Sister chromatid exchange and nasopharyngeal carcinoma.

abstract：:Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...

journal_title：International journal of cancer

authors： Kuczyk M,Machtens S,Stief C,Jonas U

更新日期：1999-12-10 00:00:00

abstract：:Alterations of gene expression in squamous cell carcinoma (SCC) cell lines derived from the larynx and keratinocytes derived from adjacent normal mucosa of the larynx have been studied using the mRNA differential display technique. Lane-to-lane comparison of reverse transcribed mRNA showed a strong repression of a 148...

journal_title：International journal of cancer

authors： Görögh T,Rudert H,Lippert BM,Gottschlich S,Maune S,Heidorn K,Maass J,Hoffmann M,Meyer JE,Rathcke IO,Folz BJ,Hortobagyi T,Werner JA

更新日期：1999-12-10 00:00:00

abstract：:Using a microarray technique, we found decorin to be underexpressed, but osteopontin (OPN) to be overexpressed, in esophageal squamous cell carcinoma (ESCC). This study aims to examine whether plasma decorin and OPN plus personal substances use (tobacco, alcohol and areca) can serve as suitable clinical markers to pre...

journal_title：International journal of cancer

authors： Wu IC,Wu DC,Huang CC,Lin HS,Chen YK,Tsai HJ,Lu CY,Chou SH,Chou YP,Li LH,Tai SY,Wu MT

更新日期：2010-11-01 00:00:00

abstract：:We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...

journal_title：International journal of cancer

authors： Kondo T,Kono H,Miyamoto N,Yoshida R,Toki H,Matsumoto I,Hara M,Inoue H,Inatsuki A,Funatsu T

更新日期：1989-06-15 00:00:00

abstract：:Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...

journal_title：International journal of cancer

authors： Fiegl H,Windbichler G,Mueller-Holzner E,Goebel G,Lechner M,Jacobs IJ,Widschwendter M

更新日期：2008-08-01 00:00:00

abstract：:Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...

journal_title：International journal of cancer

authors： Kramer RH,Gonzalez R,Nicolson GL

更新日期：1980-11-15 00:00:00

abstract：:ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C), the hydrolysis product of glucosinolates occurring in cruciferous ve...

journal_title：International journal of cancer

authors： Donald S,Verschoyle RD,Greaves P,Colombo T,Zucchetti M,Falcioni C,Zaffaroni M,D'Incalci M,Manson MM,Jimeno J,Steward WP,Gescher AJ

更新日期：2004-10-10 00:00:00

abstract：:Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its pathogenesis is essential to developing alternative therapeutic strategies. We previously demonstrated that the Wnt signaling pathway is activated in MPM through...

journal_title：International journal of cancer

authors： Mazieres J,You L,He B,Xu Z,Twogood S,Lee AY,Reguart N,Batra S,Mikami I,Jablons DM

更新日期：2005-11-01 00:00:00

abstract：:Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...

journal_title：International journal of cancer

authors： Meinl W,Pabel U,Osterloh-Quiroz M,Hengstler JG,Glatt H

更新日期：2006-03-01 00:00:00

abstract：:Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in premenopausal and postmenopausal women is unknown in most African countries. We used data from the African Cancer Regis...

journal_title：International journal of cancer

authors： Joko-Fru WY,Jedy-Agba E,Korir A,Ogunbiyi O,Dzamalala CP,Chokunonga E,Wabinga H,Manraj S,Finesse A,Somdyala N,Liu B,McGale P,Jemal A,Bray F,Parkin DM

更新日期：2020-10-15 00:00:00

abstract：:Paracrine motogenic cytokines secreted by normal cells can stimulate metastatic cell invasion. For example, human fibroblasts secrete hepatocyte growth factor/scatter factor (HGF/SF), which stimulates paracrine migration of epithelial and certain carcinoma cells, and migration-stimulating factor (MSF), which stimulate...

journal_title：International journal of cancer

authors： Hu M,Pollock RE,Nakamura T,Nicolson GL

更新日期：1995-09-04 00:00:00

abstract：:A new non peptidic farnesyltransferase inhibitor, RPR-115135, in combination with 5-FU was studied in 10 human colon cancer cell lines (HCT-116, RKO, DLD-1, Colo-320, LoVo, SW-620, HT-29, HCT-15, Colo-205 and KM-12) carrying several mutations but well characterized for p53 and Ras status. We found that there was a sli...

journal_title：International journal of cancer

authors： Russo P,Malacarne D,Falugi C,Trombino S,O'Connor PM

更新日期：2002-07-20 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:The ganglioside composition of 20 human malignant melanomas and 5 normal tissues (muscle, spleen, kidney, liver and brain) was analyzed by high-performance thin-layer chromatography (HPTLC) and immune HPTLC using a panel of antiganglioside monoclonal antibodies, and quantified by photodensitometry. The most prominent ...

journal_title：International journal of cancer

authors： Hamilton WB,Helling F,Lloyd KO,Livingston PO

更新日期：1993-02-20 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...

journal_title：International journal of cancer

authors： Qin N,de Cubas AA,Garcia-Martin R,Richter S,Peitzsch M,Menschikowski M,Lenders JW,Timmers HJ,Mannelli M,Opocher G,Economopoulou M,Siegert G,Chavakis T,Pacak K,Robledo M,Eisenhofer G

更新日期：2014-11-01 00:00:00

abstract：:A cytogenetic study, including prophase-prometaphase chromosome analysis, of a patient with EBV-genome-negative acute lymphocytic leukemia of B-cell type with Burkitt-type cells is presented. All bone-marrow mitoses examined had a 14q+ marker chromosome which was identified as a reciprocal 8;14 translocation of exactl...

journal_title：International journal of cancer

authors： Mitelman F,Andersson-Anvret M,Brandt L,Catovsky D,Klein G,Manolov G,Manolova Y,Mark-Vendel E,Nilsson PG

更新日期：1979-07-15 00:00:00

abstract：:Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

journal_title：International journal of cancer

authors： Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

更新日期：2006-06-01 00:00:00

abstract：:Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...

journal_title：International journal of cancer

authors： Wu WK,Wang G,Coffelt SB,Betancourt AM,Lee CW,Fan D,Wu K,Yu J,Sung JJ,Cho CH

更新日期：2010-10-15 00:00:00

abstract：:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

journal_title：International journal of cancer

authors： Kerbel RS,Pross HF,Leibovitz A

更新日期：1977-11-15 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

journal_title：International journal of cancer

authors： Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

更新日期：1999-03-01 00:00:00

abstract：:During natural metastasis, cancer cells are released continuously into the bloodstream and arrested in target organs; the process is repetitive rather than a single event. In this communication, the effect of preceding on successive "pulses" of cancer cells is discussed in relation to the arrest, retention and tumor f...

journal_title：International journal of cancer

authors： Ward PM,Weiss L

更新日期：1985-10-15 00:00:00

abstract：:Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

journal_title：International journal of cancer

authors： Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

更新日期：2008-11-01 00:00:00

abstract：:Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immu...

journal_title：International journal of cancer

authors： Schmiedel BJ,Arélin V,Gruenebach F,Krusch M,Schmidt SM,Salih HR

更新日期：2011-06-15 00:00:00

abstract：:Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...

journal_title：International journal of cancer

authors： Henle G,Henle W

更新日期：1976-01-15 00:00:00

abstract：:Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

journal_title：International journal of cancer

authors： de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

更新日期：2009-10-01 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...

journal_title：International journal of cancer

authors： Vose BM,Moore M,Jack GD

更新日期：1975-02-15 00:00:00

abstract：:Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...

journal_title：International journal of cancer

authors： Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

更新日期：2001-04-01 00:00:00

abstract：:We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...

journal_title：International journal of cancer

authors： Bashir I,Sikora K,Abel P,Foster CS

更新日期：1994-06-01 00:00:00