Abstract:
:Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies (MAbs) to monomorphic framework determinants of HLA sublocus products, beta 2m and Ii, and to CD53, a recently defined broadly distributed pan-leucocyte molecule. Compared with the normal state, an induction/neo-expression of HLA-A,B,C/beta 2m was found in a considerable number of tumors of muscle, peripheral nerve, cartilage-forming, adipose, and vascular tissues. Conversely, some tumors of fibrous origin and of autonomic ganglia showed an abnormal abrogation/loss of HLA-A,B,C/beta 2m with respect to their cells of origin. Small, round tumor cells present in various types of STT exhibited a heterogenous pattern of expression of these molecules with a preponderance of HLA-A, B,C/beta 2m-negativity. HLA-D/Ii determinants were rarely detectable in STT. Besides their expression in some fibrohistiocytic tumors, they were only occasionally found in tumors of smooth-muscle, peripheral-nerve and vascular origin as well as in one clear-cell sarcoma. In all tumors but one, there was no microtopographic association between HLA-D/Ii-positive tumor cells and inflammatory cells. CD53 allowed discrimination between dendritic interstitial cells (DIC) and neoplastic cells and additionally revealed that, in contrast to other solid tumors, STT are generally characterized by an extreme scarcity of lymphohistiocytic infiltrates. Our data indicate that, aside from very rare exceptions, aberrant induction or abrogation of MHC molecules in STT occurs in the absence of lymphohistiocytic stromal infiltrates, suggesting that these alterations might not be a consequence of local cytokine effects.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mechtersheimer G,Staudter M,Majdic O,Dörken B,Moldenhauer G,Möller Pdoi
10.1002/ijc.2910460512subject
Has Abstractpub_date
1990-11-15 00:00:00pages
813-23issue
5eissn
0020-7136issn
1097-0215journal_volume
46pub_type
杂志文章abstract::The predictive effect of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) treatment is still highly discussed. The primary objective of our study was to investigate a possible prognostic/predictive value of ctDNA under regorafenib treatment. This prospective multicenter translational biomarker phase II pilot s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33303
更新日期:2021-03-15 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33123
更新日期:2020-10-15 00:00:00
abstract::Occupational exposures were assessed in a case-control study on testicular cancer using self-administered questionnaires. In total, answers were obtained for 148 (91%) cases and 315 (87%) controls. Of the cases, 101 had seminoma and 47 had embryonal testicular cancer. An increased odds ratio (OR) was found for exposur...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971210)73:6<828::aid-ijc
更新日期:1997-12-10 00:00:00
abstract::Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370313
更新日期:1986-03-15 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00
abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280103
更新日期:1981-07-15 00:00:00
abstract::The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000715)87:2<295::aid-ijc23>3.0
更新日期:2000-07-15 00:00:00
abstract::The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450614
更新日期:1990-06-15 00:00:00
abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19981029)78:3<293::AID-IJC
更新日期:1998-10-29 00:00:00
abstract::The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170515
更新日期:1976-05-15 00:00:00
abstract::We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present study, we have found that this difference in expression is part...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24797
更新日期:2010-03-15 00:00:00
abstract::A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21145
更新日期:2005-10-20 00:00:00
abstract::Chile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23662
更新日期:2008-09-15 00:00:00
abstract::Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20245
更新日期:2004-08-20 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25367
更新日期:2011-02-01 00:00:00
abstract::Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29401
更新日期:2015-07-15 00:00:00
abstract::Data from a hospital-based matched case-control study with 531 male pairs were analyzed for risks of cancer of the lower urinary tract associated with previous employment and particular occupational exposures. Statistically significant odds ratios were obtained for ever-employment as mining workers (2.0), turners (2.3...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410309
更新日期:1988-03-15 00:00:00
abstract::The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980821)79:4<376::aid-ijc
更新日期:1998-08-21 00:00:00
abstract::We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530615
更新日期:1993-04-01 00:00:00
abstract::Erythropoietin (Epo) regulates erythropoiesis by binding to its receptor (EpoR) and promoting cell proliferation, differentiation and inhibition of apoptosis. Epo is widely used to treat cervical cancer-related anaemia. However, there are data suggesting that administration of Epo is associated with an increment in re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25935
更新日期:2011-12-01 00:00:00
abstract::Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33209
更新日期:2021-01-15 00:00:00
abstract::AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330121
更新日期:1984-01-15 00:00:00
abstract::We studied plasmin receptors on 3 MCF-7 sublines: MCF7, MCF7R which was derived by transfection with v-Ha-ras oncogene, and MCF7MF which has been studied for the secretion of procathepsin D in the presence of estrogen. All 3 sublines bound plasmin (Pli) with a much higher affinity than plasminogen (Pg). The number of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460432
更新日期:1990-10-15 00:00:00
abstract::Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25635
更新日期:2011-06-15 00:00:00
abstract::The aim of our study was to further explore the use of anti-angiogenic therapy targeting the vascular endothelial growth factor receptor (VEGFR) on endothelial cells while simultaneously targeting platelet-derived growth factor receptors (PDGFRs) on adjacent pericytes. B16 mouse melanoma tumors exogenously expressing ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22999
更新日期:2007-12-15 00:00:00
abstract::One hundred patients with Ph1-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph1 chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bone-marrow cells. Our study suggests that ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410609
更新日期:1988-06-15 00:00:00
abstract::In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990924)83:1<10::aid-ijc3
更新日期:1999-09-24 00:00:00
abstract::Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31299
更新日期:2018-07-01 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270616
更新日期:1981-06-15 00:00:00