Effect on breast cancer mortality of biennial mammographic screening of women under age 50.


:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the end of 1990, 75 women had died of breast cancer out of the 332 cases diagnosed after the start of the screening project. Women from the same birth cohort, living in Arnhem, a neighbouring city with a comparable population and without a screening project, were used as controls. In this city, 74 breast cancer deaths out of 284 cases occurred during the same period. In Nijmegen, after 16 years of follow-up, breast cancer mortality showed a non-significant reduction of 6% (95% confidence interval: 32% reduction, 29% excess). In the relevant period, after a time lag of 10 years from the start of the programme, this reduction rose to 20% (95% confidence interval: 48% reduction, 23% excess). No reduction in breast cancer mortality was observed in the first decade of screening. For a later period, a shift towards a reduction emerges, but the data are as yet inconclusive.


Int J Cancer


Peer PG,Werre JM,Mravunac M,Hendriks JH,Holland R,Verbeek AL




Has Abstract


1995-03-16 00:00:00












  • Folate intake and colorectal cancer risk: a meta-analytical approach.

    abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJ

    更新日期:2005-02-20 00:00:00

  • Effects of recombinant human tumor necrosis factor-alpha on the surface phenotype and the growth of human malignant glioma cell lines.

    abstract::Human malignant glioma cell lines and clones were incubated with various concentrations of recombinant human TNF-alpha, either alone or in combination with recombinant human IFN-gamma. The surface expression of HLA-ABC (class I) antigens and beta 2-microglobulin, was significantly enhanced by TNF-alpha alone on every ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zuber P,Accolla RS,Carrel S,Diserens AC,de Tribolet N

    更新日期:1988-11-15 00:00:00

  • Trends in childhood acute lymphoblastic leukemia in Western Australia, 1960-2006.

    abstract::Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

    更新日期:2008-03-01 00:00:00

  • Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.

    abstract::The calcium-sensing receptor (CaSR) is suggested to mediate the antiproliferative effects of calcium in colon. However, in colorectal cancer (CRC) the expression of the CaSR is silenced and the underlying mechanisms leading to its loss are poorly understood. We investigated whether loss of the CaSR expression in color...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fetahu IS,Höbaus J,Aggarwal A,Hummel DM,Tennakoon S,Mesteri I,Baumgartner-Parzer S,Kállay E

    更新日期:2014-11-01 00:00:00

  • Circulating perivascular progenitors: a target of PDGFR inhibition.

    abstract::Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

    更新日期:2011-09-15 00:00:00

  • Smoking and the risk of endometrial cancer: results from the Nurses' Health Study.

    abstract::An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Viswanathan AN,Feskanich D,De Vivo I,Hunter DJ,Barbieri RL,Rosner B,Colditz GA,Hankinson SE

    更新日期:2005-05-10 00:00:00

  • Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: relation to tumor development and progression.

    abstract::The second most common target of prostate-cancer metastasis is bone, and the phenomenon of skeletal metastasis represents the incurable stage of disease. Histologically, skeletal metastasis from prostate cancer is distinctive due to its osteoblastic nature. The osteoblastic bone metastasis shows extensive new bone for...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thomas R,True LD,Lange PH,Vessella RL

    更新日期:2001-07-01 00:00:00

  • A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival.

    abstract::For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sharbi-Yunger A,Grees M,Cafri G,Bassan D,Eichmüller SB,Tzehoval E,Utikal J,Umansky V,Eisenbach L

    更新日期:2019-02-15 00:00:00

  • Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma.

    abstract::Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ellinger J,Kahl P,Mertens C,Rogenhofer S,Hauser S,Hartmann W,Bastian PJ,Büttner R,Müller SC,von Ruecker A

    更新日期:2010-11-15 00:00:00

  • Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.

    abstract::Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. Cytogenetic studies have indicated that deletions and unbalanced translocations involving chromosome 1 short arm material occur in 40% of the investigated cases. Recurrent chromosomal imbalances detected by comparative genomic hybridiza...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Van Gele M,Leonard JH,Van Roy N,Van Limbergen H,Van Belle S,Cocquyt V,Salwen H,De Paepe A,Speleman F

    更新日期:2002-09-10 00:00:00

  • Analysis of T-cell-receptor beta-chain-gene usage in peripheral-blood and tumor-infiltrating lymphocytes from human non-small-cell lung carcinomas.

    abstract::Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

    更新日期:1999-04-12 00:00:00

  • Synthesis of a nickel tetracarboranylphenylporphyrin for boron neutron-capture therapy: biodistribution and toxicity in tumor-bearing mice.

    abstract::Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram bod...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miura M,Micca PL,Fisher CD,Heinrichs JC,Donaldson JA,Finkel GC,Slatkin DN

    更新日期:1996-09-27 00:00:00

  • Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada.

    abstract::In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, respon...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghadirian P,Simard A,Baillargeon J,Maisonneuve P,Boyle P

    更新日期:1991-01-02 00:00:00

  • Enhanced expression of human T-cell leukemia/lymphoma virus in neoplastic T cells induced to proliferate by phorbol ester and interleukin-2.

    abstract::Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vyth-Dreese FA,de Vries JE

    更新日期:1983-07-15 00:00:00

  • Risk of lung cancer among cigarette and pipe smokers in southern China.

    abstract::Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other method...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

    更新日期:1992-05-28 00:00:00

  • Counteracting effects of dexamethasone and alpha 2-macroglobulin on inhibition of proliferation of normal and neoplastic rat hepatocytes by transforming growth factors-beta type 1 and type 2.

    abstract::Primary cultures of hepatocytes isolated from normal F-344 rats or from F-344 rats with hepatocellular carcinomas generated by a 2-step model of chemical carcinogenesis were used to determine if dexamethasone (DEX) or alpha 2-macroglobulin (alpha 2M) modify the ability of transforming growth factors-beta type I (TGF-b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wollenberg GK,LaMarre J,Semple E,Farber E,Gauldie J,Hayes MA

    更新日期:1991-01-21 00:00:00

  • Syngeneic in vivo passage of the murine BW 5147 lymphoma results in the expression of a stable metastatic phenotype.

    abstract::BW 5147 lymphoma cells are non-invasive tumor cells which do not generate experimental metastases following i.v. inoculation. In contrast, s.c. and intra-splenic (i.s.) growth of BW cells resulted in widespread colonization of liver and spleen. Cells derived from either s.c. tumors or metastatic lesions did generate m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Baetselier P,Roos E,van Hecke D,Verschaeve L,Brys L,Verschueren H

    更新日期:1988-05-15 00:00:00

  • Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma.

    abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fest S,Soldati R,Christiansen NM,Zenclussen ML,Kilz J,Berger E,Starke S,Lode HN,Engel C,Zenclussen AC,Christiansen H

    更新日期:2016-04-15 00:00:00

  • MicroRNA alterations in head and neck squamous cell carcinoma.

    abstract::MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

    更新日期:2008-12-15 00:00:00

  • Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma.

    abstract::The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jacobsen B,Santoni-Rugiu E,Illemann M,Kriegbaum MC,Laerum OD,Ploug M

    更新日期:2012-06-01 00:00:00

  • Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome.

    abstract::Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

    更新日期:2009-10-01 00:00:00

  • Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract.

    abstract::The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Malden LT,Novak U,Burgess AW

    更新日期:1989-03-15 00:00:00

  • Cancer-associated mis-sense and deletion mutations impair p16INK4 CDK inhibitory activity.

    abstract::The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lilischkis R,Sarcevic B,Kennedy C,Warlters A,Sutherland RL

    更新日期:1996-04-10 00:00:00

  • The clinical impact of using p16(INK4a) immunochemistry in cervical histopathology and cytology: an update of recent developments.

    abstract::Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Bergeron C,Ronco G,Reuschenbach M,Wentzensen N,Arbyn M,Stoler M,von Knebel Doeberitz M

    更新日期:2015-06-15 00:00:00

  • Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma.

    abstract::Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen YM,Shiu JY,Tzeng SJ,Shih LS,Chen YJ,Lui WY,Chen PH

    更新日期:1998-03-02 00:00:00

  • Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients.

    abstract::Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall surv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koster R,Panagiotou OA,Wheeler WA,Karlins E,Gastier-Foster JM,Caminada de Toledo SR,Petrilli AS,Flanagan AM,Tirabosco R,Andrulis IL,Wunder JS,Gokgoz N,Patiño-Garcia A,Lecanda F,Serra M,Hattinger C,Picci P,Scotlandi K,

    更新日期:2018-04-15 00:00:00

  • Second primary tumors in patients with hereditary retinoblastoma: a register-based follow-up study, 1945-1994.

    abstract::The aim of this register-based follow-up study was to evaluate the long-term cumulative incidence of second primary tumors (SPT) among survivors of hereditary retinoblastoma, with special interest for the incidence of pineoblastoma in retinoblastoma patients born after 1970. The Dutch Retinoblastoma Register was compl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moll AC,Imhof SM,Bouter LM,Kuik DJ,Den Otter W,Bezemer PD,Koten JW,Tan KE

    更新日期:1996-08-07 00:00:00

  • Non-V600E BRAF mutations and EGFR signaling pathway in colorectal cancer.

    abstract::The Raf murine sarcoma viral oncogene homolog B (BRAFV600E ) mutation (MT) in metastatic colorectal cancer (CRC) is a well-known prognostic indicator and a negative predictive biomarker for antiepidermal growth factor receptor (EGFR) treatment. However, the clinical characteristics and significance of BRAFnon-V600E MT...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Osumi H,Shinozaki E,Wakatsuki T,Suenaga M,Ichimura T,Ogura M,Takahari D,Ooki A,Suzuki T,Ota Y,Nakayama I,Chin K,Miki Y,Yamaguchi K

    更新日期:2019-11-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Charpin C,Tavassoli F,Secq V,Giusiano S,Villeret J,Garcia S,Birnbaum D,Bonnier P,Lavaut MN,Boubli L,Carcopino X,Iovanna J

    更新日期:2012-08-01 00:00:00

  • Treatment of multi-focal colorectal carcinoma metastatic to the liver of immune-competent and syngeneic rats by hepatic artery infusion of oncolytic vesicular stomatitis virus.

    abstract::Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shinozaki K,Ebert O,Woo SL

    更新日期:2005-04-20 00:00:00