Abstract:
:The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reductions in electrophoretic mobilities were observed, compared with 12/33 in controls. Our overall results on the reductions in macrophage mobilities by lymphocyte products are in accord with the work of some other workers, but not all. In contrast to many other studies, the standard procedures used here to express the results should permit an exchange of data on an international basis and allow a more rapid, general appraisal of the MEM test.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Glaves D,Harlos JP,Weiss Ldoi
10.1002/ijc.2910190407subject
Has Abstractpub_date
1977-04-15 00:00:00pages
474-81issue
4eissn
0020-7136issn
1097-0215journal_volume
19pub_type
杂志文章abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28204
更新日期:2013-10-15 00:00:00
abstract::Treatment of human colorectal tumor cells (LS174T, HT-29, and WiDr) with analogues of cyclic AMP (cAMP) (dibutyryl-cAMP and 8-Cl-cAMP) selectively enhances the expression of carcinoembryonic antigen (CEA). Dose and temporal kinetics results revealed that 8-Cl-cAMP was approximately 100-fold more potent than dibutyryl-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480319
更新日期:1991-05-30 00:00:00
abstract::Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33362
更新日期:2021-02-15 00:00:00
abstract::Colorectal cancer is among the commonest cancers worldwide. Dietary factors have been linked to colorectal cancer risk, however, few studies have evaluated the relationship between a priori dietary patterns and colorectal cancer risk. We evaluated the effect of adherence to a Mediterranean dietary pattern, as measured...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27740
更新日期:2013-03-15 00:00:00
abstract::We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970611)71:6<978::aid-ijc
更新日期:1997-06-11 00:00:00
abstract::Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compounds by tumor cells. Influx of the anti-folate methotrexate via the r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610616
更新日期:1995-06-09 00:00:00
abstract::The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrophoretic mobility of the open and covalently closed circular forms of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19981029)78:3<346::AID-IJC
更新日期:1998-10-29 00:00:00
abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280504
更新日期:1981-11-15 00:00:00
abstract::In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10308
更新日期:2002-05-10 00:00:00
abstract::Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470405
更新日期:1991-02-20 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31079
更新日期:2018-02-01 00:00:00
abstract::Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28852
更新日期:2014-11-01 00:00:00
abstract::A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440406
更新日期:1989-10-15 00:00:00
abstract::This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960328)66:1<70::AID-IJC1
更新日期:1996-03-28 00:00:00
abstract::Cancer incidence rates and patterns are reported for a rural population, living in the Eastern Cape Province of South Africa for the period 1998-2002. The population-based cancer registry has operated for 20 years, using both active and passive methods for case finding, through collaborations with 19 health facilities...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25246
更新日期:2010-11-15 00:00:00
abstract::As the most abundant noncoding RNA in cells, tRNA plays an important role in tumorigenesis and development. The report of tRNA on the pathogenesis of lung adenocarcinoma is rare. It is of great clinical significance to explore the relationship between tRNA expression and prognosis of lung adenocarcinoma. The expressio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32250
更新日期:2019-10-01 00:00:00
abstract::Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridizati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25330
更新日期:2011-01-01 00:00:00
abstract::Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910140616
更新日期:1974-12-15 00:00:00
abstract::The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23834
更新日期:2008-12-01 00:00:00
abstract::Down-regulation of E-cadherin function is characteristic of cancer cells and might involve the small G-protein Rho family, including Rac1 and Cdc42. IQGAP1 has been reported to be one of the target proteins of Rac1 and Cdc42. To elucidate the role of IQGAP1 in cancer-cell adhesion, its expression was investigated in 4...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1121>3
更新日期:2001-03-15 00:00:00
abstract::Oligodeoxynucleotides containing CpG motifs (CpG-ODN) display broad immunostimulating activity and are currently under clinical trial in various malignancies, including recurrent glioblastomas. Combining CpG-ODN with another therapy that could induce antigen release might enhance tumor-specific immune response. We inv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21131
更新日期:2005-10-10 00:00:00
abstract::Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high proliferative and metastatic phenotypes. CDCA7, a new member of the cell division cycle associated family of genes, is involved in embryonic development and dysregulated in various types of human cancer. However, the biologi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31766
更新日期:2018-11-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31022
更新日期:2017-12-15 00:00:00
abstract::We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430618
更新日期:1989-06-15 00:00:00
abstract::Malignant glioma is one of the most aggressive cancers. For the development of effective therapeutic strategies against such malignant diseases, elucidation of molecular targets is necessary. We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24965
更新日期:2010-04-15 00:00:00
abstract::To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31962
更新日期:2019-05-15 00:00:00
abstract::Immunotherapy targeting programmed cell death-1 (PD-1) has become a standard pharmacological therapy. Although tumor mutation burden level was reported to depend on the tumor location in nonsmall cell lung cancer (NSCLC), predictive impact of the tumor location on the response to anti-PD-1 therapy is unknown. Two hund...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33030
更新日期:2020-10-15 00:00:00
abstract::Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991022)84:5<516::aid-ijc
更新日期:1999-10-22 00:00:00
abstract::Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only a few months and drug resistance develops thereafter in many cases. It has been acknowledged th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25985
更新日期:2012-01-15 00:00:00
abstract::The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370619
更新日期:1986-06-15 00:00:00