HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women.


:A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neoplasia. HLA-B15 was found to be protective for CIN III/ICC overall (p(corrected) = 0.003), and for HPV52-positive CIN III/ICC (p(corrected) = 0.003). A marginal protective effect of B15 was observed for HPV16-positive CIN III/ICC, but no significant associations were revealed for HPV18- or HPV58-positive cases. None of the HLA-B alleles were found to confer an increased risk for cervical neoplasia. HLA-B15 is common among Asian for whom HPV52, a worldwide uncommon HPV type, also exists in a relatively high prevalence. It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations.


Int J Cancer


Chan PK,Cheung JL,Cheung TH,Lin CK,Tam AO,Chan DP,Zhou DX,Lo KW,Yim SF,Siu SS





Has Abstract


2006-03-15 00:00:00












  • Studies of genetic transmission of mammary tumour virus by C3Hf mice.

    abstract::By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van Nie R,Verstraeten AA

    更新日期:1975-12-15 00:00:00

  • A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses.

    abstract::This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo YL,van den Hende M,Sterling JC,Coleman N,Crawford RA,Kwappenberg KM,Stanley MA,van der Burg SH

    更新日期:2010-01-01 00:00:00

  • Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.

    abstract::CXCR1 and CXCR2 are receptors for CXCL-8 and are differentially expressed on melanoma and endothelial cells. In this study, we determined the functional role of these receptors in melanoma progression. We stably knock-down the expression of CXCR1 and/or CXCR2 in A375-SM (SM; high metastatic) human melanoma cells by sh...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Singh S,Sadanandam A,Varney ML,Nannuru KC,Singh RK

    更新日期:2010-01-15 00:00:00

  • Cigarette smoking, alcohol consumption and primary liver cancer: a case-control study in the USA.

    abstract::Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was obser...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yu H,Harris RE,Kabat GC,Wynder EL

    更新日期:1988-09-15 00:00:00

  • A simple and effective method for cancer immunotherapy by inactivated allogeneic leukocytes infusion.

    abstract::Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Su X,Guo S,Zhou C,Wang D,Ma W,Zhang S

    更新日期:2009-03-01 00:00:00

  • DT-diaphorase as a determinant of sensitivity to adriamycin in non-small-cell lung-cancer cell lines.

    abstract::We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kasahara K,Shibata K,Bando T,Numata Y,Fujimura M,Matsuda T

    更新日期:1994-10-15 00:00:00

  • Modulation of immune parameters in patients with metastatic renal-cell cancer receiving combination immunotherapy (IL-2, IFN alpha and autologous IL-2-activated lymphocytes).

    abstract::We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

    更新日期:1996-01-17 00:00:00

  • Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance.

    abstract::Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSC...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Singh AK,Arya RK,Maheshwari S,Singh A,Meena S,Pandey P,Dormond O,Datta D

    更新日期:2015-05-01 00:00:00

  • Variation in promptness of presentation among 10,297 patients subsequently diagnosed with one of 18 cancers: evidence from a National Audit of Cancer Diagnosis in Primary Care.

    abstract::Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

    更新日期:2014-09-01 00:00:00

  • High cell kinetics is associated with amplification of the int-2, bcl-1, myc and erbB-2 proto-oncogenes and loss of heterozygosity at the DF3 locus in primary breast cancers.

    abstract::Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Contegiacomo A,Pizzi C,De Marchis L,Alimandi M,Delrio P,Di Palma E,Petrella G,Ottini L,French D,Frati L

    更新日期:1995-03-29 00:00:00

  • No evidence for association of NOD2 R702W and G908R with colorectal cancer.

    abstract::Polymorphisms in nucleotide oligomerization domain 2 gene (NOD2) have been associated with increased susceptibility to Crohn's disease. Recently, possible association of the NOD2 variants R702W, G908R and 3020insC with colorectal cancer (CRC) has been studied among Polish, Greek, Finnish and New Zealand Caucasian CRC ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tuupanen S,Alhopuro P,Mecklin JP,Järvinen H,Aaltonen LA

    更新日期:2007-07-01 00:00:00

  • Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells.

    abstract::In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

    更新日期:2018-11-15 00:00:00

  • Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients.

    abstract::Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: García-Sanz R,González-Fraile MI,Mateo G,Hernández JM,López-Berges MC,de las Heras N,Fernández-Calvo J,Ortega F,Portero JA,Bárez A,Galende J,Orfão A,San Miguel JF

    更新日期:2004-12-10 00:00:00

  • Production of T-cell lines with inhibitory or stimulatory activity against syngeneic tumors in vivo. A preliminary report.

    abstract::We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cult...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mulé JJ,Forstrom JW,George E,Hellström I,Hellström KE

    更新日期:1981-11-15 00:00:00

  • Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase.

    abstract::Recently, pegylated arginine deiminase (ADI; EC has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoon CY,Shim YJ,Kim EH,Lee JH,Won NH,Kim JH,Park IS,Yoon DK,Min BH

    更新日期:2007-02-15 00:00:00

  • Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.

    abstract::Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

    更新日期:2012-01-15 00:00:00

  • The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice.

    abstract::Malignant cells possess a high degree of proteolytic activity in which the plasminogen activator system plays an important role. An increased expression of urokinase type plasminogen activator (uPA) is of significance for degradation of the extracellular tumor matrix, facilitating invasiveness and growth. Inhibition o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Billström A,Hartley-Asp B,Lecander I,Batra S,Astedt B

    更新日期:1995-05-16 00:00:00

  • Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).

    abstract::ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schaefer C,Butterfield LH,Lee S,Kim GG,Visus C,Albers A,Kirkwood JM,Whiteside TL

    更新日期:2012-08-15 00:00:00

  • Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study.

    abstract::Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

    更新日期:2015-03-01 00:00:00

  • Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility.

    abstract::Tumor cell motility is one of the rate-limiting steps of invasion, which defines progression toward a more malignant phenotype. Elevated expression of epidermal growth factor receptor (EGFR) in many cancers is associated with progression of superficial to invasive forms of the disease. The naturally occuring type III ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pedersen MW,Tkach V,Pedersen N,Berezin V,Poulsen HS

    更新日期:2004-02-20 00:00:00

  • Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas.

    abstract::Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. The CpG ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoon JH,Dammann R,Pfeifer GP

    更新日期:2001-10-15 00:00:00

  • Serum and salivary IgA antibodies against a defined epitope of the Epstein-Barr virus nuclear antigen (EBNA) are elevated in nasopharyngeal carcinoma.

    abstract::The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

    更新日期:1990-06-15 00:00:00

  • Alcohol consumption and colon cancer prognosis among participants in north central cancer treatment group phase III trial N0147.

    abstract::Alcohol consumption is associated with a modest increased risk of colon cancer, but its relationship with colon cancer survival has not been elucidated. Using data from a phase III randomized adjuvant trial, we assessed the association of alcohol consumption with colon cancer outcomes. Patients completed a risk factor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Phipps AI,Shi Q,Limburg PJ,Nelson GD,Sargent DJ,Sinicrope FA,Chan E,Gill S,Goldberg RM,Kahlenberg M,Nair S,Shields AF,Newcomb PA,Alberts SR,Alliance for Clinical Trials in Oncology.

    更新日期:2016-09-01 00:00:00

  • Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.

    abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

    更新日期:2020-05-01 00:00:00

  • Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11q deletion in tumors lacking MYCN amplification.

    abstract::We have studied the occurrence and association of 11q deletions with other chromosomal imbalances in Stage 4 neuroblastomas. To this purpose we have performed comparative genomic hybridization (CGH) analysis on 50 Stage 4 neuroblastomas and these data were analyzed together with those from 33 previously published case...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Plantaz D,Vandesompele J,Van Roy N,Lastowska M,Bown N,Combaret V,Favrot MC,Delattre O,Michon J,Bénard J,Hartmann O,Nicholson JC,Ross FM,Brinkschmidt C,Laureys G,Caron H,Matthay KK,Feuerstein BG,Speleman F

    更新日期:2001-03-01 00:00:00

  • Mammographic screening after the age of 65 years: evidence for a reduction in breast cancer mortality.

    abstract::We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

    更新日期:1996-06-11 00:00:00

  • Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time.

    abstract::Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Shabo I,Olsson H,Sun XF,Svanvik J

    更新日期:2009-10-15 00:00:00

  • NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth.

    abstract::NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang W,Li Y,Li Y,Hong A,Wang J,Lin B,Li R

    更新日期:2009-02-01 00:00:00

  • All-trans, 13-cis and 9-cis retinoic acids induce a fully reversible growth inhibition in HNSCC cell lines: implications for in vivo retinoic acid use.

    abstract::Retinoids are a group of vitamin A analogues that have shown promise as chemopreventive and therapeutic agents in many types of malignancy and have been entered in clinical trials with some successful results. To better understand the mechanism that mediates retinoid action and the anti-proliferative effects, we treat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giannini F,Maestro R,Vukosavljevic T,Pomponi F,Boiocchi M

    更新日期:1997-01-17 00:00:00

  • Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder.

    abstract::Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 sa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Patard JJ,Brasseur F,Gil-Diez S,Radvanyi F,Marchand M,François P,Abi-Aad A,Van Cangh P,Abbou CC,Chopin D

    更新日期:1995-02-20 00:00:00