Characteristic patterns of HOX gene expression in different types of human leukemia.

abstract：:We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...

journal_title：International journal of cancer

authors： Frisan T,Nagy N,Chioureas D,Terol M,Grasso F,Masucci MG

更新日期：2019-01-01 00:00:00

abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...

journal_title：International journal of cancer

authors： Baade PD,Whiteman DC,Janda M,Cust AE,Neale RE,Smithers BM,Green AC,Khosrotehrani K,Mar V,Soyer HP,Aitken JF

更新日期：2020-09-01 00:00:00

abstract：:The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...

journal_title：International journal of cancer

authors： Wei L,Xu Z

更新日期：2011-07-15 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

journal_title：International journal of cancer

authors： Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

更新日期：2007-02-01 00:00:00

abstract：:The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with...

journal_title：International journal of cancer

authors： Mahmoud LA,Robinson WA

更新日期：1982-08-15 00:00:00

abstract：:Natural killer (NK) cells exhibit strong cytotoxic activity against tumor cells without prior sensitization, and have the potential to exert antibody-dependent cellular cytotoxicity (ADCC). In this clinical trial, we examined the safety and efficacy of the use of NK cells, generated using a novel expansion system, in ...

journal_title：International journal of cancer

authors： Ishikawa T,Okayama T,Sakamoto N,Ideno M,Oka K,Enoki T,Mineno J,Yoshida N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Konishi H,Kokura S,Uno K,Naito Y,Itoh Y

更新日期：2018-06-15 00:00:00

abstract：:This paper deals with a spontaneous malignant transformation in one of our XP fibroblast lines. This cell line, designated XP29MA, was derived from a 14-year-old boy who did not show skin tumors or precancerous alterations either at the time of clinical examination or when the biopsy was taken. We have compared the fo...

journal_title：International journal of cancer

authors： Thielmann HW,Fischer E,Dzarlieva RT,Komitowski D,Popanda O,Edler L

更新日期：1983-06-15 00:00:00

abstract：:The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...

journal_title：International journal of cancer

authors： Kageshita T,Hirai S,Ono T,Ferrone S

更新日期：1995-01-27 00:00:00

abstract：:Alterations in TGF-beta signaling appear to be associated with an altered risk of developing cancer, including breast cancer. We carried out a case-control study on 8 polymorphisms, including 5 in the TGF-beta1 gene (G-800A, C-509T, Leu10-->Pro, Arg25-->Pro and Thr263-->Ile), a polyalanine polymorphism (9A-->6A) in th...

journal_title：International journal of cancer

authors： Jin Q,Hemminki K,Grzybowska E,Klaes R,Söderberg M,Zientek H,Rogozinska-Szczepka J,Utracka-Hutka B,Pamula J,Pekala W,Försti A

更新日期：2004-10-20 00:00:00

abstract：:We studied if bladder cancers respond to HAMLET (human alpha-lactalbumin made lethal to tumor cells) to establish if intravesical HAMLET application might be used to selectively remove cancer cells in vivo. Patients with nonmuscle invasive transitional cell carcinomas were included. Nine patients received 5 daily intr...

journal_title：International journal of cancer

authors： Mossberg AK,Wullt B,Gustafsson L,Månsson W,Ljunggren E,Svanborg C

更新日期：2007-09-15 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene...

journal_title：International journal of cancer

authors： Hori Y,Hori H,Yamada Y,Carrera CJ,Tomonaga M,Kamihira S,Carson DA,Nobori T

更新日期：1998-01-05 00:00:00

abstract：:Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

journal_title：International journal of cancer

authors： Huovinen R,Wärri A,Collan Y

更新日期：1993-10-21 00:00:00

abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

journal_title：International journal of cancer

authors： Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

更新日期：1991-04-22 00:00:00

abstract：:The MLN64 gene, which is localized in q12-q21 of the human chromosome 17, encodes a novel protein containing 2 distinct domains. At the N-terminal, MLN64 exhibits a potential trans-membrane region, while at the C-terminal, it shares homology with the F26F4.4 protein of Coenorhabditis elegans and the steroidogenic acut...

journal_title：International journal of cancer

authors： Moog-Lutz C,Tomasetto C,Régnier CH,Wendling C,Lutz Y,Muller D,Chenard MP,Basset P,Rio MC

更新日期：1997-04-10 00:00:00

abstract：:With low cure rates but increasing diverse treatment options that provide variable remission times, ovarian cancer is increasingly being recognized as a chronic disease. This reality indicates the need for a better understanding of factors influencing disease progression. In a previous global analysis of gene expressi...

journal_title：International journal of cancer

authors： Ouellet V,Le Page C,Guyot MC,Lussier C,Tonin PN,Provencher DM,Mes-Masson AM

更新日期：2006-11-01 00:00:00

abstract：:Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...

journal_title：International journal of cancer

authors： Sounni NE,Baramova EN,Munaut C,Maquoi E,Frankenne F,Foidart JM,Noël A

更新日期：2002-03-01 00:00:00

abstract：:Neuron-specific src mRNA, which is expressed in human brain tissue by alternative splicing, is associated with neural differentiation. Neuronal c-srcNI expression may be associated with the ability of neuroblastomas to mature; furthermore, c-srcN2 mRNA is induced in chemically differentiated neuroblastoma cells in vit...

journal_title：International journal of cancer

authors： Matsunaga T,Shirasawa H,Tanabe M,Ohnuma N,Kawamura K,Etoh T,Takahashi H,Simizu B

更新日期：1994-09-15 00:00:00

abstract：:HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

journal_title：International journal of cancer

authors： Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

更新日期：2009-12-01 00:00:00

abstract：:A Kunitz-type protease inhibitor, bikunin, downregulates expression of uPA and its receptor uPAR at the mRNA and protein levels in several types of tumor cells. Our recent work showed that, using a cDNA microarray analysis, pregnancy-associated plasma protein-A (PAPP-A) is a candidate bikunin target gene. To clarify h...

journal_title：International journal of cancer

authors： Tanaka Y,Kobayashi H,Suzuki M,Hirashima Y,Kanayama N,Terao T

更新日期：2004-04-10 00:00:00

abstract：:The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas th...

journal_title：International journal of cancer

authors： Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason K

更新日期：1982-11-15 00:00:00

abstract：:Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...

journal_title：International journal of cancer

authors： Murtola TJ,Karppa EK,Taari K,Talala K,Tammela TL,Auvinen A

更新日期：2016-06-15 00:00:00

abstract：:DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of ANLL; 4 GGT----GAT tr...

journal_title：International journal of cancer

authors： Senn HP,Trân-Thang C,Wodnar-Filipowicz A,Jiricny J,Fopp M,Gratwohl A,Signer E,Weber W,Moroni C

更新日期：1988-01-15 00:00:00

abstract：:Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

journal_title：International journal of cancer

authors： Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

更新日期：2013-10-15 00:00:00

abstract：:We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale Univer...

journal_title：International journal of cancer

authors： Charpin C,Tavassoli F,Secq V,Giusiano S,Villeret J,Garcia S,Birnbaum D,Bonnier P,Lavaut MN,Boubli L,Carcopino X,Iovanna J

更新日期：2012-08-01 00:00:00

abstract：:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

journal_title：International journal of cancer

authors： Kerbel RS,Pross HF,Leibovitz A

更新日期：1977-11-15 00:00:00

abstract：:Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) ...

journal_title：International journal of cancer

authors： Meyer P,Klaes R,Schmitt C,Boettger MB,Garbe C

更新日期：2003-08-10 00:00:00

abstract：:The growth properties of a human melanoma cell line (MeWo) and of a variant (MeWo-LC1) endowed with higher metastatic potential in nude mice were compared using hormonally-defined serum-free media. The two cell lines failed to arrest in G0 following serum deprivation, and responded to INS and MSA but not to EGF, PDGF ...

journal_title：International journal of cancer

authors： Sauvaigo S,Fretts RE,Riopelle RJ,Lagarde AE

更新日期：1986-01-15 00:00:00

abstract：:Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

journal_title：International journal of cancer

authors： Mirabello L,Troisi RJ,Savage SA

更新日期：2009-07-01 00:00:00

abstract：:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...

journal_title：International journal of cancer

authors： Gillespie GY,Jensen FC,Russell SW

更新日期：1978-02-15 00:00:00