Abstract:
:The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 and CII-7, TATA activity was lost during early in vivo passages. This activity was reestablished invivo from the in vitro-passaged lines in CI-I and CII-7 and these sarcomas along with CI-3, CI-4 and CII-10 maintained a stable TATA phenotype throughout the 50 transplant passages; TATA was lost permanently, however, in CII-5. These results indicate a dimorphic nature of early-passage neoplasms. No cross-reacting antigens were detected among these sarcomas, including also Meth A, a sarcoma well characterized as to its membrane antigens; nor was any evidence obtained for the existence of alien (inappropriate) H-2 antigens employing tumor rejection assays in F1 hybrids of BALB/c with strains bearing several haplotypes and also with studies of H-2 serology. In three sarcomas, some evidence was obtained for the existence of alloantigens of the non-H-2 type since it was found that (BALB/c X DBA/2)F1 hybrids could not be immunized by respective sarcomas. These findings suggest the existence on these sarcomas of a tumor antigen that is expressed normally in DBA/2 mice, although no definitive evidence has been obtained. Assays for MuLV, for the viral structural proteins gp70 and p30 and for reverse transcriptase showed that three sarcomas were positive and three others, as well as Meth A, were negative. MuLV and its antigens had no influence on tumor rejection activity nor could the cross-reactivity observed in the radioisotopic footpad assay (IFP) be related to MuLV.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Law LWdoi
10.1002/ijc.2910250213subject
Has Abstractpub_date
1980-02-15 00:00:00pages
251-9issue
2eissn
0020-7136issn
1097-0215journal_volume
25pub_type
杂志文章abstract::A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10454
更新日期:2002-07-20 00:00:00
abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26148
更新日期:2012-04-01 00:00:00
abstract::The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190407
更新日期:1977-04-15 00:00:00
abstract::Mortality rates for cancer of all sites combined and for 12 selected sites or site groups in Estonia from 1965 to 1989 were studied to assess overall progress in controlling cancer. Between 1965-1969 and 1985-1989, age-standardized mortality (world population) increased by 12.0% among males and decreased by 5.1% among...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530608
更新日期:1993-04-01 00:00:00
abstract::Seventy to 40% of K-RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti-EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF-1 system, altered activation colorectal cancer cells may escape anti-EGFR mediated cell death. The inter...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25193
更新日期:2010-10-15 00:00:00
abstract::Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21786
更新日期:2006-07-01 00:00:00
abstract::Cancer chemotherapy with platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We evaluated the antinociceptive effects of the alpha-2 adrenoceptor agonist, clonidine on oxaliplatin-induced neuropathic pain. Specifically, we determined if (i)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29980
更新日期:2016-05-15 00:00:00
abstract::Loss of heterozygosity (LOH) is an important event of tumorigenesis. In gastric cancer, we found a novel region of LOH in chromosome 9q having about 800 kb deletions at 9q31.1. The microsatellite marker D9S938 in that region exhibiting the highest LOH frequency, 56.5%. In addition, the LOH at 9q31.1 did not show any r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11674
更新日期:2004-03-01 00:00:00
abstract::Actin, a highly conserved protein comprising cell stress fibers and other cellular structures, is found in both the cytoplasm and nucleus of cells and responds to both epigenetic signals and altered gene expression occurring during tumorigenesis. We have previously shown that changes in the cytoplasmic F- and G-actin ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970207)70:4<423::aid-ijc
更新日期:1997-02-07 00:00:00
abstract::Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27417
更新日期:2012-10-01 00:00:00
abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280504
更新日期:1981-11-15 00:00:00
abstract::Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these experiments. Only a small propor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160205
更新日期:1975-08-15 00:00:00
abstract::Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29967
更新日期:2016-05-01 00:00:00
abstract::Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31058
更新日期:2018-01-15 00:00:00
abstract::Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28934
更新日期:2014-12-15 00:00:00
abstract::IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25140
更新日期:2010-09-01 00:00:00
abstract::By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11587
更新日期:2004-02-10 00:00:00
abstract::The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11470
更新日期:2003-12-20 00:00:00
abstract::In this prospective study, the relationship between energy and fat consumption and the risk of breast cancer was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age attended a health screening. The attendees were given a food-frequency questionnaire to be completed at home, and this was retu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630104
更新日期:1995-09-27 00:00:00
abstract::Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30017
更新日期:2016-06-15 00:00:00
abstract::The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Immunohistochemical studies have shown that this overexpression is linked to higher aggressiveness of colorectal carcinoma and to enhanced metastatic potential of melanoma cells. However, the antibodies so far developed against Nup88 have the draw...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20034
更新日期:2004-05-01 00:00:00
abstract::The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.11335
更新日期:2003-10-20 00:00:00
abstract::Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10753
更新日期:2002-12-20 00:00:00
abstract::Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32145
更新日期:2019-09-01 00:00:00
abstract::W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160305
更新日期:1975-09-15 00:00:00
abstract::Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480513
更新日期:1991-07-09 00:00:00
abstract::Myf-3 is the human homologue of the murine Myo-D1 gene involved in muscle-cell differentiation. Using Southern blot analysis, we examined methylation of Myf-3 in histologically normal colonic mucosae, adenomas and carcinomas from a large series of patients with primary colorectal cancer. Hypermethylation of this gene ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990420)84:2<109::aid-ijc
更新日期:1999-04-20 00:00:00
abstract::Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23498
更新日期:2008-07-15 00:00:00
abstract::Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24149
更新日期:2009-05-01 00:00:00
abstract::Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast 2-hybrid system of a testicular cDNA library, 17 interacting clones were isolated and all encoded Ropporin, a spermato...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22842
更新日期:2007-10-01 00:00:00