Abstract:
:To investigate the association of childhood ALL and SES, we collected data on 507 children aged 0-14 years diagnosed with ALL between 1997 and 2002 from the population-based Cancer Registry of São Paulo, Brazil, covering 96 districts. Each child was assigned to an SES category based on the district of residence at diagnosis. Four SES categories were created from high to low, based on the Social Exclusion Index (SEI) that includes the following indicators: poverty, employment, inequality, education and violence. Using Census data, cases were also classified into quintiles according to the percentage of households with more than 7 persons. Age-specific and age-standardized incidence rates were calculated using the 1960 world standard population. Age-adjusted incidence rate was 3.68/100,000 for males and 2.87/100,000 for females. Children living in areas with lowest SES presented a significant lower risk of ALL compared with those living in the wealthiest districts (Rate Ratio [RR] = 0.34; 95% Confidence Interval [CI] = 0.28-0.44). Lower incidence rates of childhood ALL were also found in areas with high percentages of households with more than 7 persons (>or=5.7%) compared with areas where there were journal_name journal_title authors doi subject pub_date pages issue eissn issn journal_volume pub_type
abstract::Primary mediastinal B-cell lymphoma is a locally highly aggressive but poorly disseminating tumor composed of medium sized or large cells most probably of thymic medullary origin. It has a mature B-cell phenotype, typically lacks immunoglobulin expression and has variable defects in expression of HLA-molecules. We pre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1211
更新日期:2001-05-01 00:00:00
abstract::The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230318
更新日期:1979-03-15 00:00:00
abstract::Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30496
更新日期:2017-02-15 00:00:00
abstract::We conducted a population-based case-control study of 1,447 incident rectal cancer cases and 3,106 population controls aged 20-76 years to assess the effect of recreational physical activity, energy intake and obesity on rectal cancer risk in 7 of 10 Canadian provinces in 1994-97. After adjustment for the effect of va...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11159
更新日期:2003-07-20 00:00:00
abstract::Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32064
更新日期:2019-06-15 00:00:00
abstract::Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29443
更新日期:2016-01-01 00:00:00
abstract::Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29681
更新日期:2016-01-01 00:00:00
abstract::The levels of tumour-specific antigen, antibody and specific immune complexes in the sera of rats bearing lung nodules of a chemically induced rat hepatoma, produced by intravenous inoculation of viable tumour cells, have been examined and compared with the levels of serum factors in animals actively immunized by intr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170214
更新日期:1976-02-15 00:00:00
abstract::Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27944
更新日期:2013-06-01 00:00:00
abstract::Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31250
更新日期:2018-06-01 00:00:00
abstract::Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22847
更新日期:2007-10-01 00:00:00
abstract::In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31524
更新日期:2018-09-15 00:00:00
abstract::Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26120
更新日期:2011-10-01 00:00:00
abstract::Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990505)81:3<443::aid-ijc
更新日期:1999-05-05 00:00:00
abstract::The relationship between the biomarker of vitamin D status, 25(OH)D, and the risk for colorectal neoplasia is suggestive but equivocal. Questions remain regarding whether there are differential associations between 25(OH)D and colorectal adenoma by gender, colorectal subsite or features of baseline and recurrent adeno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28316
更新日期:2013-12-15 00:00:00
abstract::Clinical features, 8 histological variables, 7 nuclear morphometric variables, 2 mitotic indices, oestrogen-receptor (ER) and progesterone-receptor content (PR), DNA ploidy and S-phase fraction (SPF) were entered in a Cox's model to assess their independent predictive value in 216 breast-cancer patients followed up fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510409
更新日期:1992-06-19 00:00:00
abstract::Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32145
更新日期:2019-09-01 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.22281
更新日期:2007-03-01 00:00:00
abstract::Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24758
更新日期:2010-01-01 00:00:00
abstract::We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemoth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29017
更新日期:2015-02-01 00:00:00
abstract::Inflammatory bowel disease (IBD) patients may bear an increased neuroendocrine tumor (NET) risk. These tumors are mostly reported as coincidental findings during surgery. We aimed to determine the prevalence of colonic NET in a Dutch nationwide IBD cohort and calculate the prevalence rate ratios (PRR) compared with th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30096
更新日期:2016-08-01 00:00:00
abstract::Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.21768
更新日期:2006-06-15 00:00:00
abstract::A segment of 712 bases coding for part of the human stearoyl-CoA desaturase gene was made by polymerase chain reaction (PCR) using primers based on published rat cDNA sequences. The human PCR product was confirmed by DNA sequencing. It was next cloned into a vector from which anti-sense, highly radioactive RNA transcr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570310
更新日期:1994-05-01 00:00:00
abstract::Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22897
更新日期:2007-11-01 00:00:00
abstract::Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30037
更新日期:2016-06-15 00:00:00
abstract::To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups-women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non-cervical pre-invasive anogenital disease. All CIN3 cases diagnosed in 1989-2015 in Scotland were extracted from...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32126
更新日期:2019-07-15 00:00:00
abstract::A reanalysis of the Women's Health Initiative (WHI) randomized clinical trial found a significant interaction between supplementation with vitamin D/calcium and estrogen therapy and the risk of colorectal cancer risk, with reduced risks from supplementation limited to the placebo arms of the estrogen trials. To explor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24903
更新日期:2010-04-15 00:00:00
abstract::Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32090
更新日期:2019-09-15 00:00:00
abstract::Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1475
更新日期:2001-11-01 00:00:00