Abstract：
:Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline in incidence was more pronounced in younger age strata, 35-54 years, while in females it reached a maximum at ages 70-74 years. In a multivariate analysis the age-cohort model adequately represented the data and there was no reason to separate the effects of the full age-period-cohort model. Compared with the cohort born in 1876-1884, the relative risk of developing stomach cancer was 0.46 (95% CI:0.44-0.48) in males and 0.39 (95% CI:0.37-0.42) in females born in 1906-1914. This supports the view that the declining incidence is due to a change in the exposure of the population to aetiological factors of stomach cancer and not to refinement of the diagnosis and classification of abdominal tumours. The results also imply that exposure to aetiological factors early in life together with a long induction period is of importance in the development of stomach cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Hansson LE,Bergström R,Sparén P,Adami HOdoi
10.1002/ijc.2910470405subject
Has Abstractpub_date
1991-02-20 00:00:00pages
499-503issue
4eissn
0020-7136issn
1097-0215journal_volume
47pub_type
杂志文章abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250402
更新日期：1980-04-15 00:00:00
abstract：:Cultured cells derived from pregnancy-dependent mouse mammary tumors (plaques) when transplanted into the gland-free mammary fat pad display a heterogeneous developmental potential. They not only gave rise to plaques but also produced normal mammary gland, hyperplastic alvoelar nodules (HAN), and autonomous mammary tu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910230520
更新日期：1979-05-15 00:00:00
abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910350220
更新日期：1985-02-15 00:00:00
abstract：:Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980911)77:6<833::aid-ijc
更新日期：1998-09-11 00:00:00
abstract：:Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation. More than half o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21339
更新日期：2006-01-15 00:00:00
abstract：:Resveratrol, which may occur in wine, was suggested to act as a chemopreventive agent against the carcinogenic effects of ethanol. The assumption was based on data from experimental animals, which have shown that resveratrol above certain thresholds may reduce the incidence of tumours in several of the alcohol-related...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28336
更新日期：2014-01-01 00:00:00
abstract：:Mucinous colorectal cancer often presents at an advanced stage. We have previously observed that mucin production by human colon-cancer cells correlates with their ability to colonize the liver in experimental animal models. The present study was undertaken in order to further elucidate the mechanisms by which product...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520113
更新日期：1992-08-19 00:00:00
abstract：:The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10525
更新日期：2002-08-10 00:00:00
abstract：:Tyrosine kinase inhibitors are effective treatments for cancers. Knowing the specific kinase mutants that drive the underlying cancers predict therapeutic response to these inhibitors. Thus, the current protocol for personalized cancer therapy involves genotyping tumors in search of various driver mutations and subseq...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31045
更新日期：2018-01-01 00:00:00
abstract：:Urinary bladder cancer is a heterogeneous disease with tumors ranging from papillary noninvasive (stage Ta) to solid muscle infiltrating tumors (stage T2+). The risk of progression and death for the most frequent diagnosed type, Ta, is low, but the high incidence of recurrences has a significant effect on the patients...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24954
更新日期：2010-03-15 00:00:00
abstract：:This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21404
更新日期：2006-05-15 00:00:00
abstract：:Dietary factors in the aetiology of stomach cancer were investigated using data from a case-control study conducted in Northern Italy on 206 histologically confirmed carcinomas and 474 control subjects in hospital for acute, non-digestive conditions, unrelated to any of the potential risk factors for gastric cancer. D...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400409
更新日期：1987-10-15 00:00:00
abstract：:We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33400
更新日期：2020-11-16 00:00:00
abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910290106
更新日期：1982-01-15 00:00:00
abstract：:Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26120
更新日期：2011-10-01 00:00:00
abstract：:CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28727
更新日期：2014-08-15 00:00:00
abstract：:Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11413
更新日期：2003-11-10 00:00:00
abstract：:Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22687
更新日期：2007-07-01 00:00:00
abstract：:Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910270108
更新日期：1981-01-15 00:00:00
abstract：:Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22098
更新日期：2006-12-01 00:00:00
abstract：:The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22607
更新日期：2007-07-01 00:00:00
abstract：:We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910570519
更新日期：1994-06-01 00:00:00
abstract：:Double-label immunofluorescence was used to monitor basement-membrane composition and integrity in 22 human colon polyps, 36 adenocarcinomas and 2 metastases. Cryostat sections were stained with polyclonal anti-laminin anti-serum combined with monoclonal antibodies (MAbs) to all major basement-membrane components (lam...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910500412
更新日期：1992-02-20 00:00:00
abstract：:The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20000720)89:4<356::aid-ijc7>3.0.
更新日期：2000-07-20 00:00:00
abstract：:The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphoru...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33246
更新日期：2021-02-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents the eighth frequent solid tumor and fourth leading cause of cancer death. Because current treatments against PDAC are still unsatisfactory, new anticancer strategies are required, including oncolytic viruses. Among these, autonomous parvoviruses (PV), like MVMp (minut...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24992
更新日期：2010-06-15 00:00:00
abstract：:The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20009
更新日期：2004-05-01 00:00:00
abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25367
更新日期：2011-02-01 00:00:00
abstract：:TP53 accumulation in human primary breast carcinomas was studied by a quantitative luminometric immunoassay (LIA), and TP53 gene alterations, exons 5-8, were examined by single-strand conformation polymorphism (SSCP) analysis. In 48 of 142 breast tumor samples, a TP53 gene alteration was identified. In tumor samples w...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960422)69:2<125::AID-IJC
更新日期：1996-04-22 00:00:00
abstract：:Using a microarray technique, we found decorin to be underexpressed, but osteopontin (OPN) to be overexpressed, in esophageal squamous cell carcinoma (ESCC). This study aims to examine whether plasma decorin and OPN plus personal substances use (tobacco, alcohol and areca) can serve as suitable clinical markers to pre...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25239
更新日期：2010-11-01 00:00:00
