Serum CA 50 as a tumor marker in pancreatic cancer: a comparison with CA 19-9.

abstract：:In order to study the mechanisms responsible for resistance to CDDP, 5 human tumor cell lines were made resistant to CDDP by repeated in vitro exposures. After cloning it was found that the cell lines developed were between 3.3-fold and 17-fold more resistant to CDDP than the parental cell lines at the IC90. These lin...

journal_title：International journal of cancer

authors： Teicher BA,Holden SA,Herman TS,Sotomayor EA,Khandekar V,Rosbe KW,Brann TW,Korbut TT,Frei E 3rd

更新日期：1991-01-21 00:00:00

abstract：:Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...

journal_title：International journal of cancer

authors： Persson EC,Graubard BI,Evans AA,London WT,Weber JP,LeBlanc A,Chen G,Lin W,McGlynn KA

更新日期：2012-11-01 00:00:00

abstract：:It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...

journal_title：International journal of cancer

authors： Kohno H,Takahashi M,Yasui Y,Suzuki R,Miyamoto S,Kamanaka Y,Naka M,Maruyama T,Wakabayashi K,Tanaka T

更新日期：2007-08-01 00:00:00

abstract：:Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-scatter factor (HGF-SF) in this phenomenon. Markedly increased serum levels...

journal_title：International journal of cancer

authors： von Schweinitz D,Faundez A,Teichmann B,Birnbaum T,Koch A,Hecker H,Glüer S,Fuchs J,Pietsch T

更新日期：2000-01-15 00:00:00

abstract：:For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...

journal_title：International journal of cancer

authors： Sharbi-Yunger A,Grees M,Cafri G,Bassan D,Eichmüller SB,Tzehoval E,Utikal J,Umansky V,Eisenbach L

更新日期：2019-02-15 00:00:00

abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

journal_title：International journal of cancer

authors： Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

更新日期：2012-08-15 00:00:00

abstract：:Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, biosynthetic pathways should be upregulated during cell cyc...

journal_title：International journal of cancer

authors： Vizán P,Alcarraz-Vizán G,Díaz-Moralli S,Solovjeva ON,Frederiks WM,Cascante M

更新日期：2009-06-15 00:00:00

abstract：:A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...

journal_title：International journal of cancer

authors： Park SM,Li T,Wu S,Li WQ,Weinstock M,Qureshi AA,Cho E

更新日期：2017-05-01 00:00:00

abstract：:A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...

journal_title：International journal of cancer

authors： Thomas JA,Iliescu V,Crawford DH,Ellouz R,Cammoun M,de-Thé G

更新日期：1984-06-15 00:00:00

abstract：:To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...

journal_title：International journal of cancer

authors： Jares P,Nadal A,Fernández PL,Pinyol M,Hernández L,Cazorla M,Hernández S,Beà S,Cardesa A,Campo E

更新日期：1999-05-31 00:00:00

abstract：:A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK(...

journal_title：International journal of cancer

authors： Leoncini L,Lazzi S,Scano D,Mura A,Onida A,Massarelli G,Tosi P,Barbini P,Cevenini G,Massai MR,Pileri S,Falini B,Giordano A,Kraft R,Laissue JA,Cottier H

更新日期：2000-06-15 00:00:00

abstract：:Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicu...

journal_title：International journal of cancer

authors： Hayes HM Jr,Pendergrass TW

更新日期：1976-10-15 00:00:00

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...

journal_title：International journal of cancer

authors： van Dijk J,Uemura H,Beniers AJ,Peelen WP,Zegveld ST,Fleuren GJ,Warnaar SO,Oosterwijk E

更新日期：1994-01-15 00:00:00

abstract：:Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was obser...

journal_title：International journal of cancer

authors： Yu H,Harris RE,Kabat GC,Wynder EL

更新日期：1988-09-15 00:00:00

abstract：:Breast cancer is the leading cancer diagnosis and second most common cause of cancer deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from Africa and none on the survival differences by stage at diagnosis. Here, we estimate breast cancer survival within SSA by area, stage and count...

journal_title：International journal of cancer

authors： Joko-Fru WY,Miranda-Filho A,Soerjomataram I,Egue M,Akele-Akpo MT,N'da G,Assefa M,Buziba N,Korir A,Kamate B,Traore C,Manraj S,Lorenzoni C,Carrilho C,Hansen R,Finesse A,Somdyala N,Wabinga H,Chingonzoh T,Borok M,Chok

更新日期：2020-03-01 00:00:00

abstract：:We investigated the expression pattern of the breast cancer associated gene LIV-1 on mRNA and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the ...

journal_title：International journal of cancer

authors： Kasper G,Weiser AA,Rump A,Sparbier K,Dahl E,Hartmann A,Wild P,Schwidetzky U,Castaños-Vélez E,Lehmann K

更新日期：2005-12-20 00:00:00

abstract：:The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...

journal_title：International journal of cancer

authors： Lilischkis R,Sarcevic B,Kennedy C,Warlters A,Sutherland RL

更新日期：1996-04-10 00:00:00

abstract：:Cytological screening for cervical cancer is hampered by high false negative rates. Inter-observer reproducibility needs optimizing. The potential of p16(INK4a) as a biomarker for cervical lesions was examined in a study of liquid-based cytology (LBC), HPV DNA testing by MY09/MY11 consensus PCR and type-specific PCRs ...

journal_title：International journal of cancer

authors： Sahebali S,Depuydt CE,Segers K,Moeneclaey LM,Vereecken AJ,Van Marck E,Bogers JJ

更新日期：2004-03-01 00:00:00

abstract：:In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

journal_title：International journal of cancer

authors： Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

更新日期：2000-12-01 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...

journal_title：International journal of cancer

authors： Balasubramanian SP,Cox A,Cross SS,Higham SE,Brown NJ,Reed MW

更新日期：2007-09-01 00:00:00

abstract：:Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surroun...

journal_title：International journal of cancer

authors： Bauer AS,Nazarov PV,Giese NA,Beghelli S,Heller A,Greenhalf W,Costello E,Muller A,Bier M,Strobel O,Hackert T,Vallar L,Scarpa A,Büchler MW,Neoptolemos JP,Kreis S,Hoheisel JD

更新日期：2018-03-01 00:00:00

abstract：:We sought to analyze utilization and survival outcomes of cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (RCC) before and after introduction of targeted therapy. We identified patients with metastatic RCC between 1993 and 2010 in the SEER registry and examined temporal trends in utiliz...

journal_title：International journal of cancer

authors： Conti SL,Thomas IC,Hagedorn JC,Chung BI,Chertow GM,Wagner TH,Brooks JD,Srinivas S,Leppert JT

更新日期：2014-05-01 00:00:00

abstract：:In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis characterized by cell shrinkage and cell membrane scrambling. Eryptotic erythrocytes are rapidly cleared from circulating blood and may adhere to the vascular wall. Stimulation of eryptosis thus impairs microcirculation and leads to anemia as...

journal_title：International journal of cancer

authors： Lang E,Bissinger R,Qadri SM,Lang F

更新日期：2017-10-15 00:00:00

abstract：:A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...

journal_title：International journal of cancer

authors： Paci E,Ciatto S,Buiatti E,Cecchini S,Palli D,Rosselli del Turco M

更新日期：1990-08-15 00:00:00

abstract：:Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...

journal_title：International journal of cancer

authors： Tian Z,van Velkinburgh JC,Wu Y,Ni B

更新日期：2016-01-01 00:00:00

abstract：:Arrest and lodgement of circulating tumor cells in the microvasculature is a prerequisite for metastasis formation. Aggregation of activated platelets and subsequent release of bioactive substances seem to influence the lodgement process. Since thrombocytopenia has been shown to reduce lodgement and since 5-HT is one ...

journal_title：International journal of cancer

authors： Skolnik G,Bagge U,Dahlström A,Ahlman H

更新日期：1984-04-15 00:00:00

abstract：:Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...

journal_title：International journal of cancer

authors： Toh Y,Ohga T,Endo K,Adachi E,Kusumoto H,Haraguchi M,Okamura T,Nicolson GL

更新日期：2004-06-20 00:00:00

abstract：:The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...

journal_title：International journal of cancer

authors： Holmila R,Cyr D,Luce D,Heikkilä P,Dictor M,Steiniche T,Stjernvall T,Bornholdt J,Wallin H,Wolff H,Husgafvel-Pursiainen K

更新日期：2008-05-01 00:00:00

abstract：:Antitumor immunity in chronic lymphocytic leukemia (CLL) is hampered by highly dysfunctional T-cells. Although certain T-cell subsets have been reported to be of prognostic significance in this disease, their interplay is complex and it remains incompletely understood which of these subsets significantly drive CLL pro...

journal_title：International journal of cancer

authors： Rissiek A,Schulze C,Bacher U,Schieferdecker A,Thiele B,Jacholkowski A,Flammiger A,Horn C,Haag F,Tiegs G,Zirlik K,Trepel M,Tolosa E,Binder M

更新日期：2014-11-15 00:00:00