A portion of the feline leukaemia virus genome is not endogenous in cat cells.

Abstract:

:Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) transcript with normal cat liver DNA. The recycled cDNA hybridized well with the cellular DNA of virus-infected cells, but to a lesser extent with DNA from uninfected cat cells. The probe was used to differentiate virus-positive from virus-negative tumour tissues of cats. The same approach with cDNA of another endogenous feline virus, RD114, failed to show any difference between a virus-infected cell line and normal cells, including both virus-inducible and non-inducible lines.

journal_name

Int J Cancer

authors

Okabe H,DuBuy J,Gilden RV,Gardner MB

doi

10.1002/ijc.2910220114

subject

Has Abstract

pub_date

1978-07-15 00:00:00

pages

70-8

issue

1

eissn

0020-7136

issn

1097-0215

journal_volume

22

pub_type

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