Drug-resistant human bladder-cancer cells are more sensitive to adenovirus-mediated wild-type p53 gene therapy compared to drug-sensitive cells.

abstract：:E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...

journal_title：International journal of cancer

authors： Fricke E,Keller G,Becker I,Rosivatz E,Schott C,Plaschke S,Rudelius M,Hermannstädter C,Busch R,Höfler H,Becker KF,Luber B

更新日期：2003-03-10 00:00:00

abstract：:The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

journal_title：International journal of cancer

authors： Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

更新日期：2000-05-20 00:00:00

abstract：:An investigation was carried out to establish whether the reduction in catalase, glutathione peroxidase and superoxide dismutase activity, normally observed in liver tumours, is an early event and therefore of pathogenetic importance, or whether it is a late occurrence. Experiments performed on dimethylnitrosamine-tre...

journal_title：International journal of cancer

authors： Liotti FS,Menghini AR,Guerrieri P,Mariucci G,Locci P,Bruschelli G

更新日期：1988-11-15 00:00:00

abstract：:The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 a...

journal_title：International journal of cancer

authors： Law LW

更新日期：1980-02-15 00:00:00

abstract：:Molecular characterization has been extensively studied in serrated polyps but very little is known in serrated adenocarcinomas (SACs). We analyzed the incidence of KRAS, BRAF and PIK3CA mutations, microsatellite instability (MSI) status and loss of the DNA repair proteins MLH1, MSH2, MSH6 and MGMT in a series of 89 S...

journal_title：International journal of cancer

authors： García-Solano J,Conesa-Zamora P,Carbonell P,Trujillo-Santos J,Torres-Moreno D D,Pagán-Gómez I,Rodríguez-Braun E,Pérez-Guillermo M

更新日期：2012-10-15 00:00:00

abstract：:Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer...

journal_title：International journal of cancer

authors： Ferlay J,Colombet M,Soerjomataram I,Mathers C,Parkin DM,Piñeros M,Znaor A,Bray F

更新日期：2019-04-15 00:00:00

abstract：:Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular pla...

journal_title：International journal of cancer

authors： Dhamija S,Diederichs S

更新日期：2016-07-15 00:00:00

abstract：:The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...

journal_title：International journal of cancer

authors： Wei L,Xu Z

更新日期：2011-07-15 00:00:00

abstract：:Primary mediastinal B-cell lymphoma is a locally highly aggressive but poorly disseminating tumor composed of medium sized or large cells most probably of thymic medullary origin. It has a mature B-cell phenotype, typically lacks immunoglobulin expression and has variable defects in expression of HLA-molecules. We pre...

journal_title：International journal of cancer

authors： Möller P,Brüderlein S,Sträter J,Leithäuser F,Hasel C,Bataille F,Moldenhauer G,Pawlita M,Barth TF

更新日期：2001-05-01 00:00:00

abstract：:Although human NK cells lyse a wide spectrum of target cells, the precise target structure recognized by NK cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to NK lysis, 14 human leukemia and lymphoma cell lines were studied. A ...

journal_title：International journal of cancer

authors： Ando I,Hoon DS,Suzuki Y,Saxton RE,Golub SH,Irie RF

更新日期：1987-07-15 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...

journal_title：International journal of cancer

authors： Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

更新日期：2017-06-01 00:00:00

abstract：:During natural metastasis, cancer cells are released continuously into the bloodstream and arrested in target organs; the process is repetitive rather than a single event. In this communication, the effect of preceding on successive "pulses" of cancer cells is discussed in relation to the arrest, retention and tumor f...

journal_title：International journal of cancer

authors： Ward PM,Weiss L

更新日期：1985-10-15 00:00:00

abstract：:We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ER...

journal_title：International journal of cancer

authors： Sefrioui D,Vermeulin T,Blanchard F,Chapusot C,Beaussire L,Armengol-Debeir L,Sesboué R,Gangloff A,Hebbar M,Copin MC,Houivet E,Schwarz L,Clatot F,Tuech JJ,Bénichou J,Martin L,Bouvier AM,Sabourin JC,Sarafan-Vasseur N,F

更新日期：2017-04-01 00:00:00

abstract：:The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...

journal_title：International journal of cancer

authors： Miura S,Kim YS

更新日期：1986-08-15 00:00:00

abstract：:Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C-terminus of the AIB1 protein (amplified in breast cancer 1, a steroid receptor ...

journal_title：International journal of cancer

authors： Hughes DJ,Ginolhac SM,Coupier I,Barjhoux L,Gaborieau V,Bressac-de-Paillerets B,Chompret A,Bignon YJ,Uhrhammer N,Lasset C,Giraud S,Sobol H,Hardouin A,Berthet P,Peyrat JP,Fournier J,Nogues C,Lidereau R,Muller D,Fricke

更新日期：2005-11-01 00:00:00

abstract：:We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...

journal_title：International journal of cancer

authors： Hori S,Wadhwa K,Pisupati V,Zecchini V,Ramos-Montoya A,Warren AY,Neal DE,Gnanapragasam VJ

更新日期：2017-04-15 00:00:00

abstract：:Fibroblast-like cells (F-cells) and epithelial-like (E-cells) derived from cultures of rabbit VX-2 carcinoma released collagenase in both active and latent forms in serum-free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F-cells to release the enzyme, however, c...

journal_title：International journal of cancer

authors： Dabbous MK,El-Torky M,Haney L,Brinkley SB,Sobhy N

更新日期：1983-03-15 00:00:00

abstract：:The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...

journal_title：International journal of cancer

authors： Kramárová E,Stiller CA

更新日期：1996-12-11 00:00:00

abstract：:For breast cancer, many prognostic markers that initially appeared promising have failed to maintain their clinical predictive value. Few reports have analyzed the consistency over time of biological and clinical information provided by biomarkers. Tumour cell proliferation has acquired relevance as an indicator of pr...

journal_title：International journal of cancer

authors： Silvestrini R,Daidone MG,Luisi A,Mastore M,Leutner M,Salvadori B

更新日期：1997-02-20 00:00:00

abstract：:Growth of a highly-deviated ascites hepatoma (Yoshida AH-130) in rats caused initial hyperplastic enlargement of the liver, followed by progressive reduction to a size lower than that seen in controls. The time-course of this biphasic change in liver weight roughly corresponded to the exponential and stationary phases...

journal_title：International journal of cancer

authors： Tessitore L,Valente G,Bonelli G,Costelli P,Baccino FM

更新日期：1989-10-15 00:00:00

abstract：:Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...

journal_title：International journal of cancer

authors： De Pietri S,Ingham AC,Frandsen TL,Rathe M,Krych L,Castro-Mejía JL,Nielsen DS,Nersting J,Wehner PS,Schmiegelow K,Hasle H,Pamp SJ,Müller K

更新日期：2020-10-01 00:00:00

abstract：:Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

journal_title：International journal of cancer

authors： Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

更新日期：2009-12-01 00:00:00

abstract：:Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...

journal_title：International journal of cancer

authors： Hwang JH,Yoon J,Cho YH,Cha PH,Park JC,Choi KY

更新日期：2020-05-15 00:00:00

abstract：:In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...

journal_title：International journal of cancer

authors： Reduzzi C,Vismara M,Silvestri M,Celio L,Niger M,Peverelli G,De Braud F,Daidone MG,Cappelletti V

更新日期：2020-06-15 00:00:00

abstract：:In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...

journal_title：International journal of cancer

authors： Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM

更新日期：2020-12-01 00:00:00

abstract：:To further examine the association between oral hygiene and esophageal squamous cell carcinoma (ESCC) risk and the effect modification of other exposures, we conducted a population-based case-control study between 2010 and 2012 in Taixing, China, a high-risk area for ESCC. Cases were primarily recruited from endoscopy...

journal_title：International journal of cancer

authors： Chen X,Yuan Z,Lu M,Zhang Y,Jin L,Ye W

更新日期：2017-02-01 00:00:00

abstract：:The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromo...

journal_title：International journal of cancer

authors： Bello MJ,Leone PE,Vaquero J,de Campos JM,Kusak ME,Sarasa JL,Pestaña A,Rey JA

更新日期：1995-06-22 00:00:00

abstract：:Brain metastases are the most prevalent intracranial malignancy. Patient outcome is poor and treatment options are limited. Hence, new avenues must be explored to identify potential therapeutic targets. Inflammation is a known critical component of cancer progression. Intratumoral inflammation drives progression and l...

journal_title：International journal of cancer

authors： Sikpa D,Whittingstall L,Fouquet JP,Radulska A,Tremblay L,Lebel R,Paquette B,Lepage M

更新日期：2020-07-01 00:00:00

abstract：:The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

journal_title：International journal of cancer

authors： Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

更新日期：2000-06-15 00:00:00

abstract：:Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...

journal_title：International journal of cancer

authors： Jiang X,Bernstein L,Tseng CC,Wu AH

更新日期：2012-09-15 00:00:00