Abstract:
:Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI reactivity to CTVS antigen extract of spleen, draining and non-draining lymph-node cells, and peripheral blood leukocytes of regressors (non-adherence index--NAI of 172.8 +/- 46.8, 148.1 +/- 64.7, 138.7 +/- 47.3, and 172.2 +/- 60.7, respectively) was significantly greater than that of progressors (46.1 +/- 20.0, 38.5 +/- 21.5, 50.2 +/- 30.0, 24,6 +/- 37.2, respectively, p less than 0.001) and normal dogs (47.5 +/- 22.8, 54.6 +/- 24.6, 26.7 +/- 14.0, 50.9 +/- 22.4, respectively, p less than 0.001). In contrast, LAI reactivity of progressor lymphoid tissues to CTVS antigen extract did not differ significantly from that of normal dogs. LAI reactivity of lymphoid tissues from steady state tumor bearers (97.9 +/- 39.2, 80.7 +/- 47.3, 87.1 +/- 40.0, 85.1 +/- 53,9, respectively) was intermediate between and significantly different from LAI reactivities of regressor (p less than 0.05) and progressor (p less than 0.01) lymphoid tissues. Significant LAI reactivity observed in regressors suggests the presence of a functional effector cell mechanism associated with spontaneous regression of CTVS. The three distinct patterns of LAI reactivity observed in tumor-bearing dogs appear to correlate with the clinical course of tumor growth.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Harding MW,Yang TJdoi
10.1002/ijc.2910270314subject
Has Abstractpub_date
1981-03-15 00:00:00pages
349-55issue
3eissn
0020-7136issn
1097-0215journal_volume
27pub_type
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journal_title:International journal of cancer
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