Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity.

abstract：:We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...

journal_title：International journal of cancer

authors： Andriani F,Garfield J,Fusenig NE,Garlick JA

更新日期：2004-01-20 00:00:00

abstract：:Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgen-independent prostate cancer. Recently, increased expression of Id-1, a basic helix-loop-helix protein, is reported in several types of advanced cancer. It is suggested that high expression of Id-1 may prov...

journal_title：International journal of cancer

authors： Zhang X,Ling MT,Wang X,Wong YC

更新日期：2006-04-15 00:00:00

abstract：:It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies a...

journal_title：International journal of cancer

authors： González CA,Pera G,Agudo A,Bueno-de-Mesquita HB,Ceroti M,Boeing H,Schulz M,Del Giudice G,Plebani M,Carneiro F,Berrino F,Sacerdote C,Tumino R,Panico S,Berglund G,Simán H,Hallmans G,Stenling R,Martinez C,Dorronsoro M

更新日期：2006-05-15 00:00:00

abstract：:Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...

journal_title：International journal of cancer

authors： Tomimaru Y,Eguchi H,Wada H,Kobayashi S,Marubashi S,Tanemura M,Umeshita K,Kim T,Wakasa K,Doki Y,Mori M,Nagano H

更新日期：2012-01-15 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL....

journal_title：International journal of cancer

authors： Toulza F,Nosaka K,Takiguchi M,Pagliuca T,Mitsuya H,Tanaka Y,Taylor GP,Bangham CR

更新日期：2009-11-15 00:00:00

abstract：:When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...

journal_title：International journal of cancer

authors： Lai PK,Alpers MP,MacKay-Scollay EM

更新日期：1977-07-15 00:00:00

abstract：:Cancer survival among people with AIDS (PWA) has been described in developed countries, but there is lack of data from developing countries. The aim of this study was to evaluate survival after cancer diagnosis in PWA and compare it with people without AIDS (non-PWA) in São Paulo, Brazil. A probabilistic record linkag...

journal_title：International journal of cancer

authors： Tanaka LF,Latorre MDRDO,Gutierrez EB,Curado MP,Dal Maso L,Herbinger KH,Froeschl G,Heumann C

更新日期：2018-02-01 00:00:00

abstract：:The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...

journal_title：International journal of cancer

authors： Luckenbach GA,Layton D

更新日期：1981-06-15 00:00:00

abstract：:There are few published estimates of the risk of developing breast or ovarian cancer in women with a strong family history of ovarian cancer. As these women commonly present to family cancer clinics, accurate cancer risk estimates are needed. We have estimated these risks in women from families with 2 or more confirme...

journal_title：International journal of cancer

authors： Sutcliffe S,Pharoah PD,Easton DF,Ponder BA

更新日期：2000-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...

journal_title：International journal of cancer

authors： Miao J,Chen GG,Chun SY,Yun JP,Chak EC,Ho RL,Lai PB

更新日期：2006-10-15 00:00:00

abstract：:We recently reported the identification of a human SART3 gene that encodes a tumor-rejection antigen recognized by cytotoxic T lymphocytes (CTLs). The squamous-cell carcinoma antigen recognized by T cells-3 (SART3) is an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including nor...

journal_title：International journal of cancer

authors： Harada K,Yamada A,Yang D,Itoh K,Shichijo S

更新日期：2001-09-01 00:00:00

abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

journal_title：International journal of cancer

authors： To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

更新日期：2005-07-01 00:00:00

abstract：:Cyclic AMP (cAMP) analogues that selectively bind to either one of the two binding sites of cAMP-dependent protein kinase demonstrate a potent inhibition of the growth stimulated by estrogen in MCF-7 human breast-cancer cells in culture. The site-selective analogues, which are more potent activators of protein kinase ...

journal_title：International journal of cancer

authors： Katsaros D,Ally S,Cho-Chung YS

更新日期：1988-06-15 00:00:00

abstract：:MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...

journal_title：International journal of cancer

authors： Cormier JN,Hijazi YM,Abati A,Fetsch P,Bettinotti M,Steinberg SM,Rosenberg SA,Marincola FM

更新日期：1998-02-09 00:00:00

abstract：:Seventy to 40% of K-RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti-EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF-1 system, altered activation colorectal cancer cells may escape anti-EGFR mediated cell death. The inter...

journal_title：International journal of cancer

authors： Scartozzi M,Mandolesi A,Giampieri R,Pierantoni C,Loupakis F,Zaniboni A,Galizia E,Giustini L,Silva RR,Bisonni R,Berardi R,Biagetti S,Menzo S,Falcone A,Bearzi I,Cascinu S

更新日期：2010-10-15 00:00:00

abstract：:Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...

journal_title：International journal of cancer

authors： Gudnason V,Ingvarsson S,Jonasdottir A,Andresdottir V,Egilsson V

更新日期：1984-07-15 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Immunohistochemical studies have shown that this overexpression is linked to higher aggressiveness of colorectal carcinoma and to enhanced metastatic potential of melanoma cells. However, the antibodies so far developed against Nup88 have the draw...

journal_title：International journal of cancer

authors： Agudo D,Gómez-Esquer F,Martínez-Arribas F,Núñez-Villar MJ,Pollán M,Schneider J

更新日期：2004-05-01 00:00:00

abstract：:It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...

journal_title：International journal of cancer

authors： Tsuda H,Takarabe T,Okada S,Uchida H,Kasamatsu T,Yamada T,Tsunematsu R,Ohmi K,Hirohashi S

更新日期：2002-04-10 00:00:00

abstract：:We assessed prospectively whether residual cervical intraepithelial neoplasia (CIN) after treatment for high-grade CIN can be predicted by genotype-specific high-risk HPV (HR-HPV) detection in follow-up cervical scrapes. A broad spectrum, highly sensitive SPF(10)-LiPA-PCR HPV detection technique was used on cervical s...

journal_title：International journal of cancer

authors： Bekkers RL,Melchers WJ,Bakkers JM,Hanselaar AG,Quint WG,Boonstra H,Massuger LF

更新日期：2002-11-10 00:00:00

abstract：:Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...

journal_title：International journal of cancer

authors： Süsal C,Maier H,Lorenz K,Opelz G

更新日期：1994-04-01 00:00:00

abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

journal_title：International journal of cancer

authors： Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

更新日期：2008-04-15 00:00:00

abstract：:Therapies targeted to human epidermal growth factor receptor 2 (HER2) have proven effective against tumors positive for HER2 amplification, but there is an unmet clinical need for the treatment of tumors that express HER2 protein in the absence of HER2 amplification. [fam-] trastuzumab deruxtecan (DS-8201a) is a novel...

journal_title：International journal of cancer

authors： Takegawa N,Tsurutani J,Kawakami H,Yonesaka K,Kato R,Haratani K,Hayashi H,Takeda M,Nonagase Y,Maenishi O,Nakagawa K

更新日期：2019-12-15 00:00:00

abstract：:Nitric oxide (NO) generated by either endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) may be involved in prostate tumorigenesis through the inhibition of reactive oxygen species (ROS)-induced apoptosis. Multicellular DU-145 prostate tumor spheroids endogenously generated NO that para...

journal_title：International journal of cancer

authors： Wartenberg M,Schallenberg M,Hescheler J,Sauer H

更新日期：2003-04-10 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:The causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case-control dataset. The subjects were d...

journal_title：International journal of cancer

authors： Von Behren J,Spector LG,Mueller BA,Carozza SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin C,Puumala SE,Ross JA,Reynolds P

更新日期：2011-06-01 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:A series of 42 patients with malignant melanoma treated with BCG adjuvant immunotherapy were studied for sequential changes in cellular immune reactivity to non-specific mitogens. Lymphocyte preparations were made monthly and stored in a viable condition in liquid nitrogen. After 6 months of treatment, all lymphocyte ...

journal_title：International journal of cancer

authors： Golub SH,Forsythe AB,Morton DL

更新日期：1977-01-01 00:00:00

abstract：:Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis o...

journal_title：International journal of cancer

authors： Xia B,He Q,Pan Y,Gao F,Liu A,Tang Y,Chong C,Teoh AYB,Li F,He Y,Zhang C,Yuan J

更新日期：2020-12-15 00:00:00

abstract：:To evaluate the relation between the degree of lymph node metastasis and the growth potential of tumour cells and the local immune function in gastric cancer, we analyzed data on 444 patients with advanced serosally invasive gastric cancer who underwent curative gastrectomy. Tumour growth potential was evaluated based...

journal_title：International journal of cancer

authors： Maehara Y,Tomisaki S,Oda S,Kakeji Y,Tsujitani S,Ichiyoshi Y,Akazawa K,Sugimachi K

更新日期：1997-04-22 00:00:00