Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines.

abstract：:Laser scanning confocal microscopy has been used to follow the uptake and efflux of the 2-fluoroglycoside of doxorubicin, ME2303, in live cultures of the human ovarian cancer cell line A2780 and its doxorubicin-resistant variant A2780AD. Our methods combine confocal laser scanning microscopy and image analysis to exam...

journal_title：International journal of cancer

authors： Huxham IM,Barlow AL,Lewis AD,Plumb J,Mairs RJ,Gaze MN,Workman P

更新日期：1994-10-01 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...

journal_title：International journal of cancer

authors： Zariwala M,Schmid S,Pfaltz M,Ohgaki H,Kleihues P,Schäfer R

更新日期：1994-03-15 00:00:00

abstract：:Murine SCC-VII squamous carcinoma cells have the capacity to penetrate reconstituted basement membranes (Matrigel) in vitro. The invasion of Matrigel layers by SCC-VII cells was significantly reduced by E-64, a specific inhibitor of lysosomal cysteine proteinases. The cathepsin-B-selective E-64 derivative, CA-074, inh...

journal_title：International journal of cancer

authors： Coulibaly S,Schwihla H,Abrahamson M,Albini A,Cerni C,Clark JL,Ng KM,Katunuma N,Schlappack O,Glössl J,Mach L

更新日期：1999-11-12 00:00:00

abstract：:Tumor cells do not constitutively exhibit invasive activity, but rather, can be transiently induced to adhere and form lesions. We report here that the expression of seprase, a dominant EDTA-resistant gelatinase in malignant tumors, is dependent on tumor cell exposure to type I collagen gel (TICg). The induced seprase...

journal_title：International journal of cancer

authors： Kennedy A,Dong H,Chen D,Chen WT

更新日期：2009-01-01 00:00:00

abstract：:In this report, we quantified HTLV-I provirus load using the AmpliSensor system, which utilizes fluorescence to measure PCR products. With this method, provirus loads could be measured within 6 hr, and the results obtained correlated well with those obtained by other methods. Samples from 256 blood donors, who were po...

journal_title：International journal of cancer

authors： Etoh K,Yamaguchi K,Tokudome S,Watanabe T,Okayama A,Stuver S,Mueller N,Takatsuki K,Matsuoka M

更新日期：1999-06-11 00:00:00

abstract：:The prevalence of methylation of the p16, DAPK and RASSF1A genes was investigated in lung adenocarcinoma from smokers, former uranium miners and never smokers. The association between a common genetic alteration in adenocarcinoma, mutation of the K-ras gene and methylation of these genes, as well as survival was exami...

journal_title：International journal of cancer

authors： Divine KK,Pulling LC,Marron-Terada PG,Liechty KC,Kang T,Schwartz AG,Bocklage TJ,Coons TA,Gilliland FD,Belinsky SA

更新日期：2005-04-10 00:00:00

abstract：:Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. We genotyped 837 melanoma cases and 1,154 controls for 21 single nucleotide polymorphisms (SNPs) informative for 495 polymorphisms at the locus. Our data showe...

journal_title：International journal of cancer

authors： Maccioni L,Rachakonda PS,Scherer D,Bermejo JL,Planelles D,Requena C,Hemminki K,Nagore E,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 midd...

journal_title：International journal of cancer

authors： Moy KA,Yuan JM,Chung FL,Wang XL,Van Den Berg D,Wang R,Gao YT,Yu MC

更新日期：2009-12-01 00:00:00

abstract：:Human papillomavirus (HPV) is a circular double-stranded DNA virus implicated in at least 90% of cervical and anogenital cancers and has been observed in approximately 20% of squamous cell carcinomas of the head and neck (SCCHN). Transcription of the viral oncogenes E6 and E7 is regulated by expression of the E2 prote...

journal_title：International journal of cancer

authors： Ragin CC,Reshmi SC,Gollin SM

更新日期：2004-07-10 00:00:00

abstract：:DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of ANLL; 4 GGT----GAT tr...

journal_title：International journal of cancer

authors： Senn HP,Trân-Thang C,Wodnar-Filipowicz A,Jiricny J,Fopp M,Gratwohl A,Signer E,Weber W,Moroni C

更新日期：1988-01-15 00:00:00

abstract：:In combination with xenogeneic immune RNA (l-RNA) and tumor antigen (TA), syngeneic spleen cells inhibited the growth of a N-methyl-N-nitrosourethane-induced colon carcinoma (CT-26) in BALB/c mice. The sequential administration of 1 X 10(7) spleen cells, l mg of anti-CT-26 l-RNA and 0.4 mg of CT-26 TA resulted in a 20...

journal_title：International journal of cancer

authors： Fukushima M,Colmerauer ME,Nayak SK,Koziol JA,Pilch YH

更新日期：1982-01-15 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

journal_title：International journal of cancer

authors： Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

更新日期：2013-09-15 00:00:00

abstract：:Human mammary tumours which are histologically well differentiated are more likely to synthesize receptors for estrogen (ER) and progesterone (PR) and to respond to systemic endocrine therapy. The aim of this study was to explore the relationship between differentiation, receptors and endocrine responsiveness in more ...

journal_title：International journal of cancer

authors： Baildam AD,Howell A,Barnes DM,Redford J,Healy K,Swindell R,Sellwood RA

更新日期：1988-08-15 00:00:00

abstract：:To investigate the association of childhood ALL and SES, we collected data on 507 children aged 0-14 years diagnosed with ALL between 1997 and 2002 from the population-based Cancer Registry of São Paulo, Brazil, covering 96 districts. Each child was assigned to an SES category based on the district of residence at dia...

journal_title：International journal of cancer

authors： Ribeiro KB,Buffler PA,Metayer C

更新日期：2008-10-15 00:00:00

abstract：:The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

journal_title：International journal of cancer

authors： Lee GH,Sakai R,Nagao M,Kitagawa T

更新日期：1991-01-02 00:00:00

abstract：:Heat shock protein (HSP) gp96/grp94 contains a signal peptide at the amino terminus and a -KDEL sequence at the carboxy terminus and is a major component of the lumen of the mammalian endoplasmic reticulum (ER). We show, by a number of immunolocalization methods using light and electron microscopy, that a significant ...

journal_title：International journal of cancer

authors： Altmeyer A,Maki RG,Feldweg AM,Heike M,Protopopov VP,Masur SK,Srivastava PK

更新日期：1996-08-22 00:00:00

abstract：:Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...

journal_title：International journal of cancer

authors： Fahim Golestaneh A,Lecker LSM,Schlegel J,Nowrouzi A,Schwager C,Meister S,Weichert W,Debus J,Abdollahi A

更新日期：2019-06-01 00:00:00

abstract：:Targeted approaches have revealed frequent epigenetic alterations in ovarian cancer, but the scope and relation of these changes to histologic subtype of disease is unclear. Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 non-CCC and four corresponding normal cell lines were generated...

journal_title：International journal of cancer

authors： Yamaguchi K,Huang Z,Matsumura N,Mandai M,Okamoto T,Baba T,Konishi I,Berchuck A,Murphy SK

更新日期：2014-08-01 00:00:00

abstract：:As a part of an assessment of the potential use of retinoids in preventive and adjuvant treatment of HNSCC, we examined the effects of beta-all-trans retinoic acid (RA) on the growth and cell-surface glycoconjugates of 2 HNSCC cell lines. These lines, designated 1483 and 183A, were established from an untreated patien...

journal_title：International journal of cancer

authors： Lotan R,Sacks PG,Lotan D,Hong WK

更新日期：1987-08-15 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyz...

journal_title：International journal of cancer

authors： Hegi ME,zur Hausen A,Rüedi D,Malin G,Kleihues P

更新日期：1997-09-26 00:00:00

abstract：:The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...

journal_title：International journal of cancer

authors： Wu HL,Hsu CY,Liu WH,Yung BY

更新日期：1999-06-11 00:00:00

abstract：:Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...

journal_title：International journal of cancer

authors： Koutros S,Decker KL,Baris D,Pardo LA,Johnson A,Hosain GMM,Rothman N,Karagas MR,Schwenn MR,Silverman DT

更新日期：2021-01-27 00:00:00

abstract：:Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

journal_title：International journal of cancer

authors： Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

更新日期：2007-08-01 00:00:00

abstract：:Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-b...

journal_title：International journal of cancer

authors： Simard JF,Baecklund F,Chang ET,Baecklund E,Hjalgrim H,-Olov Adami H,Glimelius B,Smedby KE

更新日期：2013-06-01 00:00:00

abstract：:Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

journal_title：International journal of cancer

authors： Copeland BT,Bowman MJ,Boucheix C,Ashman LK

更新日期：2013-10-15 00:00:00

abstract：:The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...

journal_title：International journal of cancer

authors： Zeng J,Müller-Berghaus J,Nguyen XD,Klüter H,Schönhaber H,Song M,Schwinn N,Schadendorf D,Goerdt S,Eichmüller S,Dippel E

更新日期：2006-11-15 00:00:00

abstract：:The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

journal_title：International journal of cancer

authors： Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

更新日期：2018-08-01 00:00:00