tRNA-based prognostic score in predicting survival outcomes of lung adenocarcinomas.

abstract：:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...

journal_title：International journal of cancer

authors： Kiselyov A,Bunimovich-Mendrazitsky S,Startsev V

更新日期：2016-06-01 00:00:00

abstract：:Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...

journal_title：International journal of cancer

authors： Nakadate H,Yokomori K,Watanabe N,Tsuchiya T,Namiki T,Kobayshi H,Suita S,Tsunematsu Y,Horikoshi Y,Hatae Y,Endo M,Komada Y,Eguchi H,Toyoda Y,Kikuta A,Kobayashi R,Kaneko Y

更新日期：2001-11-01 00:00:00

abstract：:Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1 and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation between the number of FGFR2 minor alleles a...

journal_title：International journal of cancer

authors： Gates MA,Tworoger SS,Terry KL,De Vivo I,Hunter DJ,Hankinson SE,Cramer DW

更新日期：2009-02-01 00:00:00

abstract：:The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...

journal_title：International journal of cancer

authors： Lee HP,Gourley L,Duffy SW,Esteve J,Lee J,Day NE

更新日期：1994-12-01 00:00:00

abstract：:The role of miRNAs with tumor suppressive activity in liver cancer has been well studied. However, little is known about potential oncomiRs in HCC. In our study, we conducted a systematic evaluation of candidate oncomiRs and found that upregulation of miR-18a and miR-25 in HCC was associated with poor patient survival...

journal_title：International journal of cancer

authors： Sanchez-Mejias A,Kwon J,Chew XH,Siemens A,Sohn HS,Jing G,Zhang B,Yang H,Tay Y

更新日期：2019-01-15 00:00:00

abstract：:Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...

journal_title：International journal of cancer

authors： Chen YM,Shiu JY,Tzeng SJ,Shih LS,Chen YJ,Lui WY,Chen PH

更新日期：1998-03-02 00:00:00

abstract：:Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of response to fluoropyrimidine chemotherapy. Fluoropyrimidine drug toxicit...

journal_title：International journal of cancer

authors： Lincoln DW 2nd,Hrushesky WJ,Wood PA

更新日期：2000-11-01 00:00:00

abstract：:Suramin has been shown to have antiproliferative activity, either by blocking the binding of growth factors to their receptors or by inhibiting critical cellular enzymes. In 6 different cell lines from 5 tumour types (MCF-7, MCF-7/ADRR, PC3, HT-29, UM-SCC-11B and SW-1573/IR500), we studied the effect of scheduling of ...

journal_title：International journal of cancer

authors： Lopez Lopez R,Peters GJ,van Loenen AC,Pizao PE,van Rijswijk RE,Wagstaff J,Pinedo HM

更新日期：1992-07-30 00:00:00

abstract：:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

journal_title：International journal of cancer

authors： Smith SD,Rosen D

更新日期：1979-04-15 00:00:00

abstract：:Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...

journal_title：International journal of cancer

authors： Kyo S,Kanaya T,Takakura M,Tanaka M,Yamashita A,Inoue H,Inoue M

更新日期：1999-03-15 00:00:00

abstract：:In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...

journal_title：International journal of cancer

authors： Ureta-Vidal A,Angelin-Duclos C,Tortevoye P,Murphy E,Lepère JF,Buigues RP,Jolly N,Joubert M,Carles G,Pouliquen JF,de Thé G,Moreau JP,Gessain A

更新日期：1999-09-09 00:00:00

abstract：:Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutica...

journal_title：International journal of cancer

authors： Faisst S,Guittard D,Benner A,Cesbron JY,Schlehofer JR,Rommelaere J,Dupressoir T

更新日期：1998-02-09 00:00:00

abstract：:RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TM...

journal_title：International journal of cancer

authors： Wagner NB,Weide B,Reith M,Tarnanidis K,Kehrel C,Lichtenberger R,Pflugfelder A,Herpel E,Eubel J,Ikenberg K,Busch C,Holland-Letz T,Naeher H,Garbe C,Umansky V,Enk A,Utikal J,Gebhardt C

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrophoretic mobility of the open and covalently closed circular forms of ...

journal_title：International journal of cancer

authors： Marin JJ,Macias RI,Criado JJ,Bueno A,Monte MJ,Serrano MA

更新日期：1998-10-29 00:00:00

abstract：:Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

journal_title：International journal of cancer

authors： Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

更新日期：2020-09-01 00:00:00

abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

journal_title：International journal of cancer

authors： Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

更新日期：1999-01-05 00:00:00

abstract：:Natural killer (NK) cells exhibit strong cytotoxic activity against tumor cells without prior sensitization, and have the potential to exert antibody-dependent cellular cytotoxicity (ADCC). In this clinical trial, we examined the safety and efficacy of the use of NK cells, generated using a novel expansion system, in ...

journal_title：International journal of cancer

authors： Ishikawa T,Okayama T,Sakamoto N,Ideno M,Oka K,Enoki T,Mineno J,Yoshida N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Konishi H,Kokura S,Uno K,Naito Y,Itoh Y

更新日期：2018-06-15 00:00:00

abstract：:Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of th...

journal_title：International journal of cancer

authors： Eng C,Bessudo A,Hart LL,Severtsev A,Gladkov O,Müller L,Kopp MV,Vladimirov V,Langdon R,Kotiv B,Barni S,Hsu C,Bolotin E,von Roemeling R,Schwartz B,Bendell JC

更新日期：2016-07-01 00:00:00

abstract：:A panel of monoclonal antibodies (MAbs) has been obtained, directed against determinants of normal human colorectal epithelium. BALB/c mice were immunized and boosted with mucosal scrapings and cell membrane preparations from normal large intestine. In one case boosting was also performed with HT29 colon carcinoma cel...

journal_title：International journal of cancer

authors： Richman PI,Bodmer WF

更新日期：1987-03-15 00:00:00

abstract：:Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...

journal_title：International journal of cancer

authors： Harding MW,Yang TJ

更新日期：1981-03-15 00:00:00

abstract：:An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...

journal_title：International journal of cancer

authors： Viswanathan AN,Feskanich D,De Vivo I,Hunter DJ,Barbieri RL,Rosner B,Colditz GA,Hankinson SE

更新日期：2005-05-10 00:00:00

abstract：:The role of spontaneous and induced abortion on breast cancer risk is examined among 267,361 women recruited into the European Prospective Investigation into Cancer and nutrition between 1992 and 2000. The data were collected from 20 centers, across 9 countries, and included information on a total of 4,805 women with ...

journal_title：International journal of cancer

authors： Reeves GK,Kan SW,Key T,Tjønneland A,Olsen A,Overvad K,Peeters PH,Clavel-Chapelon F,Paoletti X,Berrino F,Krogh V,Palli D,Tumino R,Panico S,Vineis P,Gonzalez CA,Ardanaz E,Martinez C,Amiano P,Quiros JR,Tormo MR,Kha

更新日期：2006-10-01 00:00:00

abstract：:We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present study, we have found that this difference in expression is part...

journal_title：International journal of cancer

authors： Lee PS,Teaberry VS,Bland AE,Huang Z,Whitaker RS,Baba T,Fujii S,Secord AA,Berchuck A,Murphy SK

更新日期：2010-03-15 00:00:00

abstract：:HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...

journal_title：International journal of cancer

authors： Elahi A,Zhang L,Yeatman TJ,Gery S,Sebti S,Shibata D

更新日期：2008-04-01 00:00:00

abstract：:We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...

journal_title：International journal of cancer

authors： Nordlander C,Karlsson S,Karlsson A,Sjöling A,Winnes M,Klinga-Levan K,Behboudi A

更新日期：2007-04-01 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:This large population-based study compared breast-conserving surgery with radiation therapy (BCT) with mastectomy on (long-term) breast cancer-specific (BCSS) and overall survival (OS), and investigated the influence of several prognostic factors. Patients with primary T1-2N0-2M0 breast cancer, diagnosed between 1999 ...

journal_title：International journal of cancer

authors： Lagendijk M,van Maaren MC,Saadatmand S,Strobbe LJA,Poortmans PMP,Koppert LB,Tilanus-Linthorst MMA,Siesling S

更新日期：2018-01-01 00:00:00

abstract：:Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) w...

journal_title：International journal of cancer

authors： Sun Z,Liu H,Luo C,Geng L,Zheng C,Tang B,Zhu X,Tong J,Wang X,Ding K,Wan X,Zhang L,Yao W,Song K,Zhang X,Wu Y,Yang H,Han Y,Liu X,Zhu W,Wu J,Wang Z

更新日期：2018-08-01 00:00:00

abstract：:Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

journal_title：International journal of cancer

authors： Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

更新日期：2008-12-15 00:00:00

abstract：:Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...

journal_title：International journal of cancer

authors： Guenther A,Gordon S,Tiemann M,Burger R,Bakker F,Green JR,Baum W,Roelofs AJ,Rogers MJ,Gramatzki M

更新日期：2010-01-01 00:00:00