Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis.

abstract：:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

journal_title：International journal of cancer

authors： Ekblom P,Thesleff I,Lehto VP,Virtanen I

更新日期：1983-01-15 00:00:00

abstract：:A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...

journal_title：International journal of cancer

authors： Kotsopoulos J,Tworoger SS,De Vivo I,Hankinson SE,Hunter DJ,Willett WC,Chen WY

更新日期：2009-10-01 00:00:00

abstract：:We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale Univer...

journal_title：International journal of cancer

authors： Charpin C,Tavassoli F,Secq V,Giusiano S,Villeret J,Garcia S,Birnbaum D,Bonnier P,Lavaut MN,Boubli L,Carcopino X,Iovanna J

更新日期：2012-08-01 00:00:00

abstract：:BRMS1 is regarded as a metastasis suppressor gene for its ability to reduce metastatic potential of human and murine breast cancer cells as well as human melanoma cells. However, BRMS1 association to human tumor progression is not clearly understood. In the present study we analyzed BRMS1 mRNA expression in tumor prog...

journal_title：International journal of cancer

authors： Lombardi G,Di Cristofano C,Capodanno A,Iorio MC,Aretini P,Isola P,Tancredi M,Collecchi P,Naccarato AG,Porta RP,Bevilacqua G,Caligo MA

更新日期：2007-03-15 00:00:00

abstract：:Human mammary tumours which are histologically well differentiated are more likely to synthesize receptors for estrogen (ER) and progesterone (PR) and to respond to systemic endocrine therapy. The aim of this study was to explore the relationship between differentiation, receptors and endocrine responsiveness in more ...

journal_title：International journal of cancer

authors： Baildam AD,Howell A,Barnes DM,Redford J,Healy K,Swindell R,Sellwood RA

更新日期：1988-08-15 00:00:00

abstract：:Both the tumour growth and progression and the systemic inflammatory response have the potential to increase oxidative stress. We therefore examined the relationship between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n = 53...

journal_title：International journal of cancer

authors： Leung EY,Crozier JE,Talwar D,O'Reilly DS,McKee RF,Horgan PG,McMillan DC

更新日期：2008-11-15 00:00:00

abstract：:Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...

journal_title：International journal of cancer

authors： Stenman S,Vaheri A

更新日期：1981-01-01 00:00:00

abstract：:Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...

journal_title：International journal of cancer

authors： Zappasodi R,Cavanè A,Iorio MV,Tortoreto M,Guarnotta C,Ruggiero G,Piovan C,Magni M,Zaffaroni N,Tagliabue E,Croce CM,Zunino F,Gianni AM,Di Nicola M

更新日期：2014-11-01 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic line, CCRF-CEM-C7, by se...

journal_title：International journal of cancer

authors： Hala M,Hartmann BL,Böck G,Geley S,Kofler R

更新日期：1996-11-27 00:00:00

abstract：:Colonic tumors of human origin produce abundant transforming growth factor (TGF)-beta suggesting that TGF-beta is critical to their growth. Dietary lipids regulate a number of growth factors including TGF-beta. Whether elevated TGF-beta levels are consistently expressed in colonic tumors irrespective of the environmen...

journal_title：International journal of cancer

authors： Raju J,McCarthy B,Bird RP

更新日期：2002-08-20 00:00:00

abstract：:The recently identified cell adhesion regulator (CAR) modulates the process of integrin-mediated cell adhesion. The CAR gene is located on 16q, a locus at which high levels of allelic losses have been demonstrated in advanced human hepatocellular carcinoma (HCC). We studied the possible involvement of the CAR gene in ...

journal_title：International journal of cancer

authors： Yamamoto H,Itoh F,Sakamoto H,Nakajima Y,Une Y,Hinoda Y,Imai K

更新日期：1997-06-20 00:00:00

abstract：:Twenty-seven human colorectal adenocarcinomas were implanted s.c. into nude mice. A comparative study of chromosomes and DNA between fresh tumor (FT) and xenografted tumor cells (XT) could be performed in 9 cases. Losses or deletions were consistently found in FTs as well as in XTs, particularly on chromosomes 17 and/...

journal_title：International journal of cancer

authors： Lefrançois D,Olschwang S,Delattre O,Muleris M,Dutrillaux AM,Thomas G,Dutrillaux B

更新日期：1989-11-15 00:00:00

abstract：:Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...

journal_title：International journal of cancer

authors： Wu CS,Lu YJ,Li HP,Hsueh C,Lu CY,Leu YW,Liu HP,Lin KH,Hui-Ming Huang T,Chang YS

更新日期：2010-06-01 00:00:00

abstract：:We report the incidence of cervical intraepithelial neoplasia (CIN) among HIV-infected women who did not have any colposcopic or histopathological evidence of CIN at baseline. Of the 1,023 women without any CIN at baseline, 855 (83.6%) have been followed up to a maximum of 6.4 years contributing 2,875 person years of ...

journal_title：International journal of cancer

authors： Joshi S,Muwonge R,Kulkarni V,Deodhar K,Mandolkar M,Lucas E,Sankaranarayanan R

更新日期：2019-03-01 00:00:00

abstract：:Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

journal_title：International journal of cancer

authors： Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

更新日期：1993-12-02 00:00:00

abstract：:India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...

journal_title：International journal of cancer

authors： Campos NG,Tsu V,Jeronimo J,Regan C,Resch S,Clark A,Sy S,Kim JJ

更新日期：2019-02-15 00:00:00

abstract：:Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...

journal_title：International journal of cancer

authors： Ryan MP,Higgins PJ

更新日期：1988-08-15 00:00:00

abstract：:Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is little direct evidence on how the genetic heterogeneity impacts on drug response profiles of the cancer cells. Our goal was to determine how genomic clonal evolution...

journal_title：International journal of cancer

authors： Saeed K,Ojamies P,Pellinen T,Eldfors S,Turkki R,Lundin J,Järvinen P,Nisen H,Taari K,Af Hällström TM,Rannikko A,Mirtti T,Kallioniemi O,Östling P

更新日期：2019-03-15 00:00:00

abstract：:Three human ovarian cancer xenografts of different origin and grown s.c. in nude mice as well-established tumors were studied for their sensitivity to cisplatin (CDDP), cyclophosphamide (CTX), 131I-labelled anti-episialin monoclonal antibody (MAb) 139H2, or external-beam radiotherapy. The maximum tolerated dose of CDD...

journal_title：International journal of cancer

authors： Molthoff CF,Pinedo HM,Schlüper HM,Rutgers DH,Boven E

更新日期：1992-04-22 00:00:00

abstract：:Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...

journal_title：International journal of cancer

authors： Staib L,Birebent B,Somasundaram R,Purev E,Braumüller H,Leeser C,Küttner N,Li W,Zhu D,Diao J,Wunner W,Speicher D,Beger HG,Song H,Herlyn D

更新日期：2001-04-01 00:00:00

abstract：:In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...

journal_title：International journal of cancer

authors： Ureta-Vidal A,Angelin-Duclos C,Tortevoye P,Murphy E,Lepère JF,Buigues RP,Jolly N,Joubert M,Carles G,Pouliquen JF,de Thé G,Moreau JP,Gessain A

更新日期：1999-09-09 00:00:00

abstract：:The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...

journal_title：International journal of cancer

authors： Hall P,Rosendahl I,Mattsson A,Einhorn S

更新日期：1995-09-04 00:00:00

abstract：:Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...

journal_title：International journal of cancer

authors： Haliotis T,Ball JK,Dexter D,Roder JC

更新日期：1985-04-15 00:00:00

abstract：:NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...

journal_title：International journal of cancer

authors： Wang W,Li Y,Li Y,Hong A,Wang J,Lin B,Li R

更新日期：2009-02-01 00:00:00

abstract：:Our aim was to analyze the expression of the serine protease HtrA1 in human bladder tissue and urine in order to point out its possible association with the presence of urothelial bladder cancer. Bladder tissue and urine specimens from cancer patients with different tumor grades and stages (n = 68) and from individual...

journal_title：International journal of cancer

authors： Lorenzi T,Lorenzi M,Altobelli E,Marzioni D,Mensà E,Quaranta A,Paolinelli F,Morroni M,Mazzucchelli R,De Luca A,Procopio AD,Baldi A,Muzzonigro G,Montironi R,Castellucci M

更新日期：2013-12-01 00:00:00

abstract：:In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

journal_title：International journal of cancer

authors： Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

更新日期：2020-05-01 00:00:00

abstract：:More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor s...

journal_title：International journal of cancer

authors： Kinouchi M,Izumi S,Nakashiro KI,Haruyama Y,Kobashi G,Uchida D,Hasegawa T,Kawamata H

更新日期：2018-11-15 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

journal_title：International journal of cancer

authors： Tsai WS,Nagawa H,Muto T

更新日期：1997-01-27 00:00:00

abstract：:Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

journal_title：International journal of cancer

authors： Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

更新日期：2012-06-15 00:00:00