Abstract:
:Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinogen treatment varies directly with lymphotoxin concentration. The frequency of transformation does not change following re-feeding with lymphotoxin-free medium and incubation for 6 additional days. Furthermore, transformation by ultraviolet is prevented when cells are pulsed with lymphotoxin for as few as 6 hours after irradiation. Thus, lymphotoxin has the potential to irreversibly inhibit the first recognizable morphologic step of carcinogenesis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Evans CH,DiPaolo JAdoi
10.1002/ijc.2910270108subject
Has Abstractpub_date
1981-01-15 00:00:00pages
45-9issue
1eissn
0020-7136issn
1097-0215journal_volume
27pub_type
杂志文章abstract::The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22653
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abstract::The purpose of our study was to investigate a novel therapeutic approach for rhabdomyosarcoma (RMS) in an animal model. The pursuit of new therapeutic modalities for RMS is critically important since this type of tumor is the most common soft tissue sarcoma in children and because patients with metastatic disease may ...
journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::Although the incidence of, and deaths due to, malignant melanoma are rising at a rapid rate, few experimental models mimic the highly metastatic properties associated with the pathogenesis of the human disease, making study of the disease difficult. Thus, new human models are required to understand melanoma biology, e...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910470211
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
abstract::Serum tyrosinase activity has been measured by adapting the [3]tyrosine assay for tyrosinase and significant elevations of serum tyrosinase activity were found in patients with malignant melanoma. In contrast to findings in a study which utilized [14C]tyrosine, augmented levels of tyrosinase activity were not observed...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910200507
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abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title:International journal of cancer
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doi:10.1002/ijc.1319
更新日期:2001-07-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.11279
更新日期:2003-09-10 00:00:00
abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340219
更新日期:1984-08-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.21339
更新日期:2006-01-15 00:00:00
abstract::Loss of heterozygosity on chromosome arm 16q frequently occurs in human breast carcinomas regardless of the histological grade or type. To reveal whether the status of chromosome 16 corresponds to the histology of breast carcinomas, we examined the signal number of 16cen, 16q breakpoints and 1;16 fusions in the interp...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1999-08-20 00:00:00
abstract::We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980610)76:6<784::aid-ijc
更新日期:1998-06-10 00:00:00
abstract::The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23777
更新日期:2008-11-01 00:00:00
abstract::With metastatic disease at diagnosis for 70% of patients, ovarian cancer represents the most lethal gynecological malignancy. Ovarian carcinomas are aggressive malignancies that can evade immune surveillance and frequently develop into metastases. The tumor microenvironment is decisive for preventing immune attack but...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24881
更新日期:2010-05-01 00:00:00
abstract::Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.23037
更新日期:2007-12-15 00:00:00
abstract::Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24472
更新日期:2009-10-01 00:00:00
abstract::Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990505)81:3<443::aid-ijc
更新日期:1999-05-05 00:00:00
abstract::The Ontario Cancer Registry (OCR) and the Surveillance, Epidemiology and End Results (SEER) databases were used to describe temporal trends in the incidence and survival of squamous cancers of the upper aerodigestive tract (UADT) in Ontario and the US between 1984 and 2001. Between the 1984-86 and 1999-01 periods, the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24533
更新日期:2009-11-01 00:00:00
abstract::A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<895::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::Six permanent human tumor cell lines (OV-MZ-1 to 6) were established from 6 patients with serous adenocarcinomas of the ovary. These cell lines were derived from both solid tumors and ascites, from pre-treated and untreated patients, and are available over a range of in vitro passage numbers. The tumor cells grow as m...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1992-08-19 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::Laser scanning confocal microscopy has been used to follow the uptake and efflux of the 2-fluoroglycoside of doxorubicin, ME2303, in live cultures of the human ovarian cancer cell line A2780 and its doxorubicin-resistant variant A2780AD. Our methods combine confocal laser scanning microscopy and image analysis to exam...
journal_title:International journal of cancer
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abstract::Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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更新日期:2009-03-15 00:00:00
abstract::The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310116
更新日期:1983-01-15 00:00:00
abstract::Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320416
更新日期:1983-10-15 00:00:00
abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...
journal_title:International journal of cancer
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更新日期:2007-09-15 00:00:00
abstract::The effects on cell survival in tissue culture of Adriamycin, of various Adriamycin derivatives and of the parent compound, daunomycin, have been studied. Adriamycin and three of its C-14 derivatives show similar toxicities towards cells chronically exposed in culture. Acute (30 min) exposures are significantly less t...
journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::Although several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC), the data published so far are not concordant. A reason for these discrepancies may be the fact that most studies used the nontumorous tissue surrounding the HCC lesion as a control, which is almost invariably affe...
journal_title:International journal of cancer
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更新日期:2013-08-15 00:00:00
abstract::Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-scatter factor (HGF-SF) in this phenomenon. Markedly increased serum levels...
journal_title:International journal of cancer
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更新日期:2000-01-15 00:00:00
abstract::Cancer stem cells (CSCs) are initiating cells in colorectal cancer (CRC). Colorectal tumours undergo epithelial to mesenchymal transition (EMT)-like processes at the invasive front, enabling invasion and metastasis, and recent studies have linked this process to the acquisition of stem cell-like properties. It is of f...
journal_title:International journal of cancer
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更新日期:2012-01-15 00:00:00
abstract::Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...
journal_title:International journal of cancer
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更新日期:2007-07-01 00:00:00