HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women.

abstract：:The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high-grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case-control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16...

journal_title：International journal of cancer

authors： van Duin M,Snijders PJ,Schrijnemakers HF,Voorhorst FJ,Rozendaal L,Nobbenhuis MA,van den Brule AJ,Verheijen RH,Helmerhorst TJ,Meijer CJ

更新日期：2002-04-01 00:00:00

abstract：:Interferon-beta (IFN-beta) has been used as an antitumor drug against human glioma, melanoma and medulloblastoma since the 1980s. Recently, we developed a new gene therapy using the IFN-beta gene against malignant gliomas and then began clinical trials in 2000. Since stimulation of immune system was one mechanism of a...

journal_title：International journal of cancer

authors： Saito R,Mizuno M,Nakahara N,Tsuno T,Kumabe T,Yoshimoto T,Yoshida J

更新日期：2004-09-20 00:00:00

abstract：:Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...

journal_title：International journal of cancer

authors： Tokuda K,Natsugoe S,Shimada M,Kumanohoso T,Baba M,Takao S,Nakamura K,Yamada K,Yoshizawa H,Hatate Y,Aikou T

更新日期：1998-05-29 00:00:00

abstract：:Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...

journal_title：International journal of cancer

authors： Meder L,König K,Ozretić L,Schultheis AM,Ueckeroth F,Ade CP,Albus K,Boehm D,Rommerscheidt-Fuss U,Florin A,Buhl T,Hartmann W,Wolf J,Merkelbach-Bruse S,Eilers M,Perner S,Heukamp LC,Buettner R

更新日期：2016-02-15 00:00:00

abstract：:Smoking is a major contributor to all-cause mortality in Europe and accounts for one-fifth of the cancer-related deaths. Monitoring the tobacco epidemic via an analysis of lung cancer trends is essential in helping countries arrest the effects of tobacco epidemic in the region. The study aims to provide a comprehensiv...

journal_title：International journal of cancer

authors： Bray FI,Weiderpass E

更新日期：2010-03-15 00:00:00

abstract：:Pre-malignant and malignant human colorectal tumour epithelial cell lines both secreted precursor forms of the 2 cysteine proteinases, cathepsins B and L. The amount of proteinases secreted by these cell lines varied according to the cell density. Comparison at similar cell densities showed that the pre-malignant, ade...

journal_title：International journal of cancer

authors： Maciewicz RA,Wardale RJ,Etherington DJ,Paraskeva C

更新日期：1989-03-15 00:00:00

abstract：:A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...

journal_title：International journal of cancer

authors： Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NE

更新日期：1985-05-15 00:00:00

abstract：:The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...

journal_title：International journal of cancer

authors： Zeng J,Müller-Berghaus J,Nguyen XD,Klüter H,Schönhaber H,Song M,Schwinn N,Schadendorf D,Goerdt S,Eichmüller S,Dippel E

更新日期：2006-11-15 00:00:00

abstract：:The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...

journal_title：International journal of cancer

authors： Fuxe J,Liu L,Malin S,Philipson L,Collins VP,Pettersson RF

更新日期：2003-03-01 00:00:00

abstract：:The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridizati...

journal_title：International journal of cancer

authors： Carbone G,Borrello MG,Molla A,Rizzetti MG,Pierotti MA,Della Porta G,Parmiani G

更新日期：1991-02-20 00:00:00

abstract：:Invasion of malignant cells requires altered cellular interaction with extracellular matrix. Integrin-type cell adhesion receptors play an important role in this process. Integrin-related cell biological phenomena explain cancer cell migration, and recent developments in the field have made it possible to propose that...

journal_title：International journal of cancer

authors： Heino J

更新日期：1996-03-15 00:00:00

abstract：:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...

journal_title：International journal of cancer

authors： Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

更新日期：1996-03-01 00:00:00

abstract：:The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...

journal_title：International journal of cancer

authors： de Cremoux P,Gauville C,Closson V,Linares G,Calvo F,Tavitian A,Olofsson B

更新日期：1994-11-01 00:00:00

abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

journal_title：International journal of cancer

authors： Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

更新日期：2000-04-01 00:00:00

abstract：:Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...

journal_title：International journal of cancer

authors： Cleveland PH,Belnap LP,Knotts FB,Nayak SK,Baird SM,Pilch YH

更新日期：1979-03-15 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects agains...

journal_title：International journal of cancer

authors： Seo HJ,Park KK,Han SS,Chung WY,Son MW,Kim WB,Surh YJ

更新日期：2002-08-01 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

journal_title：International journal of cancer

authors： Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

更新日期：2018-10-15 00:00:00

abstract：:The role of MHC-class-I-antigen expression in intracerebral anti-tumor natural resistance was examined using MHC-positive Lym+ and MHC-negative Lym- lymphoma cell lines. Lym+ was sensitive to MHC-class-I-restricted CTL-mediated lysis, while lym- was resistant. Both lines were susceptible to NK-cell-mediated lysis. The...

journal_title：International journal of cancer

authors： Yamasaki T,Akiyama Y,Fukuda M,Kimura Y,Moritake K,Kikuchi H,Ljunggren HG,Kärre K,Klein G

更新日期：1996-07-29 00:00:00

abstract：:Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...

journal_title：International journal of cancer

authors： Deauvieau F,Ollion V,Doffin AC,Achard C,Fonteneau JF,Verronese E,Durand I,Ghittoni R,Marvel J,Dezutter-Dambuyant C,Walzer T,Vie H,Perrot I,Goutagny N,Caux C,Valladeau-Guilemond J

更新日期：2015-03-01 00:00:00

abstract：:Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone EO9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of EO9 and mitomycin C in...

journal_title：International journal of cancer

authors： Plumb JA,Workman P

更新日期：1994-01-02 00:00:00

abstract：:To elucidate the individual impacts of insulin and blood glucose on cancer risk, we investigated the association of plasma C-peptide, a surrogated marker of insulin and glycated albumin (GA), a more stable marker of blood glucose, with all-site and site-specific cancer risk by mutually accounting for their confounding...

journal_title：International journal of cancer

authors： Hidaka A,Budhathoki S,Yamaji T,Sawada N,Tanaka-Mizuno S,Kuchiba A,Charvat H,Goto A,Shimazu T,Inoue M,Noda M,Tsugane S,Iwasaki M,JPHC Study Group.

更新日期：2019-02-15 00:00:00

abstract：:TP53 accumulation in human primary breast carcinomas was studied by a quantitative luminometric immunoassay (LIA), and TP53 gene alterations, exons 5-8, were examined by single-strand conformation polymorphism (SSCP) analysis. In 48 of 142 breast tumor samples, a TP53 gene alteration was identified. In tumor samples w...

journal_title：International journal of cancer

authors： de Witte HH,Foekens JA,Lennerstrand J,Smid M,Look MP,Klijn JG,Benraad TJ,Berns EM

更新日期：1996-04-22 00:00:00

abstract：:We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...

journal_title：International journal of cancer

authors： Colombatti A,Collavo D,Biasi G,Chieco-Bianchi L

更新日期：1975-09-15 00:00:00

abstract：:MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

journal_title：International journal of cancer

authors： Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

更新日期：2012-06-01 00:00:00

abstract：:Over-expression of the HER2/neu (HER2) proto-oncogene in breast carcinoma imparts an enhanced metastatic potential. Metastasis requires escape of the tumor cell from the vasculature into subjacent tissue, a transmigration event across an endothelial cell (EC) monolayer. EC retraction has been reported to precede trans...

journal_title：International journal of cancer

authors： Carter WB,Hoying JB,Boswell C,Williams SK

更新日期：2001-02-01 00:00:00

abstract：:Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...

journal_title：International journal of cancer

authors： Fetahu IS,Tennakoon S,Lines KE,Gröschel C,Aggarwal A,Mesteri I,Baumgartner-Parzer S,Mader RM,Thakker RV,Kállay E

更新日期：2016-01-01 00:00:00

abstract：:The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...

journal_title：International journal of cancer

authors： Ugorski M,Påhlsson P,Dus D,Nilsson B,Skouv J,Radzikowski C

更新日期：1990-06-15 00:00:00

abstract：:The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...

journal_title：International journal of cancer

authors： Lee HP,Gourley L,Duffy SW,Esteve J,Lee J,Day NE

更新日期：1994-12-01 00:00:00