424
更新日期:2020-01-15 00:00:00
abstract::Quality of life outcomes provide essential information for patients and physicians in oncology care. However, the validity of progression-free survival (PFS) as a surrogate for quality of life, and the inclusion and reporting of quality of life endpoints in clinical trials, is unclear. We performed a retrospective stu...
journal_title:International journal of cancer
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doi:10.1002/ijc.31957
更新日期:2019-04-01 00:00:00
abstract::Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...
journal_title:International journal of cancer
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doi:10.1002/ijc.23242
更新日期:2008-03-15 00:00:00
abstract::Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-03-10 00:00:00
abstract::Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...
journal_title:International journal of cancer
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更新日期:2007-02-01 00:00:00
abstract::Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...
journal_title:International journal of cancer
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更新日期:2019-09-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1997-10-09 00:00:00
abstract::No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) accordi...
journal_title:International journal of cancer
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更新日期:2012-07-15 00:00:00
abstract::The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...
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abstract::Dendritic cells (DCs) and natural killer (NK) cells are key players at the interface between innate resistance and acquired immunity. NK cells can induce DC maturation, a differentiation process whereby DCs respond to a environmental stimulus and acquire the ability of eliciting adaptive immunity. Conversely, maturing...
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abstract::In addition to antiviral effects, Type I interferons (IFN) have potent antiproliferative and immunomodulatory activities. Because of these properties IFNs have been evaluated as therapeutics for the treatment of a number of human diseases, including cancer. Currently, IFNs have been shown to be efficacious for the tre...
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