DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer.

abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

journal_title：International journal of cancer

authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

更新日期：2001-05-15 00:00:00

abstract：:Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies in developing and rural countries. We report the association of cooking conditions, fuel use, oil use, and risk of lung cancer in a developed urban population in a prospective cohort of women in...

journal_title：International journal of cancer

authors： Kim C,Gao YT,Xiang YB,Barone-Adesi F,Zhang Y,Hosgood HD,Ma S,Shu XO,Ji BT,Chow WH,Seow WJ,Bassig B,Cai Q,Zheng W,Rothman N,Lan Q

更新日期：2015-02-01 00:00:00

abstract：:Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...

journal_title：International journal of cancer

authors： Lanoy E,Spano JP,Bonnet F,Guiguet M,Boué F,Cadranel J,Carcelain G,Couderc LJ,Frange P,Girard PM,Oksenhendler E,Poizot-Martin I,Semaille C,Agut H,Katlama C,Costagliola D,ONCOVIH study group.

更新日期：2011-07-15 00:00:00

abstract：:A segment of 712 bases coding for part of the human stearoyl-CoA desaturase gene was made by polymerase chain reaction (PCR) using primers based on published rat cDNA sequences. The human PCR product was confirmed by DNA sequencing. It was next cloned into a vector from which anti-sense, highly radioactive RNA transcr...

journal_title：International journal of cancer

authors： Li J,Ding SF,Habib NA,Fermor BF,Wood CB,Gilmour RS

更新日期：1994-05-01 00:00:00

abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

journal_title：International journal of cancer

authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

更新日期：2014-03-15 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...

journal_title：International journal of cancer

authors： Watza D,Lusk CM,Dyson G,Purrington KS,Wenzlaff AS,Neslund-Dudas C,Soubani AO,Gadgeel SM,Schwartz AG

更新日期：2020-08-01 00:00:00

abstract：:Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...

journal_title：International journal of cancer

authors： Murto MO,Artama M,Pukkala E,Visvanathan K,Murtola TJ

更新日期：2018-06-01 00:00:00

abstract：:E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...

journal_title：International journal of cancer

authors： Fricke E,Keller G,Becker I,Rosivatz E,Schott C,Plaschke S,Rudelius M,Hermannstädter C,Busch R,Höfler H,Becker KF,Luber B

更新日期：2003-03-10 00:00:00

abstract：:Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratif...

journal_title：International journal of cancer

authors： Gustafson LW,Booth BB,Kahlert J,Ørtoft G,Mejlgaard E,Clarke MA,Wentzensen N,Rositch AF,Hammer A

更新日期：2021-02-01 00:00:00

abstract：:Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...

journal_title：International journal of cancer

authors： Fiegl H,Windbichler G,Mueller-Holzner E,Goebel G,Lechner M,Jacobs IJ,Widschwendter M

更新日期：2008-08-01 00:00:00

abstract：:Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

journal_title：International journal of cancer

authors： Lerman MI,Hegamyer GA,Colburn NH

更新日期：1986-02-15 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...

journal_title：International journal of cancer

authors： Furuta H,Osawa K,Shin M,Ishikawa A,Matsuo K,Khan M,Aoki K,Ohya K,Okamoto M,Tominaga K,Takahashi T,Nakanishi O,Jimi E

更新日期：2012-09-01 00:00:00

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:Tumor angiogenesis plays a critical role in colorectal cancer progression. Recent randomized clinical trials have revealed the additive effect of bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, to conventional chemotherapy in the improved survival of patients with meta...

journal_title：International journal of cancer

authors： Miyazaki S,Kikuchi H,Iino I,Uehara T,Setoguchi T,Fujita T,Hiramatsu Y,Ohta M,Kamiya K,Kitagawa K,Kitagawa M,Baba S,Konno H

更新日期：2014-07-15 00:00:00

abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...

journal_title：International journal of cancer

authors： Whitehall VL,Rickman C,Bond CE,Ramsnes I,Greco SA,Umapathy A,McKeone D,Faleiro RJ,Buttenshaw RL,Worthley DL,Nayler S,Zhao ZZ,Montgomery GW,Mallitt KA,Jass JR,Matsubara N,Notohara K,Ishii T,Leggett BA

更新日期：2012-08-15 00:00:00

abstract：:Colorectal (CRC) and gastric cancers (GC), the most common gastrointestinal malignancies, have been known to develop occasionally in a same patient. Previous studies have focused on the etiology of patients with multiple primary gastric and colorectal cancer (MPGCC); however, the carcinogenic process of MPGCC remains ...

journal_title：International journal of cancer

authors： Ohtani H,Yashiro M,Onoda N,Nishioka N,Kato Y,Yamamoto S,Fukushima S,Hirakawa-Ys Chung K

更新日期：2000-06-01 00:00:00

abstract：:In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...

journal_title：International journal of cancer

authors： Ureta-Vidal A,Angelin-Duclos C,Tortevoye P,Murphy E,Lepère JF,Buigues RP,Jolly N,Joubert M,Carles G,Pouliquen JF,de Thé G,Moreau JP,Gessain A

更新日期：1999-09-09 00:00:00

abstract：:The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

journal_title：International journal of cancer

authors： Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

更新日期：2015-02-01 00:00:00

abstract：:Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire...

journal_title：International journal of cancer

authors： Lin Y,Kikuchi S,Tamakoshi K,Wakai K,Kondo T,Niwa Y,Yatsuya H,Nishio K,Suzuki S,Tokudome S,Yamamoto A,Toyoshima H,Tamakoshi A

更新日期：2005-09-20 00:00:00

abstract：:While platelet-derived growth factor, PDGF, is not regularly expressed in mesenchymal tissues, PDGF B mRNA is often found in tumors derived from these tissues. PDGF B protein is also present, but the protein levels in individual tumors do not appear to correlate well with those of the mRNA. PDGF B is homologous to the...

journal_title：International journal of cancer

authors： Heller S,Scheibenpflug L,Westermark B,Nistér M

更新日期：2000-01-15 00:00:00

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low-fat milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Eighty 6-week-old female Sprague-Dawley rats received a single oral dose of 5 mg DMBA. Twenty-four hours l...

journal_title：International journal of cancer

authors： Qin LQ,Xu JY,Wang PY,Ganmaa D,Li J,Wang J,Kaneko T,Hoshi K,Shirai T,Sato A

更新日期：2004-07-01 00:00:00

abstract：:Sequence diversity over 2600 nucleotides of the upstream regulatory region (URR) and the E6 and E2/E4 genes of 34 human papillomavirus (HPV)16 cervical cancer isolates from Australia and New Caledonia was investigated. One 81 base duplication, 41 single base substitutions and 1 single base insertion were identified in...

journal_title：International journal of cancer

authors： Watts KJ,Thompson CH,Cossart YE,Rose BR

更新日期：2002-02-20 00:00:00

abstract：:A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...

journal_title：International journal of cancer

authors： Gao YT,McLaughlin JK,Blot WJ,Ji BT,Benichou J,Dai Q,Fraumeni JF Jr

更新日期：1994-07-15 00:00:00

abstract：:A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...

journal_title：International journal of cancer

authors： Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NE

更新日期：1985-05-15 00:00:00

abstract：:A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...

journal_title：International journal of cancer

authors： Reubi JC,Waser B,van Hagen M,Lamberts SW,Krenning EP,Gebbers JO,Laissue JA

更新日期：1992-04-01 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (...

journal_title：International journal of cancer

authors： Tressler RJ,Garvin LJ,Slate DL

更新日期：1994-05-15 00:00:00

abstract：:In mice as well as humans, cytotoxic T lymphocytes (CTL) specific for wild-type-sequence (wt) p53 peptides have been shown to react against a wide range of tumors, but not normal cells. As such, they are attractive candidates for developing broadly applicable cancer vaccines. Of particular interest is the potential of...

journal_title：International journal of cancer

authors： Cicinnati VR,Dworacki G,Albers A,Beckebaum S,Tüting T,Kaczmarek E,DeLeo AB

更新日期：2005-03-01 00:00:00

abstract：:We report the inhibitory effect of 4-methylesculetin (ME), a 4-methylumbelliferone derivative, on hyaluronan (HA) synthesis by pancreatic cancer cells, and its resulting anticancer action. First, HA in cell culture was analyzed using competitive inhibition with hyaluronic acid-binding protein (HABP) to study HA synthe...

journal_title：International journal of cancer

authors： Hajime M,Shuichi Y,Makoto N,Masanori Y,Ikuko K,Atsushi K,Mutsuo S,Keiichi T

更新日期：2007-06-15 00:00:00