Drug-resistant human bladder-cancer cells are more sensitive to adenovirus-mediated wild-type p53 gene therapy compared to drug-sensitive cells.

abstract：:Malignant tumors are generally characterized by extensive local tissue invasion and destruction of ECM which may be due to increased constitutive expression and activity of secreted proteases. Moreover, a large number of diverse protease activities may be constitutively over-expressed in a simultaneous or co-ordinated...

journal_title：International journal of cancer

authors： Korczak B,Kerbel RS,Dennis J

更新日期：1991-06-19 00:00:00

abstract：:A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

journal_title：International journal of cancer

authors： Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

更新日期：1978-03-15 00:00:00

abstract：:Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or c...

journal_title：International journal of cancer

authors： Dimou NL,Papadimitriou N,Mariosa D,Johansson M,Brennan P,Peters U,Chanock SJ,Purdue M,Bishop DT,Gago-Dominquez M,Giles GG,Moreno V,Platz EA,Tangen CM,Wolk A,Zheng W,Wu X,Campbell PT,Giovannucci E,Lin Y,CCFR, Endom

更新日期：2020-10-10 00:00:00

abstract：:Metastatic tumor formation via vessel route begins with cancer cell extravasation from vessel lumen, migration into the connective tissue surrounding vessels, and invasion into target organ parenchyma. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been recognized to play an i...

journal_title：International journal of cancer

authors： Aokage K,Ishii G,Ohtaki Y,Yamaguchi Y,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A

更新日期：2011-04-01 00:00:00

abstract：:A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...

journal_title：International journal of cancer

authors： Cordon-Cardo C,Lloyd KO,Sakamoto J,McGroarty ME,Old LJ,Melamed MR

更新日期：1986-05-15 00:00:00

abstract：:The effect of blockade of NF-kappaB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-kappaB activity, were transfected with a mutated IkappaBalpha (IkappaBalphaM)....

journal_title：International journal of cancer

authors： Xiong HQ,Abbruzzese JL,Lin E,Wang L,Zheng L,Xie K

更新日期：2004-01-10 00:00:00

abstract：:Breast cancer screening is known to reduce breast cancer mortality. A high breast density may affect this reduction. We assessed the effect of screening on breast cancer mortality in women with dense and fatty breasts separately. Analyses were performed within the Nijmegen (Dutch) screening programme (1975-2008), whic...

journal_title：International journal of cancer

authors： van der Waal D,Ripping TM,Verbeek AL,Broeders MJ

更新日期：2017-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...

journal_title：International journal of cancer

authors： Ruan Q,Wang H,Burke LJ,Bridle KR,Li X,Zhao CX,Crawford DHG,Roberts MS,Liang X

更新日期：2020-09-15 00:00:00

abstract：:Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine ...

journal_title：International journal of cancer

authors： Koshkina NV,Kleinerman ES

更新日期：2005-09-01 00:00:00

abstract：:Cancer incidence rates and patterns are reported for a rural population, living in the Eastern Cape Province of South Africa for the period 1998-2002. The population-based cancer registry has operated for 20 years, using both active and passive methods for case finding, through collaborations with 19 health facilities...

journal_title：International journal of cancer

authors： Somdyala NI,Bradshaw D,Gelderblom WC,Parkin DM

更新日期：2010-11-15 00:00:00

abstract：:People living with lymphohematopoietic neoplasms (LHNs) are known to have increased risks of second cancer; however, the incidence of second cancers after LHNs has not been studied extensively in Australia. The Australian Cancer Database was used to analyze site-specific risk of second primary cancer after LHNs in 127...

journal_title：International journal of cancer

authors： Royle JS,Baade P,Joske D,Fritschi L

更新日期：2011-08-15 00:00:00

abstract：:Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of patients respond poorly to PTX or relapse after its use, a greater und...

journal_title：International journal of cancer

authors： Lasham A,Mehta SY,Fitzgerald SJ,Woolley AG,Hearn JI,Hurley DG,Ruza I,Algie M,Shelling AN,Braithwaite AW,Print CG

更新日期：2016-09-01 00:00:00

abstract：:The effects of concomitant administration of bombesin and of the diuretic drug amiloride on the development of large and small intestinal tumors induced by azoxymethane (AOM), the incidence of their metastasis to the peritoneum and the labeling index of intestinal adenocarcinomas were investigated in inbred Wistar rat...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Uehara H,Nakaizumi A

更新日期：1995-11-27 00:00:00

abstract：:Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...

journal_title：International journal of cancer

authors： Deauvieau F,Ollion V,Doffin AC,Achard C,Fonteneau JF,Verronese E,Durand I,Ghittoni R,Marvel J,Dezutter-Dambuyant C,Walzer T,Vie H,Perrot I,Goutagny N,Caux C,Valladeau-Guilemond J

更新日期：2015-03-01 00:00:00

abstract：:Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...

journal_title：International journal of cancer

authors： Bertino P,Panigada M,Soprana E,Bianchi V,Bertilaccio S,Sanvito F,Rose AH,Yang H,Gaudino G,Hoffmann PR,Siccardi A,Carbone M

更新日期：2013-08-01 00:00:00

abstract：:A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen c...

journal_title：International journal of cancer

authors： Levingston CA,Young MR

更新日期：2017-04-01 00:00:00

abstract：:Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...

journal_title：International journal of cancer

authors： Klaeboe L,Blaasaas KG,Haldorsen T,Tynes T

更新日期：2005-05-20 00:00:00

abstract：:In our study, we aimed to investigate the expression of N-cadherin and E-cadherin and their dependency on epithelial-mesenchymal transition regulators SNAI1, SIP1 and TWIST in human colon cancer. Expression of E-cadherin and N-cadherin was examined by immunohistochemistry in 80 colon carcinomas by using paraffin embed...

journal_title：International journal of cancer

authors： Rosivatz E,Becker I,Bamba M,Schott C,Diebold J,Mayr D,Höfler H,Becker KF

更新日期：2004-09-20 00:00:00

abstract：:We report on pigmentary characteristics, sun sensitivity and some other possible risk factors for non-Hodgkin lymphoma (NHL) in people 20-74 years of age. A statewide case-control study was conducted in New South Wales, Australia, with population-based sampling of cases (n = 704) and controls (n = 694). Risk of NHL wa...

journal_title：International journal of cancer

authors： Hughes AM,Armstrong BK,Vajdic CM,Turner J,Grulich A,Fritschi L,Milliken S,Kaldor J,Benke G,Kricker A

更新日期：2004-06-20 00:00:00

abstract：:Occupational exposures were assessed in a case-control study on testicular cancer using self-administered questionnaires. In total, answers were obtained for 148 (91%) cases and 315 (87%) controls. Of the cases, 101 had seminoma and 47 had embryonal testicular cancer. An increased odds ratio (OR) was found for exposur...

journal_title：International journal of cancer

authors： Hardell L,Ohlson CG,Fredrikson M

更新日期：1997-12-10 00:00:00

abstract：:Gliomas are aggressive tumors of the central nervous system originating from proliferating neural cells. Regulators of neural stem or progenitor cells biology may thus influence aspects of brain tumorigenesis, such as the maintenance of tumor-propagating potential. We investigated the role of Pax6, a neurogenic transc...

journal_title：International journal of cancer

authors： Appolloni I,Calzolari F,Barilari M,Terrile M,Daga A,Malatesta P

更新日期：2012-10-01 00:00:00

abstract：:We observed previously that two carbohydrate epitopes, extended type 1 chain Le(a)-Le(a) and Le(b)-Le(a), are expressed strongly in human gastric or colorectal cancer and cell lines derived therefrom, but their expression in human normal colorectal cells is highly limited. A monoclonal antibody, termed GNX-8, was esta...

journal_title：International journal of cancer

authors： Yang MC,Hsu FL,Handa K,Hakomori S,Lee MH,Liu LY,Chang SY,Ting J,Wen JY,Ishida I,Chang TH

更新日期：2009-12-21 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and angiogenesis in colorectal cancer. We examined a possible involvement of store-operated calcium (SOC) entry in human colon carcinoma cells (HRT-18), which require calcium for proliferation. Acetyl-salicylic-acid (ASA), mefenamic acid (MEF) and su...

journal_title：International journal of cancer

authors： Weiss H,Amberger A,Widschwendter M,Margreiter R,Ofner D,Dietl P

更新日期：2001-06-15 00:00:00

abstract：:Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...

journal_title：International journal of cancer

authors： Ellinger J,Kahl P,Mertens C,Rogenhofer S,Hauser S,Hartmann W,Bastian PJ,Büttner R,Müller SC,von Ruecker A

更新日期：2010-11-15 00:00:00

abstract：:To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...

journal_title：International journal of cancer

authors： Parmiani G,Sensi ML,Carbone G,Colombo M,Pierotti M,Ballinari D,Hilgers J,Hilkens J

更新日期：1982-03-15 00:00:00

abstract：:The role of natural immune defense in the control of metastatic spread of tumor cells was evaluated by adapting an s.c.-grown, antigenic, but non-immunogenic rat fibrosarcoma (Bsp6S) to ascitic growth (BSp6A) in the strain of origin (BDX), where peritoneal cells display a high level of NK and macrophage activity. Para...

journal_title：International journal of cancer

authors： Zöller M

更新日期：1986-01-15 00:00:00

abstract：:The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients. The 600-base pS2 mRNA was found in all of the 47 non-neoplastic samples at varying levels: in the histologically normal group we observed a Poisson-type distribution, whereas 79% of ...

journal_title：International journal of cancer

authors： Luqmani Y,Bennett C,Paterson I,Corbishley CM,Rio MC,Chambon P,Ryall G

更新日期：1989-11-15 00:00:00

abstract：:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

journal_title：International journal of cancer

authors： Werkmeister J,Phillips G,McCarthy W,Hersey P

更新日期：1981-07-15 00:00:00

abstract：:Immunostimulatory DNA containing unmethylated cytosine-guanine (CpG) motifs have been successfully used as adjuvants to enhance the immunity of vaccines designed to trigger antitumor T-cell responses. We examined the effect of a CpG oligodeoxynucleotide (CpG ODN) for its ability to potentiate the activity of tumor ant...

journal_title：International journal of cancer

authors： Saha A,Bhattacharya-Chatterjee M,Foon KA,Celis E,Chatterjee SK

更新日期：2009-02-15 00:00:00

abstract：:Endometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenoc...

journal_title：International journal of cancer

authors： Hiroki E,Suzuki F,Akahira J,Nagase S,Ito K,Sugawara J,Miki Y,Suzuki T,Sasano H,Yaegashi N

更新日期：2012-08-15 00:00:00