Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease.


:Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identified lytic EBV proteins that activate IL-6 production and compared viral and cellular differences between early versus late passage LCLs (LPL). IL-6 was required for efficient growth of EPL in SCID mice. The EBV immediate-early (IE) proteins, BRLF1 and BZLF1, each induced IL-6 secretion when transfected into 293 and BJAB cells. Interestingly, the combination of BZLF1 and the latent EBV protein, LMP-1, induced much more IL-6 expression in both 293 and BJAB cells than either protein alone. Both BZLF1 and BRLF1 also enhanced IL-10 production in 293 cells. In comparison to the EPL, LPL had much reduced expression of early lytic viral proteins and cellular IL-6. In contrast, expression of cellular IL-10 was similar in EPL versus LPL, while VEGF secretion was increased in late-passage LCLs. These results suggest that both BRLF1 and BZLF1 contribute to IL-6 secretion in lytically infected cells and that lytically infected cells may promote early lymphoproliferative disease in patients through enhanced IL-6 production.


Int J Cancer


Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC




Has Abstract


2007-09-15 00:00:00












  • Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS.

    abstract::Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sect...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nawar E,Mbulaiteye SM,Gallant JE,Wohl DA,Ardini M,Hendershot T,Goedert JJ,Rabkin CS,AIDS Cancer Cohort (ACC) Study Collaborators.

    更新日期:2005-06-10 00:00:00

  • Clonal heterogeneity in sporadic melanomas as revealed by loss-of-heterozygosity analysis.

    abstract::The major obstacle preventing effective treatment of melanoma is the biological heterogeneity of tumor cells. This study was performed to determine clonal genetic heterogeneity within primary melanoma and the evolution of these heterogeneous sub-clones during disease progression. DNA samples were obtained from 44 morp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takata M,Morita R,Takehara K

    更新日期:2000-02-15 00:00:00

  • Inhibition of in vitro lymphoproliferative responses to tumor-associated antigens by suppressor cells from rats bearing progressively growing Gross leukemia virus-induced tumors.

    abstract::W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Glaser M,Kirchner H,Herberman RB

    更新日期:1975-09-15 00:00:00

  • Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study.

    abstract::In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sobue T,Yamamoto S,Hara M,Sasazuki S,Sasaki S,Tsugane S,JPHC Study Group. Japanese Public Health Center.

    更新日期:2002-05-10 00:00:00

  • Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant.

    abstract::In experimental tumor immunotherapy, incomplete Freund's adjuvant (IFA) has been considered as the "gold standard" for T-cell vaccination in mice and humans in spite of its considerable adverse effects. Recently, we succeeded in eliciting strong CTL responses in mice after vaccination with biodegradable poly(D,L-lacti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mueller M,Schlosser E,Gander B,Groettrup M

    更新日期:2011-07-15 00:00:00

  • 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.

    abstract::The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lin HL,Yang MH,Wu CW,Chen PM,Yang YP,Chu YR,Kao CL,Ku HH,Lo JF,Liou JP,Chi CW,Chiou SH

    更新日期:2007-12-01 00:00:00

  • Inherited variation at MC1R and ASIP and association with melanoma-specific survival.

    abstract::Melanocortin-1 receptor (MC1R) is a marker of melanoma risk in populations of European ancestry. However, MC1R effects on survival are much less studied. We investigated associations between variation at MC1R and survival in an international, population-based series of single primary melanoma patients enrolled into th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Taylor NJ,Reiner AS,Begg CB,Cust AE,Busam KJ,Anton-Culver H,Dwyer T,From L,Gallagher RP,Gruber SB,Rosso S,White KA,Zanetti R,Orlow I,Thomas NE,Rebbeck TR,Berwick M,Kanetsky PA,GEM Study Group.

    更新日期:2015-06-01 00:00:00

  • Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

    更新日期:1999-10-29 00:00:00

  • Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions.

    abstract::Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saeed K,Östling P,Björkman M,Mirtti T,Alanen K,Vesterinen T,Sankila A,Lundin J,Lundin M,Rannikko A,Nordling S,Mpindi JP,Kohonen P,Iljin K,Kallioniemi O,Rantala JK

    更新日期:2015-06-01 00:00:00

  • Relation of smoking to breast cancer by estrogen receptor status.

    abstract::It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Morabia A,Bernstein M,Ruiz J,Héritier S,Diebold Berger S,Borisch B

    更新日期:1998-01-30 00:00:00

  • Genetic variation of XPA gene and risk of cancer: a systematic review and pooled analysis.

    abstract::XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA -4G>A polymorphism was identified in the 5' noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Ding D,Zhang Y,Yu H,Guo Y,Jiang L,He X,Ma W,Zheng W

    更新日期:2012-07-15 00:00:00

  • Karyotypic characterization of bronchial large cell carcinomas.

    abstract::Cytogenetic analysis of short-term cultures from 26 primary bronchial large cell carcinomas and 1 metastasis from a primary large cell carcinoma revealed clonal chromosome abnormalities in 20 tumors and a normal karyotype in 6. No outgrowth was obtained in 1 case. Simple aberrations were present in 3 tumors; in 1, the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Johansson M,Dietrich C,Mandahl N,Hambraeus G,Johansson L,Clausen PP,Mitelman F,Heim S

    更新日期:1994-05-15 00:00:00

  • Dosimetric analysis of urinary morbidity following prostate brachytherapy (125I vs. 103Pd) combined with external beam radiation therapy.

    abstract::The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen CT,Waterman FM,Valicenti RK,Gomella LG,Strup SE,Dicker AP

    更新日期:2001-01-01 00:00:00

  • Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer.

    abstract::The development of reliable gene expression profiling technology is having an increasing impact on our understanding of lung cancer biology. Our study aimed to determine any correlation between the phenotypic heterogeneity and genetic diversity of lung cancer. Microarray analysis was performed on a set of 46 tumor sam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sanchez-Palencia A,Gomez-Morales M,Gomez-Capilla JA,Pedraza V,Boyero L,Rosell R,Fárez-Vidal ME

    更新日期:2011-07-15 00:00:00

  • Heterogeneity of HLA and EBER expression in Epstein-Barr virus-associated nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yao Y,Minter HA,Chen X,Reynolds GM,Bromley M,Arrand JR

    更新日期:2000-12-15 00:00:00

  • Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes.

    abstract::The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Manzotti M,Dell'Orto P,Maisonneuve P,Zurrida S,Mazzarol G,Viale G

    更新日期:2001-09-20 00:00:00

  • Tumor lymphangiogenesis and metastatic spread-new players begin to emerge.

    abstract::The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Achen MG,Stacker SA

    更新日期:2006-10-15 00:00:00

  • Human monoclonal antibody GNX-8 directed to extended type 1 chain: Specific binding to human colorectal cancer.

    abstract::We observed previously that two carbohydrate epitopes, extended type 1 chain Le(a)-Le(a) and Le(b)-Le(a), are expressed strongly in human gastric or colorectal cancer and cell lines derived therefrom, but their expression in human normal colorectal cells is highly limited. A monoclonal antibody, termed GNX-8, was esta...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang MC,Hsu FL,Handa K,Hakomori S,Lee MH,Liu LY,Chang SY,Ting J,Wen JY,Ishida I,Chang TH

    更新日期:2009-12-21 00:00:00

  • Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.

    abstract::Two factors potentially determining the consistent overexpression of sialyl-Le(x) antigen in colon carcinoma and metastases were investigated: (i) the expression of the mucins MUC1 and MUC2, known to carry sialyl-Le(x), by Northern blotting; (ii) the extent of sialic acid O-acetylation, by Western blotting and HPLC. R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mann B,Klussmann E,Vandamme-Feldhaus V,Iwersen M,Hanski ML,Riecken EO,Buhr HJ,Schauer R,Kim YS,Hanski C

    更新日期:1997-07-17 00:00:00

  • Stromal cells from human benign prostate hyperplasia produce a growth-inhibitory factor for LNCaP prostate cancer cells, identified as interleukin-6.

    abstract::To understand specific interactions between stromal cells and epithelial cells in benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma, we developed stromal-cell cultures from normal human prostate (PNX) and BPH (BH101), composed of fibroblasts and myofibroblasts. Their role in epithelial-cell growth was st...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Degeorges A,Tatoud R,Fauvel-Lafeve F,Podgorniak MP,Millot G,de Cremoux P,Calvo F

    更新日期:1996-10-09 00:00:00

  • A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line.

    abstract::Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of patients respond poorly to PTX or relapse after its use, a greater und...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasham A,Mehta SY,Fitzgerald SJ,Woolley AG,Hearn JI,Hurley DG,Ruza I,Algie M,Shelling AN,Braithwaite AW,Print CG

    更新日期:2016-09-01 00:00:00

  • Selective inhibition of PED protein expression sensitizes B-cell chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis.

    abstract::B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Garofalo M,Romano G,Quintavalle C,Romano MF,Chiurazzi F,Zanca C,Condorelli G

    更新日期:2007-03-15 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期:2020-05-15 00:00:00

  • Changing role of 3 screening modalities in the European randomized study of screening for prostate cancer (Rotterdam).

    abstract::A randomized screening trial was started in Europe to show the effect of early detection and treatment of prostate cancer on mortality (European Study on Screening of Prostate Cancer). In one centre (Rotterdam), the screening protocol initially consisted of 3 screening tests for all men: prostate-specific antigen (PSA...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beemsterboer PM,Kranse R,de Koning HJ,Habbema JD,Schröder FH

    更新日期:1999-08-20 00:00:00

  • Topoisomerase-I inhibitors for human malignant glioma: differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta-lapachone.

    abstract::Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weller M,Winter S,Schmidt C,Esser P,Fontana A,Dichgans J,Groscurth P

    更新日期:1997-11-27 00:00:00

  • Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

    abstract::Infection of tumors with an adenoviral vector expressing a chimeric gene composed of the CArG elements of the Egr-1 promoter and a cDNA encoding TNF-alpha (Ad.Egr-TNF) has previously been shown to result in the production of high intratumoral levels of TNF-alpha and thereby tumor regression. The antitumor effects of T...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mauceri HJ,Seetharam S,Beckett MA,Lee JY,Gupta VK,Gately S,Stack MS,Brown CK,Swedberg K,Kufe DW,Weichselbaum RR

    更新日期:2002-02-01 00:00:00

  • Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.

    abstract::TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kocher T,Zheng M,Bolli M,Simon R,Forster T,Schultz-Thater E,Remmel E,Noppen C,Schmid U,Ackermann D,Mihatsch MJ,Gasser T,Heberer M,Sauter G,Spagnoli GC

    更新日期:2002-08-20 00:00:00

  • Increased DNA methyltransferase expression in rhabdomyosarcomas.

    abstract::In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

    更新日期:1999-09-24 00:00:00

  • Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

    abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

    更新日期:2010-08-01 00:00:00

  • Urine estrogens and breast cancer risk factors among post-menopausal women.

    abstract::Creatinine-adjusted levels of estrone, estradiol and estriol were determined in overnight urine specimens from 220 post-menopausal women, aged 54 to 66 years, from Boston (121 women) and Athens (99 women). The associations of individual and total estrogens with various characteristics of the women (age at menopause, y...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trichopoulos D,Brown J,MacMahon B

    更新日期:1987-12-15 00:00:00