Human papillomavirus--the most significant risk determinant of cervical intraepithelial neoplasia.


:Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesions or high-grade squamous intraepithelial lesions as defined by cytology and 1000 control women selected from an ongoing prospective cohort study in Copenhagen, Denmark. Furthermore, 131 women with equivocal smears (atypical squamous cells of undetermined significance) were examined as a separate borderline case group. At enrollment, all women had a personal interview and a gynecological examination including cervical swabs for HPV testing and a Pap smear. HPV testing was performed using a combination of general primer 5/6-mediated and type-specific polymerase-chain-reaction-based methods. Cervical HPV infection was by far the most significant risk factor for cervical squamous intraepithelial lesions. The relationship with HPV was observed for all grades, while strength of association was greater for more severe lesions. The importance of the previously identified epidemiological risk factors for cervical neoplasia was also demonstrated. However, most of the effect of these factors could be explained by taking HPV infection into account, except for schooling and smoking. Non-use of barrier contraceptives and smoking were the only significant risk factors in HPV-positive women. In HPV-negative women, a residual effect existed for different measures of sexual activity, and use of oral contraceptives and smoking constituted significant risk determinants Overall, 66% of cases could be attributed to HPV; however, if the results were restricted to histologically confirmed high-grade lesions, the proportion of cases that could be attributed to HPV infection increased to 80%.


Int J Cancer


Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ




Has Abstract


1996-03-01 00:00:00














  • Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1.

    abstract::Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN-C and MMPs are often co-localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulation. To investigate whether TN-C ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kalembeyi I,Inada H,Nishiura R,Imanaka-Yoshida K,Sakakura T,Yoshida T

    更新日期:2003-05-20 00:00:00

  • Genetic alterations in gastric cancer cell lines and their original tissues.

    abstract::To investigate the genetic changes that occur during establishment of gastric cancer cell lines, 4 gastric cancer cell lines and their original tumor tissues were examined for microsatellite instability (MSI), loss of heterozygosity (LOH), and p53 mutation. MSI status did not change during the establishment, though th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bae SI,Park JG,Kim YI,Kim WH

    更新日期:2000-08-15 00:00:00

  • Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.

    abstract::Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

    更新日期:2009-10-01 00:00:00

  • Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma.

    abstract::Histone H3 lysine 9 trimethylation (H3K9me3) is associated with transcriptional repression and regulated by histone lysine methyltransferases such as SUV39H1 and ESET. However, the functional roles of these enzymes in hepatocellular carcinoma (HCC) remain uncertain. In this study, we conducted loss-of-function assays ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chiba T,Saito T,Yuki K,Zen Y,Koide S,Kanogawa N,Motoyama T,Ogasawara S,Suzuki E,Ooka Y,Tawada A,Otsuka M,Miyazaki M,Iwama A,Yokosuka O

    更新日期:2015-01-15 00:00:00

  • Tonsillitis, tonsillectomy and Hodgkin's lymphoma.

    abstract::It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vestergaard H,Westergaard T,Wohlfahrt J,Hjalgrim H,Melbye M

    更新日期:2010-08-01 00:00:00

  • Repair of DNA damage induced by accelerated heavy ions--a mini review.

    abstract::Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Okayasu R

    更新日期:2012-03-01 00:00:00

  • Partial characterization of viral DNA from human genital warts (Condylomata acuminata).

    abstract::By centrifuging total cellular DNA derived from human genital warts (condylomata acuminata) in CsCl-ethidium bromide gradients, supercoiled DNA was isolated. The molecular weight of this DNA was determined by agarose gel electrophoresis and amounted to 5.1 X 10(4). This DNA isolated from an individual genital wart was...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gissmann L,zur Hausen H

    更新日期:1980-05-15 00:00:00

  • Genetic variation of XPA gene and risk of cancer: a systematic review and pooled analysis.

    abstract::XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA -4G>A polymorphism was identified in the 5' noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Ding D,Zhang Y,Yu H,Guo Y,Jiang L,He X,Ma W,Zheng W

    更新日期:2012-07-15 00:00:00

  • Changes in lung-cancer mortality trends in Spain.

    abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Franco J,Pérez-Hoyos S,Plaza P

    更新日期:2002-01-01 00:00:00

  • Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

    abstract::It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Davies M,Paterson IC,Ganapathy A,Prime SS

    更新日期:2006-12-15 00:00:00

  • Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma.

    abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fest S,Soldati R,Christiansen NM,Zenclussen ML,Kilz J,Berger E,Starke S,Lode HN,Engel C,Zenclussen AC,Christiansen H

    更新日期:2016-04-15 00:00:00

  • A novel copper complex of 3-benzoyl-alpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathway.

    abstract::Pancreatic cancer (PC) is characterized as one of the deadliest malignancies and its treatment is a great challenge to clinical oncologists. Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ahmed F,Adsule S,Ali AS,Banerjee S,Ali S,Kulkarni S,Padhye S,Sarkar FH

    更新日期:2007-02-15 00:00:00

  • A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines.

    abstract::We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thomson JA,Leonard JH,McGregor K,Sturm RA,Parsons PG

    更新日期:1994-07-15 00:00:00

  • Large-scale randomized prostate cancer screening trials: program performances in the European Randomized Screening for Prostate Cancer trial and the Prostate, Lung, Colorectal and Ovary cancer trial.

    abstract::Two large-scale randomized screening trials, the Prostate, Lung, Colorectal and Ovary (PLCO) cancer trial in the USA and the European Randomized Screening for Prostate Cancer (ERSPC) trial in Europe are currently under way, aimed at assessing whether screening reduces prostate cancer mortality. Up to the end of 1998, ...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: de Koning HJ,Auvinen A,Berenguer Sanchez A,Calais da Silva F,Ciatto S,Denis L,Gohagan JK,Hakama M,Hugosson J,Kranse R,Nelen V,Prorok PC,Schröder FH,European Randomized Screening for Prostate Cancer (ERSPC) Trial.,Internationa

    更新日期:2002-01-10 00:00:00

  • LAGE-1, a new gene with tumor specificity.

    abstract::Representational difference analysis was used to identify genes that are expressed in a human melanoma cell line and not in normal skin. A cDNA clone that appeared to be specific for tumors was obtained and the corresponding gene was sequenced. This new gene was named LAGE-I. Using a LAGE-I probe to screen a cDNA libr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lethé B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T

    更新日期:1998-06-10 00:00:00

  • Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment.

    abstract::Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration-resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels throug...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lubik AA,Nouri M,Truong S,Ghaffari M,Adomat HH,Corey E,Cox ME,Li N,Guns ES,Yenki P,Pham S,Buttyan R

    更新日期:2017-01-15 00:00:00

  • Tissue and serum metabolomic phenotyping for diagnosis and prognosis of hepatocellular carcinoma.

    abstract::More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T

    更新日期:2020-03-15 00:00:00

  • Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29.

    abstract::Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, biosynthetic pathways should be upregulated during cell cyc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vizán P,Alcarraz-Vizán G,Díaz-Moralli S,Solovjeva ON,Frederiks WM,Cascante M

    更新日期:2009-06-15 00:00:00

  • Diacylglycerols and the protein kinase inhibitor H-7 suppress cell polarity and locomotion of Walker 256 carcinosarcoma cells.

    abstract::We show that diacylglycerols, like phorbol myristate acetate (PMA), suppress cell polarity and locomotor activity of Walker carcinosarcoma cells in a dose-dependent fashion in vitro. OAG and diC8 show significant activity at concentrations above 3 x 10(-5) M. The inhibitory effect on locomotion is due to a reduction i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Keller HU,Zimmermann A,Niggli V

    更新日期:1989-11-15 00:00:00

  • Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer.

    abstract::Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kato K,Iida S,Uetake H,Takagi Y,Yamashita T,Inokuchi M,Yamada H,Kojima K,Sugihara K

    更新日期:2008-02-01 00:00:00

  • Microsatellite instability and pathological aspects of breast cancer.

    abstract::Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Contegiacomo A,Palmirotta R,De Marchis L,Pizzi C,Mastranzo P,Delrio P,Petrella G,Figliolini M,Bianco AR,Frati L

    更新日期:1995-08-22 00:00:00

  • Generation of tumoricidal PAX3 peptide antigen specific cytotoxic T lymphocytes.

    abstract::The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. Major histocompatibility complex (MHC) peptide bindi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rodeberg DA,Nuss RA,Elsawa SF,Erskine CL,Celis E

    更新日期:2006-07-01 00:00:00

  • Human melanoma cells express FGFR/Src/Rho signaling that entails an adhesion-independent caveolin-1 membrane association.

    abstract::Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fecchi K,Travaglione S,Spadaro F,Quattrini A,Parolini I,Piccaro G,Raggi C,Fabbri A,Felicetti F,Carè A,Fiorentini C,Sargiacomo M

    更新日期:2012-03-15 00:00:00

  • Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.

    abstract::A panel of monoclonal antibodies (MAbs) has been obtained, directed against determinants of normal human colorectal epithelium. BALB/c mice were immunized and boosted with mucosal scrapings and cell membrane preparations from normal large intestine. In one case boosting was also performed with HT29 colon carcinoma cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Richman PI,Bodmer WF

    更新日期:1987-03-15 00:00:00

  • Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11q deletion in tumors lacking MYCN amplification.

    abstract::We have studied the occurrence and association of 11q deletions with other chromosomal imbalances in Stage 4 neuroblastomas. To this purpose we have performed comparative genomic hybridization (CGH) analysis on 50 Stage 4 neuroblastomas and these data were analyzed together with those from 33 previously published case...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Plantaz D,Vandesompele J,Van Roy N,Lastowska M,Bown N,Combaret V,Favrot MC,Delattre O,Michon J,Bénard J,Hartmann O,Nicholson JC,Ross FM,Brinkschmidt C,Laureys G,Caron H,Matthay KK,Feuerstein BG,Speleman F

    更新日期:2001-03-01 00:00:00

  • LAF-4 is aberrantly expressed in human breast cancer.

    abstract::LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

    更新日期:2005-07-01 00:00:00

  • Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

    abstract::XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

    更新日期:2003-01-01 00:00:00

  • Clinicopathological characteristics of p53 overexpression in endometrial cancers.

    abstract::Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Inoue M,Okayama A,Fujita M,Enomoto T,Sakata M,Tanizawa O,Ueshima H

    更新日期:1994-07-01 00:00:00

  • Plasma C-peptide and glycated albumin and subsequent risk of cancer: From a large prospective case-cohort study in Japan.

    abstract::To elucidate the individual impacts of insulin and blood glucose on cancer risk, we investigated the association of plasma C-peptide, a surrogated marker of insulin and glycated albumin (GA), a more stable marker of blood glucose, with all-site and site-specific cancer risk by mutually accounting for their confounding...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hidaka A,Budhathoki S,Yamaji T,Sawada N,Tanaka-Mizuno S,Kuchiba A,Charvat H,Goto A,Shimazu T,Inoue M,Noda M,Tsugane S,Iwasaki M,JPHC Study Group.

    更新日期:2019-02-15 00:00:00

  • Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

    abstract::Antitumor immunity in chronic lymphocytic leukemia (CLL) is hampered by highly dysfunctional T-cells. Although certain T-cell subsets have been reported to be of prognostic significance in this disease, their interplay is complex and it remains incompletely understood which of these subsets significantly drive CLL pro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rissiek A,Schulze C,Bacher U,Schieferdecker A,Thiele B,Jacholkowski A,Flammiger A,Horn C,Haag F,Tiegs G,Zirlik K,Trepel M,Tolosa E,Binder M

    更新日期:2014-11-15 00:00:00