Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.

abstract：:Data from an international case-control study of breast cancer that was conducted in the 1960s were used to examine whether multiple births affect the risk of breast cancer in the mother. Among 2821 parous breast-cancer patients, 88 had had one or more multiple births, whereas among 8882 controls 247 had had one or mo...

journal_title：International journal of cancer

authors： Hsieh CC,Goldman M,Pavia M,Ekbom A,Petridou E,Adami HO,Trichopoulos D

更新日期：1993-04-22 00:00:00

abstract：:The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

journal_title：International journal of cancer

authors： Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

更新日期：2012-09-15 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...

journal_title：International journal of cancer

authors： Eskelinen M,Lipponen P,Aitto-Oja L,Hall O,Syrjänen K

更新日期：1993-10-21 00:00:00

abstract：:The Japanese have a much lower incidence of nonmelanoma skin cancers (NMSCs) than Caucasians, presumably due in part to their skin type conferring relative protection from ultraviolet light radiation (UVR). To examine the contribution of environmental or endogenous mutagens other than UVR, which are expected to be rel...

journal_title：International journal of cancer

authors： Takata M,Rehman I,Rees JL

更新日期：1997-05-02 00:00:00

abstract：:The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...

journal_title：International journal of cancer

authors： Takata M,Morita R,Takehara K

更新日期：2000-02-15 00:00:00

abstract：:Data from 1,916 cases of oral neoplasms occurring in the Sudan in a 16-year period, from January 1970 to December 1985, were retrieved and analysed. The study revealed a relatively high frequency of oral neoplasms in comparison with neighbouring countries. In this study, squamous-cell carcinoma was the most common ora...

journal_title：International journal of cancer

authors： Idris AM,Ahmed HM,Mukhtar BI,Gadir AF,el-Beshir EI

更新日期：1995-04-10 00:00:00

abstract：:Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...

journal_title：International journal of cancer

authors： Cullinan N,Villani A,Mourad S,Somers GR,Reichman L,van Engelen K,Stephens D,Weksberg R,Foulkes WD,Malkin D,Grant R,Goudie C

更新日期：2020-02-15 00:00:00

abstract：:The mutated in colorectal cancer (MCC) is a multifunctional gene showing loss of expression in colorectal and liver cancers. MCC mutations can drive colon carcinogenesis in the mouse and in vitro experiments suggest that loss of MCC function promotes cancer through several important cellular pathways. In particular, t...

journal_title：International journal of cancer

authors： Pangon L,Mladenova D,Watkins L,Van Kralingen C,Currey N,Al-Sohaily S,Lecine P,Borg JP,Kohonen-Corish MR

更新日期：2015-01-01 00:00:00

abstract：:This report describes maternal and perinatal risk factors for Wilms' tumor analyzed in a case-control study nested in a nationwide cohort in Sweden. The Swedish National Cancer Registry ascertained 110 cases from among successive birth cohorts from 1973 through 1984, identified by the Swedish Medical Birth Registry, t...

journal_title：International journal of cancer

authors： Lindblad P,Zack M,Adami HO,Ericson A

更新日期：1992-04-22 00:00:00

abstract：:Data on the incidence of 15 cancers in the Jewish population of Israel from the period 1961-1981 have been studied with emphasis on the risk of disease in relation to birthplace, calendar time, and duration of residence in Israel. The results show wide variations in incidence by birthplace, from less than 2-fold for p...

journal_title：International journal of cancer

authors： Parkin DM,Steinitz R,Khlat M,Kaldor J,Katz L,Young J

更新日期：1990-04-15 00:00:00

abstract：:In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

journal_title：International journal of cancer

authors： Allday MJ,Kundu D,Finerty S,Griffin BE

更新日期：1990-06-15 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to assess the diagnostic performance of breast imaging in the diagnosis of breast cancer in a non-screening population. In a consecutive set of patients referred for mammography in one year, the results of palpation and radiological breast imaging were scored on a 5-point grading scale and li...

journal_title：International journal of cancer

authors： Flobbe K,van der Linden ES,Kessels AG,van Engelshoven JM

更新日期：2001-05-15 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (CDDP) induced G2-phase arrest in PC-9 human cancer cells. To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as p34cdc2 protein kinase. p34cdc2 protein kinase activity was maximum in G2 phase and decreased after G2/M trans...

journal_title：International journal of cancer

authors： Nishio K,Fujiwara Y,Miyahara Y,Takeda Y,Ohira T,Kubota N,Ohta S,Funayama Y,Ogasawara H,Ohata M

更新日期：1993-10-21 00:00:00

abstract：:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

journal_title：International journal of cancer

authors： Hawkins MM,Smith RA

更新日期：1989-03-15 00:00:00

abstract：:Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...

journal_title：International journal of cancer

authors： Tveit KM,Fodstad O,Olsnes S,Pihl A

更新日期：1980-12-15 00:00:00

abstract：:XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA -4G>A polymorphism was identified in the 5' noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA ...

journal_title：International journal of cancer

authors： Ding D,Zhang Y,Yu H,Guo Y,Jiang L,He X,Ma W,Zheng W

更新日期：2012-07-15 00:00:00

abstract：:The role of the mismatch repair (MMR) system in correcting base-base mismatches is well established; its involvement in the response to DNA double strand breaks, however, is less clear. We investigated the influence of the essential component of MMR, the hMLH1 protein, on the cellular response to DNA-double strand bre...

journal_title：International journal of cancer

authors： Bhonde MR,Hanski ML,Stehr J,Jebautzke B,Peiró-Jordán R,Fechner H,Yokoyama KK,Lin WC,Zeitz M,Hanski C

更新日期：2010-06-15 00:00:00

abstract：:The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

journal_title：International journal of cancer

authors： Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

更新日期：2002-02-01 00:00:00

abstract：:Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

journal_title：International journal of cancer

authors： Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

更新日期：1992-07-30 00:00:00

abstract：:TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of...

journal_title：International journal of cancer

authors： Zenz T,Kreuz M,Fuge M,Klapper W,Horn H,Staiger AM,Winter D,Helfrich H,Huellein J,Hansmann ML,Stein H,Feller A,Möller P,Schmitz N,Trümper L,Loeffler M,Siebert R,Rosenwald A,Ott G,Pfreundschuh M,Stilgenbauer S,Ger

更新日期：2017-10-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is frequently expressed in triple-negative breast cancer (TNBC) and is a marker of poor prognosis in this patient population. Because activating mutations in this kinase are very rare events in breast cancer, we screened breast tumor gene expression profiles to examine the d...

journal_title：International journal of cancer

authors： Giricz O,Calvo V,Peterson EA,Abouzeid CM,Kenny PA

更新日期：2013-12-01 00:00:00

abstract：:We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...

journal_title：International journal of cancer

authors： Eriksson M,Hardell L,Carlberg M,Akerman M

更新日期：2008-10-01 00:00:00

abstract：:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...

journal_title：International journal of cancer

authors： Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL

更新日期：1995-03-16 00:00:00

abstract：:Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose se...

journal_title：International journal of cancer

authors： Stepien M,Keski-Rahkonen P,Kiss A,Robinot N,Duarte-Salles T,Murphy N,Perlemuter G,Viallon V,Tjønneland A,Rostgaard-Hansen AL,Dahm CC,Overvad K,Boutron-Ruault MC,Mancini FR,Mahamat-Saleh Y,Aleksandrova K,Kaaks R,Kühn T,

更新日期：2021-02-01 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

journal_title：International journal of cancer

authors： Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

更新日期：2013-11-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...

journal_title：International journal of cancer

authors： Schmitt FC,Soares R,Gobbi H,Milanezzi F,Santos-Silva F,Cirnes L,Costa C,Seruca R

更新日期：1999-08-27 00:00:00