Abstract:
:Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compounds by tumor cells. Influx of the anti-folate methotrexate via the reduced-folate carrier system of CCRF-CEM cells was found to be highly sensitive to inhibition by suramin but not to various other arylsulfonic acids. Inhibition by suramin was competitive, and the inhibition constant Ki was 1.3 microM, a value 3-fold lower than the Kt for half-maximal influx of methotrexate. Folate binding to the membrane-associated folate-binding protein of KB cells was not affected by suramin. Growth studies revealed that the response of human CCRF-CEM, KB, PC-3 and MCF-7 cells to methotrexate was antagonized from 6- to 17-fold by pharmacological levels (10-200 microM) of suramin. Conversely, growth inhibition was additive or synergistic when suramin was combined with metoprine, a lipophilic anti-folate which enters cells by diffusion. Synergism was observed between metoprine and suramin in CCRF-CEM cells, which take up folate exclusively through the reduced-folate carrier (inhibitable by suramin), whereas additivity was observed for KB cells, which rely largely on the folate-binding protein (unaffected by suramin) for folate import. Our results indicate that inhibition of cellular transport of folate compounds may explain part of the anti-neoplastic effects of suramin on tumor cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Rideout DC,Bustamante A,Patel R,Henderson GBdoi
10.1002/ijc.2910610616subject
Has Abstractpub_date
1995-06-09 00:00:00pages
840-7issue
6eissn
0020-7136issn
1097-0215journal_volume
61pub_type
杂志文章abstract::Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560220
更新日期:1994-01-15 00:00:00
abstract::Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24506
更新日期:2009-10-15 00:00:00
abstract::The relationship between the strength of the estrogenic and progestational components of combined oral contraceptives and risk of endometrial carcinoma was examined in a multinational hospital-based case-control study comparing 220 cases from 7 countries with 1,537 age- and hospital-matched controls. Oral contraceptiv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490612
更新日期:1991-12-02 00:00:00
abstract::There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28988
更新日期:2014-10-15 00:00:00
abstract::Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380417
更新日期:1986-10-15 00:00:00
abstract::There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25479
更新日期:2011-04-01 00:00:00
abstract::Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280208
更新日期:1981-08-15 00:00:00
abstract::Intratumoural (i.t.) injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma. Here, biodistribution of [(125)I]IdUrd was evaluated 5 hr after i.t. injection in subcutaneous human glioblastoma xenografts LN229 after di...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20112
更新日期:2004-05-20 00:00:00
abstract::Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are not only taken up by tumour(s) but also by normal liver. The accumulation of radionuclides in this organ poses a major problem to the use of radiolabelled antibodies as diagnostic and therapeutic tools. In an attempt to unders...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500616
更新日期:1992-04-01 00:00:00
abstract::Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.27441
更新日期:2012-06-15 00:00:00
abstract::The recently identified cell adhesion regulator (CAR) modulates the process of integrin-mediated cell adhesion. The CAR gene is located on 16q, a locus at which high levels of allelic losses have been demonstrated in advanced human hepatocellular carcinoma (HCC). We studied the possible involvement of the CAR gene in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970620)74:3<251::aid-ijc
更新日期:1997-06-20 00:00:00
abstract::In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29918
更新日期:2016-06-01 00:00:00
abstract::Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470217
更新日期:1991-01-21 00:00:00
abstract::We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430108
更新日期:1989-01-15 00:00:00
abstract::The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430305
更新日期:1989-03-15 00:00:00
abstract::The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23470
更新日期:2008-06-15 00:00:00
abstract::To probe the potential contribution of beta-galactoside-contributing epitopes and receptor proteins (gal-1 and gal-3) to colon malignancy, we first examined the expression of galectins and binding sites in clinical specimens by lectin and immunohistochemistry. Sixty-seven colonic surgical resections were studied, incl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10843
更新日期:2003-01-20 00:00:00
abstract::A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500613
更新日期:1992-04-01 00:00:00
abstract::The purpose of our study was to investigate a novel therapeutic approach for rhabdomyosarcoma (RMS) in an animal model. The pursuit of new therapeutic modalities for RMS is critically important since this type of tumor is the most common soft tissue sarcoma in children and because patients with metastatic disease may ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961127)68:5<596::AID-IJC
更新日期:1996-11-27 00:00:00
abstract::The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1564
更新日期:2002-01-01 00:00:00
abstract::The role of miRNAs with tumor suppressive activity in liver cancer has been well studied. However, little is known about potential oncomiRs in HCC. In our study, we conducted a systematic evaluation of candidate oncomiRs and found that upregulation of miR-18a and miR-25 in HCC was associated with poor patient survival...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31857
更新日期:2019-01-15 00:00:00
abstract::The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910610503
更新日期:1995-05-29 00:00:00
abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310518
更新日期:1983-05-15 00:00:00
abstract::While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched contro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31077
更新日期:2018-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25963
更新日期:2011-12-15 00:00:00
abstract::Natural cell-mediated immunity against autologous tumor cells, autologous endometrial epithelium, and allogeneic epidermoid carcinoma cell line HeLa was tested in 8 patients with endometrial carcinoma and one patient with endometrial stromal sarcoma. The average cytotoxicity of unstimulated peripheral blood lymphocyte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400408
更新日期:1987-10-15 00:00:00
abstract::Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram bod...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960927)68:1<114::AID-IJC
更新日期:1996-09-27 00:00:00
abstract::We have previously developed 3 monoclonal anti-idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small-cell lung carcinoma (SCLC)-associated sialoglycoprotein antigen sGP 90-135. The aim of this study was to compare the efficiencies o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500118
更新日期:1992-01-02 00:00:00
abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350107
更新日期:1985-01-15 00:00:00
abstract::Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut-derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also participates in liver regeneration after partial hepatectomy inducing hepatocellular proliferation. FGF19 is overexpressed in a significant proportion of human hepato...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29287
更新日期:2015-05-15 00:00:00