Karyotype evolution in a transformed rat cerebral endothelial cell line.

abstract：:Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...

journal_title：International journal of cancer

authors： Jiang S,Li T,Yang Z,Hu W,Yang Y

更新日期：2018-10-01 00:00:00

abstract：:Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...

journal_title：International journal of cancer

authors： Nielsen K,Måsbäck A,Olsson H,Ingvar C

更新日期：2012-08-01 00:00:00

abstract：:The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

journal_title：International journal of cancer

authors： Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

更新日期：2000-06-15 00:00:00

abstract：:Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

journal_title：International journal of cancer

authors： Nagy A,Zoubakov D,Stupar Z,Kovacs G

更新日期：2004-04-10 00:00:00

abstract：:Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

journal_title：International journal of cancer

authors： Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

更新日期：2001-06-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...

journal_title：International journal of cancer

authors： Franke FC,Slusarenko BO,Engleitner T,Johannes W,Laschinger M,Rad R,Nitsche U,Janssen KP

更新日期：2020-09-15 00:00:00

abstract：:The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

journal_title：International journal of cancer

authors： Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

更新日期：1992-05-28 00:00:00

abstract：:A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden...

journal_title：International journal of cancer

authors： Landgren O,Linet MS,McMaster ML,Gridley G,Hemminki K,Goldin LR

更新日期：2006-06-15 00:00:00

abstract：:Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet a...

journal_title：International journal of cancer

authors： Brandt J,Borgquist S,Almgren P,Försti A,Huss L,Melander O,Manjer J

更新日期：2018-04-01 00:00:00

abstract：:Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...

journal_title：International journal of cancer

authors： Inoue M,Okayama A,Fujita M,Enomoto T,Sakata M,Tanizawa O,Ueshima H

更新日期：1994-07-01 00:00:00

abstract：:The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DN...

journal_title：International journal of cancer

authors： Ogino S,Kawasaki T,Nosho K,Ohnishi M,Suemoto Y,Kirkner GJ,Fuchs CS

更新日期：2008-06-15 00:00:00

abstract：:Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...

journal_title：International journal of cancer

authors： Yhim HY,Kim JS,Kang HJ,Kim SJ,Kim WS,Choi CW,Eom HS,Kim JA,Lee JH,Won JH,Shim H,Huh J,Lee DH,Suh C,Kwak JY

更新日期：2012-07-01 00:00:00

abstract：:The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...

journal_title：International journal of cancer

authors： Rieker RJ,Hoegel J,Morresi-Hauf A,Hofmann WJ,Blaeker H,Penzel R,Otto HF

更新日期：2002-04-20 00:00:00

abstract：:Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

journal_title：International journal of cancer

authors： de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

更新日期：2009-10-01 00:00:00

abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...

journal_title：International journal of cancer

authors： Mantovani A,Peri G,Polentarutti N,Bolis G,Mangioni C,Spreafico F

更新日期：1979-02-01 00:00:00

abstract：:Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

journal_title：International journal of cancer

authors： Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

更新日期：2012-01-15 00:00:00

abstract：:Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...

journal_title：International journal of cancer

authors： Béraud C,Dormoy V,Danilin S,Lindner V,Béthry A,Hochane M,Coquard C,Barthelmebs M,Jacqmin D,Lang H,Massfelder T

更新日期：2015-10-01 00:00:00

abstract：:While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the...

journal_title：International journal of cancer

authors： Heller S,Scheibenpflug L,Westermark B,Nistér M

更新日期：2000-01-15 00:00:00

abstract：:One hundred and eighty-five patients with untreated Hodgkin's disease (HD) comprising 86% of all new cases diagnosed in Denmark over a 2-year period, were individually matched with healthy controls of the same age, sex, and social class. In comparison to controls, HD patients showed significantly elevated mean antibod...

journal_title：International journal of cancer

authors： Hesse J,Levine PH,Ebbesen P,Connelly RR,Mordhorst CH

更新日期：1977-01-01 00:00:00

abstract：:Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...

journal_title：International journal of cancer

authors： Staib L,Birebent B,Somasundaram R,Purev E,Braumüller H,Leeser C,Küttner N,Li W,Zhu D,Diao J,Wunner W,Speicher D,Beger HG,Song H,Herlyn D

更新日期：2001-04-01 00:00:00

abstract：:A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...

journal_title：International journal of cancer

authors： Díez O,Cortés J,Domènech M,Brunet J,Del Río E,Pericay C,Sanz J,Alonso C,Baiget M

更新日期：1999-11-12 00:00:00

abstract：:A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...

journal_title：International journal of cancer

authors： Pukkala E,Kyyrönen P,Sankila R,Holli K

更新日期：2002-07-20 00:00:00

abstract：:This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-...

journal_title：International journal of cancer

authors： Woo YL,van den Hende M,Sterling JC,Coleman N,Crawford RA,Kwappenberg KM,Stanley MA,van der Burg SH

更新日期：2010-01-01 00:00:00

abstract：:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...

journal_title：International journal of cancer

authors： Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A

更新日期：1987-01-15 00:00:00

abstract：:Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...

journal_title：International journal of cancer

authors： Bijnsdorp IV,Peters GJ,Temmink OH,Fukushima M,Kruyt FA

更新日期：2010-05-15 00:00:00

abstract：:The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...

journal_title：International journal of cancer

authors： Nguyen QM,Nguyen HC,Parkin DM

更新日期：1998-05-18 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:We report on pigmentary characteristics, sun sensitivity and some other possible risk factors for non-Hodgkin lymphoma (NHL) in people 20-74 years of age. A statewide case-control study was conducted in New South Wales, Australia, with population-based sampling of cases (n = 704) and controls (n = 694). Risk of NHL wa...

journal_title：International journal of cancer

authors： Hughes AM,Armstrong BK,Vajdic CM,Turner J,Grulich A,Fritschi L,Milliken S,Kaldor J,Benke G,Kricker A

更新日期：2004-06-20 00:00:00

abstract：:Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...

journal_title：International journal of cancer

authors： Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB

更新日期：1986-10-15 00:00:00

abstract：:Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...

journal_title：International journal of cancer

authors： Jonsson BA,Bergh A,Stattin P,Emmanuelsson M,Grönberg H

更新日期：2002-04-20 00:00:00