Abstract:
:The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas the malignant cell lines, with one exception, secreted both enzymes. Therefore, the secretion of BM collagenase appears to be a characteristic of many malignant cells whereas PA is synthesized also by normal cells. The BM collagenase needed proteolytic activation for maximal activity indicating that it is secreted in a latent form. The addition of plasminogen to the culture medium of human fibrosarcoma cells (HT-1080) resulted in maximal activation of the enzyme. Plasmin, but not plasminogen, increased the activity of partially purified enzyme protein. Accordingly, the activation of latent BM collagenase in vivo may be facilitated by PA through the conversion of plasminogen to plasmin. It is suggested that the secretion of BM collagenase concomitantly with PA is a prerequisite for metastasis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason Kdoi
10.1002/ijc.2910300520subject
Has Abstractpub_date
1982-11-15 00:00:00pages
669-73issue
5eissn
0020-7136issn
1097-0215journal_volume
30pub_type
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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