Abstract:
:Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in various lymphoid organs and was detectable 2-3 days after drug treatment. Differences in the levels of boosted activity among the lymphoid organs resulted when the route of administration was varied. The degree of augmentation was largely independent of the dose of pyran, but did vary among different strains of mice. Augmentation, moreover, was followed by a rapid decline by 5-7 days.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Santoni A,Puccetti P,Riccardi C,Herberman RB,Bonmassar Edoi
10.1002/ijc.2910240520subject
Has Abstractpub_date
1979-11-15 00:00:00pages
656-61issue
5eissn
0020-7136issn
1097-0215journal_volume
24pub_type
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journal_title:International journal of cancer
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更新日期:1996-09-27 00:00:00
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journal_title:International journal of cancer
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