Abstract:
:Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (MM). The growth of all the cell lines tested was inhibited by MPA in vitro, with EC50 values ranging from less than 0.1 microM to 3.9 microM. Mice were monitored for s.c. tumor outgrowth in the case of human tumor xenograft models or survival time for the murine experimental metastasis model. Treatment with MM p.o. was started 24 hr after tumor challenge or after tumors became palpable. Treatment of athymic nude mice bearing A3.01 (T-lymphoblast), Molt-4 (T-cell leukemia), CaPan-2 (pancreatic adenocarcinoma), CaLu-3 (non-small-cell lung adenocarcinoma), LS174T and T84 (colon adenocarcinoma), and Daudi (B-cell lymphoma) human tumor xenografts with MM significantly inhibited s.c. tumor growth. Treatment of BALB/c mice with MM after i.v. injection of murine RAW117-H10 lymphoma cells in an experimental metastasis assay resulted in increased survival time for treated animals. No significant inhibitory effect on s.c. tumor outgrowth was seen with MM treatment of SK-Hep-1, a human hepatic endothelioma, or Hep-3B, a liver adenocarcinoma, at any of the doses tested.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tressler RJ,Garvin LJ,Slate DLdoi
10.1002/ijc.2910570421subject
Has Abstractpub_date
1994-05-15 00:00:00pages
568-73issue
4eissn
0020-7136issn
1097-0215journal_volume
57pub_type
杂志文章abstract::Our aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC), so as to provide insights for individualized adjuvant therapy. Plasma miRNA expression was investigated in three phases, involving 407 patients recrui...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30895
更新日期:2017-11-15 00:00:00
abstract::Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 9...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961115)68:4<424::AID-IJC
更新日期:1996-11-15 00:00:00
abstract::Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
abstract::Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600409
更新日期:1995-02-08 00:00:00
abstract::While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...
journal_title:International journal of cancer
pub_type: 杂志文章
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abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32014
更新日期:2019-05-01 00:00:00
abstract::MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980209)75:4<517::aid-ijc
更新日期:1998-02-09 00:00:00
abstract::We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24349
更新日期:2009-06-15 00:00:00
abstract::Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550610
更新日期:1993-12-02 00:00:00
abstract::XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10776
更新日期:2003-01-01 00:00:00
abstract::The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21396
更新日期:2006-02-01 00:00:00
abstract::Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480513
更新日期:1991-07-09 00:00:00
abstract::Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29495
更新日期:2015-09-15 00:00:00
abstract::An immunopotentiating factor associated with spleen cells of C57BL/6J mice bearing the 3LL tumor is described. Supernatants of cultured spleen cells from tumor-bearing mice (TBM) augmented the generation of both 19S and 7S antibody-producing cells, when injected with sheep erythrocytes into syngeneic C57BL/6J mice. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220416
更新日期:1978-10-15 00:00:00
abstract::The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010520)95:3<168::aid-ijc1029>3
更新日期:2001-05-20 00:00:00
abstract::Epigenome-wide association studies have established methylation patterns related to smoking, the major risk factor of lung cancer (LC), which are distinct from methylation profiles disclosed in LC patients. This study simultaneously investigated associations of smoking-associated and LC-related methylation markers wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30374
更新日期:2016-12-01 00:00:00
abstract::Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0215(19991210)83:6<852::aid-ijc
更新日期:1999-12-10 00:00:00
abstract::Protein phosphatase 2A (PP2A) consists of 3 subunits: the catalytic subunit, C, and the regulatory subunits, A and B. The A and C subunits both exist as 2 isoforms (alpha and beta) and the B subunit as multiple forms subdivided into 3 families, B, B' and B". It has been reported that the genes encoding the Aalpha and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1423
更新日期:2001-09-01 00:00:00
abstract::We investigated the therapeutic potential and molecular mechanism of adenovirus-mediated wt p53 gene therapy for drug-resistant human bladder cancers. KK47, a human bladder-cancer cell line, along with the drug-resistant sublines KK47/DDP10, KK47/DDP20 (cisplatin-resistant) and KK47/ADM (doxorubicin-resistant) were us...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1453
更新日期:2001-10-15 00:00:00
abstract::The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...
journal_title:International journal of cancer
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doi:10.1002/ijc.1352
更新日期:2001-08-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560221
更新日期:1994-01-15 00:00:00
abstract::The aim of our study was to estimate uptake of prostate-specific antigen (PSA) testing in an entire country, including time trends and geographical differences. Data from the Swedish Cancer Register on prostate cancer incidence between 1980 and 2007 and published data from the Gothenburg branch of the European randomi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25846
更新日期:2011-10-15 00:00:00
abstract::To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation and vasculari...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31567
更新日期:2018-10-01 00:00:00
abstract::Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32964
更新日期:2020-10-01 00:00:00
abstract::The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450635
更新日期:1990-06-15 00:00:00
abstract::Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29087
更新日期:2015-03-01 00:00:00
abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960503)66:3<374::AID-IJC
更新日期:1996-05-03 00:00:00
abstract::Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490619
更新日期:1991-12-02 00:00:00
abstract::The lck gene encodes a lymphocyte-specific tyrosine protein kinase, p56lck, the expression of which is almost exclusive in T-cells. The expression of lck in human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines is closely associated with interleukin-2 (IL-2) dependence for their growth. That is, IL-2-de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480526
更新日期:1991-07-09 00:00:00
abstract::Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20420
更新日期:2004-11-01 00:00:00