Abstract:
:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of lines tested were adenocarcinoma of the adrenal cortex, colon, rectum, lung, liver, breast and kidney, and carcinomas of the uterine cervix, bladder and vulva. All lines were found to be consistently Fc receptor-negative, as assayed by rosette formation with sheep erythrocytes coated with subhemagglutinating amounts of anti-sheep erythrocyte antibodies, or bovine erythrocytes heavily coated with non-hemagglutinating anti-bovine erythrocyte antibodies. This is similar to results obtained with murine tumors: carcinomas are consistently Fc receptor-negative, while those lines which are Fc receptor-positive are invariably lymphoreticular in nature. The human carcinoma cell lines were also negative for complement (C3) receptors and spontaneous T and B rosette markers. It is proposed that, in most cases, rosette-forming cells found in primary human carcinomas are, as in the mouse or rat, representative of infiltrating non-malignant lymphoreticular cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kerbel RS,Pross HF,Leibovitz Adoi
10.1002/ijc.2910200505subject
Has Abstractpub_date
1977-11-15 00:00:00pages
673-9issue
5eissn
0020-7136issn
1097-0215journal_volume
20pub_type
杂志文章abstract::Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210119
更新日期:1978-01-15 00:00:00
abstract::We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and inf...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29823
更新日期:2016-02-15 00:00:00
abstract::EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230603
更新日期:1979-06-15 00:00:00
abstract::Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23904
更新日期:2009-01-01 00:00:00
abstract::Breast carcinomas were examined by the immunoperoxidase technique using antisera specific for lymphocyte subsets, monocytes, NK cells and major histocompatibility antigens (HLA-A, -B, -C; Ia-like). Sixty-four per cent of the patients had a moderate or strong mononuclear cell infiltration, 77% of the patients without m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350610
更新日期:1985-06-15 00:00:00
abstract::Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30017
更新日期:2016-06-15 00:00:00
abstract::A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3E cells transformed by GLI1 with the gene expression profile of Sonic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23929
更新日期:2009-01-01 00:00:00
abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25172
更新日期:2010-09-01 00:00:00
abstract::Hodgkin and Reed-Sternberg (H and RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such cells are found only in a minority of HD lesions. Very few data have so far been published on the cytogenetic abnormalities in HD. An analysis of unknown genetic aberrations has only...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990719)82:2<250::aid-ijc
更新日期:1999-07-19 00:00:00
abstract::In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990924)83:1<10::aid-ijc3
更新日期:1999-09-24 00:00:00
abstract::In this prospective study, the relationship between energy and fat consumption and the risk of breast cancer was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age attended a health screening. The attendees were given a food-frequency questionnaire to be completed at home, and this was retu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630104
更新日期:1995-09-27 00:00:00
abstract::The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals tow...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290218
更新日期:1982-02-15 00:00:00
abstract::It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.20671
更新日期:2005-03-01 00:00:00
abstract::Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33451
更新日期:2021-01-04 00:00:00
abstract::Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, RASSF1A located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the status of RASSF1A in cervical cancers. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11051
更新日期:2003-06-10 00:00:00
abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28199
更新日期:2013-10-15 00:00:00
abstract::The aim of our study was to investigate the protection afforded to the bone marrow by Goralatide (AcSDKP), an inhibitor of hemopoietic stem cell proliferation, when administered alone or in combination with a growth factor (granulocyte/macrophage colony-stimulating factor [GM-CSF]) during iterative cycles of Ara-C (cy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980330)76:1<38::aid-ijc8
更新日期:1998-03-30 00:00:00
abstract::Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27448
更新日期:2012-10-15 00:00:00
abstract::Three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (Papio hamadryas) by co-cultivation of the lymphocytes with X-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. A herpesvirus, associa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180611
更新日期:1976-12-15 00:00:00
abstract::Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30677
更新日期:2017-06-01 00:00:00
abstract::Various angiogenesis-related self-molecules have been considered to be therapeutic targets. However, the direct use of self-molecules as vaccines is not recommended because of the inherent ability of the host to develop immune tolerance. Antigen 43 (Ag43) is a surface protein found in E. coli and contains an α and a β...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28511
更新日期:2014-04-15 00:00:00
abstract::The reported beverage habits of 569 lung cancer patients and 569 control patients admitted to Roswell Park Memorial Institute (RPMI) were studied, 355 male cases and 214 female cases being matched to controls within strata of age and residence. Smoking history and an index of vitamin A from vegetables had significant,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430412
更新日期:1989-04-15 00:00:00
abstract::A loss of chromosome-9 material is one of the most frequent genomic aberrations known in bladder cancer. In order to better understand the role of chromosome-9 losses in bladder cancer, 125 formalin-fixed and 37 unfixed bladder tumors were examined using fluorescence in situ hybridization (FISH). A repetitive probe fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640205
更新日期:1995-04-21 00:00:00
abstract::Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23774
更新日期:2008-11-15 00:00:00
abstract::Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960822)69:4<340::AID-IJC
更新日期:1996-08-22 00:00:00
abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570505
更新日期:1994-06-01 00:00:00
abstract::It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29102
更新日期:2015-03-15 00:00:00
abstract::Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...
journal_title:International journal of cancer
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更新日期:2020-08-01 00:00:00
abstract::The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440526
更新日期:1989-11-15 00:00:00
abstract::Three human ovarian cancer xenografts of different origin and grown s.c. in nude mice as well-established tumors were studied for their sensitivity to cisplatin (CDDP), cyclophosphamide (CTX), 131I-labelled anti-episialin monoclonal antibody (MAb) 139H2, or external-beam radiotherapy. The maximum tolerated dose of CDD...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510120
更新日期:1992-04-22 00:00:00