Abstract：
:The aim of this study was to assess the diagnostic performance of breast imaging in the diagnosis of breast cancer in a non-screening population. In a consecutive set of patients referred for mammography in one year, the results of palpation and radiological breast imaging were scored on a 5-point grading scale and linked to pathology as gold standard after a follow up period of one year. The diagnostic performance was studied by logistic regression analysis and ROC-curves. There were 1,944 breast examinations in 1,890 patients and 3,816 breasts. Pathology results reported 118 malignancies in 115 women. With a cut-off point between benign and uncertain benign a sensitivity of 89% and a specificity of 98% was found for radiological imaging. ROC-curves showed a significant increase in diagnostic performance when radiology was added to results of palpation and age (p = 0.007). Radiological imaging tests have a large diagnostic value in the detection of breast cancer in addition to palpation and age. A sensitivity close to 100% could be reached.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Flobbe K,van der Linden ES,Kessels AG,van Engelshoven JMdoi
10.1002/ijc.1235keywords:
subject
Has Abstractpub_date
2001-05-15 00:00:00pages
616-8issue
4eissn
0020-7136issn
1097-0215pii
10.1002/ijc.1235journal_volume
92pub_type
杂志文章abstract：:Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24347
更新日期：2009-08-15 00:00:00
abstract：:A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910360514
更新日期：1985-11-15 00:00:00
abstract：:Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19971127)73:5<707::aid-ijc
更新日期：1997-11-27 00:00:00
abstract：:Serum tyrosinase activity has been measured by adapting the [3]tyrosine assay for tyrosinase and significant elevations of serum tyrosinase activity were found in patients with malignant melanoma. In contrast to findings in a study which utilized [14C]tyrosine, augmented levels of tyrosinase activity were not observed...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200507
更新日期：1977-11-15 00:00:00
abstract：:The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450635
更新日期：1990-06-15 00:00:00
abstract：:CA 50 is a new tumor marker based on a monoclonal antibody (MAb) against a human colorectal carcinoma cell line. The CA 50 antigen is similar, but not identical, to the tumor marker CA 19-9. The serum concentrations of CA 50 were measured by an immunoradiometric assay (CA 50 IRMA) in 95 patients with pancreatic cancer...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910390412
更新日期：1987-04-15 00:00:00
abstract：:Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550520
更新日期：1993-11-11 00:00:00
abstract：:The European Study Group for Pancreatic Cancer (ESPAC-1) study is the largest study of adjuvant treatment for pancreatic ductal adenocarcinoma to date and confirmed a survival advantage for adjuvant chemotherapy but not for chemoradiation. The importance of parallel evaluation of survival and quality of life (QoL) has...
journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/ijc.24270
更新日期：2009-06-15 00:00:00
abstract：:MEK1/2 inhibitors like U0126 can potentiate or antagonize the antitumor activity of cytotoxic agents such as cisplatin, paclitaxel or vinblastine, depending on the drug or the target cells. We now investigated whether U0126, differentially regulates melanoma signaling in response to UV radiation or betulinic acid, a d...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21478
更新日期：2006-03-01 00:00:00
abstract：:Rabbit V2 carcinoma cells and normal rabbit skin fibroblasts produced cysteine proteinases with properties similar to those of purified rabbit liver cathepsin B. Both cell types secreted into the culture medium enzymes with an apparent Mr of 43,000, which reacted with synthetic substrates commonly used for cathepsin B...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910380520
更新日期：1986-11-15 00:00:00
abstract：:The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-08-20 00:00:00
abstract：:Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidan...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc
更新日期：1997-03-04 00:00:00
abstract：:The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DN...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23470
更新日期：2008-06-15 00:00:00
abstract：:The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910150612
更新日期：1975-06-15 00:00:00
abstract：:Data are limited regarding cancer risk in human immunodeficiency virus (HIV)-infected persons with modest immunosuppression, before the onset of acquired immunodeficiency syndrome (AIDS). For some cancers, risk may be affected by highly active antiretroviral therapy (HAART) widely available since 1996. We linked HIV/A...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23487
更新日期：2008-07-01 00:00:00
abstract：:We studied the effect of retinoids on the growth and differentiation of a cell line (U 343 MG-A) derived from a human malignant astrocytoma. Cultures treated with all-trans or 13-cis retinoic acid showed a dose-dependent inhibition of proliferation and a marked reduction in the mean cell number at the plateau phase of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910420319
更新日期：1988-09-15 00:00:00
abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....
journal_title：International journal of cancer
pub_type： 杂志文章,收录出版
doi：10.1002/ijc.20917
更新日期：2005-07-01 00:00:00
abstract：:Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910470405
更新日期：1991-02-20 00:00:00
abstract：:Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.31338
更新日期：2018-10-01 00:00:00
abstract：:Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22297
更新日期：2007-02-01 00:00:00
abstract：:Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21000
更新日期：2005-08-10 00:00:00
abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19971021)74:5<551::aid-ijc
更新日期：1997-10-21 00:00:00
abstract：:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC
更新日期：1996-01-26 00:00:00
abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970529)71:5<810::aid-ijc
更新日期：1997-05-29 00:00:00
abstract：:The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960410)66:2<249::AID-IJC
更新日期：1996-04-10 00:00:00
abstract：:Little research has been conducted on the long-term value of human papillomavirus (HPV) testing after conization. We investigated whether cytology adds to the value of a negative HPV test for long-term prediction of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). In addition, we compared risk of CIN2+ fol...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29673
更新日期：2015-12-15 00:00:00
abstract：:EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230603
更新日期：1979-06-15 00:00:00
abstract：:140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300507
更新日期：1982-11-15 00:00:00
abstract：:Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24172
更新日期：2009-04-15 00:00:00
abstract：:Double-label immunofluorescence was used to monitor basement-membrane composition and integrity in 22 human colon polyps, 36 adenocarcinomas and 2 metastases. Cryostat sections were stained with polyclonal anti-laminin anti-serum combined with monoclonal antibodies (MAbs) to all major basement-membrane components (lam...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910500412
更新日期：1992-02-20 00:00:00
