Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys).


:Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage contacts, were further tested by Western blotting. A large number of false-positive and a small number of false-negative ELISA sera were identified. Although most true positive reactions were directed to a single retrovirus, a number of individuals from 4 species were positive for more than one retrovirus. Specific seroreactivity to HTLV-I was found in 39/526 (7%) animals of 15 species. True positive reactions to SRV-I were found in 21/516 (4%) animals, including talapoins and 2 species of macaques. Specific serologic reactions to HTLV-III/LAV were detected in 23/526 (4%) monkeys. Many of the HTLV-III/LAV seropositive animals were from one mixed-species zoo exhibit, containing sooty mangabeys, mandrills, Kolb's guenons, and talapoins. A type D virus was isolated from the blood of 3/10 SRV-I antibody-positive Tonkeana macaques, but from none of 11 seropositive talapoins. A lentivirus was isolated from the blood of 4/7 HTLV-III/LAV seropositive sooty mangabeys, but not from seropositive talapoins in the same exhibit or from 2 seropositive colobus from another zoo. The sooty mangabey lentivirus produced generalized lymphadenopathy, leukopenia, and decreased levels of T4 lymphocytes in 2 experimentally infected rhesus macaques.


Int J Cancer


Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB




Has Abstract


1986-10-15 00:00:00












  • Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells.

    abstract::Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is little direct evidence on how the genetic heterogeneity impacts on drug response profiles of the cancer cells. Our goal was to determine how genomic clonal evolution...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saeed K,Ojamies P,Pellinen T,Eldfors S,Turkki R,Lundin J,Järvinen P,Nisen H,Taari K,Af Hällström TM,Rannikko A,Mirtti T,Kallioniemi O,Östling P

    更新日期:2019-03-15 00:00:00

  • Properties of recombinant interleukin 2-cultured tumor-infiltrating lymphocytes in human lung cancer.

    abstract::It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

    更新日期:1989-04-15 00:00:00

  • DCC gene alteration in human endometrial carcinomas.

    abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gima T,Kato H,Honda T,Imamura T,Sasazuki T,Wake N

    更新日期:1994-05-15 00:00:00

  • Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer.

    abstract::The next-generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patient responses are variable, and survival benefit remains relatively small. Developing effective modality to improve MDV3100 efficacy is urgently needed. Recent eviden...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhan Y,Cao B,Qi Y,Liu S,Zhang Q,Zhou W,Xu D,Lu H,Sartor O,Kong W,Zhang H,Dong Y

    更新日期:2013-11-01 00:00:00

  • Malignant neoplasms in cyclosporin A-induced autoimmunity (CyA-AI).

    abstract::Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms of disease resembling graft-vs.-host disease (GVHD) as seen after allogeneic bone-marrow transplantation. Symptoms of disease may include acute dermatit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wodzig KW,Beijleveld LJ,Damoiseaux JG,Arends JW,van Breda Vriesman PJ

    更新日期:1997-07-29 00:00:00

  • BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells.

    abstract::Cancer stem cells (CSCs) are initiating cells in colorectal cancer (CRC). Colorectal tumours undergo epithelial to mesenchymal transition (EMT)-like processes at the invasive front, enabling invasion and metastasis, and recent studies have linked this process to the acquisition of stem cell-like properties. It is of f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sarkar D,Shields B,Davies ML,Müller J,Wakeman JA

    更新日期:2012-01-15 00:00:00

  • Tumor-associated macrophage-targeted therapeutics in ovarian cancer.

    abstract::Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influen...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: An Y,Yang Q

    更新日期:2020-11-24 00:00:00

  • Estrogen and progesterone receptor mRNA levels in primary breast cancer: association with patient survival and other clinical and tumor features.

    abstract::The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

    更新日期:1994-11-01 00:00:00

  • Ganglioside expression on human malignant melanoma assessed by quantitative immune thin-layer chromatography.

    abstract::The ganglioside composition of 20 human malignant melanomas and 5 normal tissues (muscle, spleen, kidney, liver and brain) was analyzed by high-performance thin-layer chromatography (HPTLC) and immune HPTLC using a panel of antiganglioside monoclonal antibodies, and quantified by photodensitometry. The most prominent ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hamilton WB,Helling F,Lloyd KO,Livingston PO

    更新日期:1993-02-20 00:00:00

  • Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.

    abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fenton JI,Birmingham JM,Hursting SD,Hord NG

    更新日期:2008-06-01 00:00:00

  • Site distribution of different types of skin cancer: new aetiological clues.

    abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Franceschi S,Levi F,Randimbison L,La Vecchia C

    更新日期:1996-07-03 00:00:00

  • Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22.

    abstract::Using differential screening of a breast cancer cDNA library, we isolated a cDNA encoding the psoriasin (S100A7) protein, previously identified in psoriatic epidermis. In the present study, we demonstrate that the psoriasin gene is expressed in breast cancer cell lines and in cancer cells of some breast carcinomas but...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moog-Lutz C,Bouillet P,Régnier CH,Tomasetto C,Mattei MG,Chenard MP,Anglard P,Rio MC,Basset P

    更新日期:1995-10-09 00:00:00

  • Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro.

    abstract::Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteoly...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hashim YZ,Rowland IR,McGlynn H,Servili M,Selvaggini R,Taticchi A,Esposto S,Montedoro G,Kaisalo L,Wähälä K,Gill CI

    更新日期:2008-02-01 00:00:00

  • Tumor-promoting activity of 2,4-dinitrofluorobenzene.

    abstract::The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maldve RE,Fischer SM

    更新日期:1995-02-08 00:00:00

  • Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics.

    abstract::To develop a prognostic biomarker for esophageal squamous cell carcinoma (ESCC), we examined the proteomic profile of ESCC using two-dimensional difference gel electrophoresis (2D-DIGE), and identified proteins associated with prognosis by mass spectrometry. The prognostic performance of the identified proteins was ex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Uemura N,Nakanishi Y,Kato H,Saito S,Nagino M,Hirohashi S,Kondo T

    更新日期:2009-05-01 00:00:00

  • Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity.

    abstract::Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ge K,Duhadaway J,Sakamuro D,Wechsler-Reya R,Reynolds C,Prendergast GC

    更新日期:2000-02-01 00:00:00

  • Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.

    abstract::Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU. Therefore, we examined whether mechanistic differences in cell death could underlie their different ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bijnsdorp IV,Peters GJ,Temmink OH,Fukushima M,Kruyt FA

    更新日期:2010-05-15 00:00:00

  • Occupational sun exposure and risk of melanoma according to anatomical site.

    abstract::Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations between occupational (more continuous pattern) sun exposure and melanoma risk. The association of melanoma with occupational sun exposure may differ according to anatomical ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vuong K,McGeechan K,Armstrong BK,AMFS Investigators.,GEM Investigators.,Cust AE

    更新日期:2014-06-01 00:00:00

  • STLV-I antibodies in feral populations of East African vervet monkeys (Cercopithecus aethiops).

    abstract::Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

    更新日期:1986-10-15 00:00:00

  • Changing role of 3 screening modalities in the European randomized study of screening for prostate cancer (Rotterdam).

    abstract::A randomized screening trial was started in Europe to show the effect of early detection and treatment of prostate cancer on mortality (European Study on Screening of Prostate Cancer). In one centre (Rotterdam), the screening protocol initially consisted of 3 screening tests for all men: prostate-specific antigen (PSA...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beemsterboer PM,Kranse R,de Koning HJ,Habbema JD,Schröder FH

    更新日期:1999-08-20 00:00:00

  • Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma.

    abstract::Membrane-bound complement regulatory proteins provide tumor cells with protection from antibody and complement in vitro. However, complement regulators are widely expressed on normal tissue, and inhibiting the function of complement regulatory proteins on tumor cells in vivo has not been investigated due to the absenc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Imai M,Ohta R,Okada N,Tomlinson S

    更新日期:2004-07-20 00:00:00

  • Induction of acquired resistance to antiestrogen by reversible mitochondrial DNA depletion in breast cancer cell line.

    abstract::Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone-independence in prostate cancer. He...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naito A,Carcel-Trullols J,Xie CH,Evans TT,Mizumachi T,Higuchi M

    更新日期:2008-04-01 00:00:00

  • Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer.

    abstract::Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nicholson LJ,Smith PR,Hiller L,Szlosarek PW,Kimberley C,Sehouli J,Koensgen D,Mustea A,Schmid P,Crook T

    更新日期:2009-09-15 00:00:00

  • Cervical cancer cell-derived interleukin-6 impairs CCR7-dependent migration of MMP-9-expressing dendritic cells.

    abstract::Cervical carcinogenesis is a consequence of persistent infection with high-risk human papillomaviruses (HPVs). Recent studies indicate that HPV-transformed cells actively instruct their microenvironment to promote carcinogenesis. Here, we demonstrate that cervical cancer cells activate monocytes to produce their own C...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pahne-Zeppenfeld J,Schröer N,Walch-Rückheim B,Oldak M,Gorter A,Hegde S,Smola S

    更新日期:2014-05-01 00:00:00

  • Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.

    abstract::Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

    更新日期:2020-08-15 00:00:00

  • Measurement of a pancreatic cancer-associated antigen (DU-PAN-2) detected by a monoclonal antibody in sera of patients with digestive cancers.

    abstract::DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sawabu N,Toya D,Takemori Y,Hattori N,Fukui M

    更新日期:1986-05-15 00:00:00

  • Diabetes and risk of esophageal and gastric adenocarcinomas.

    abstract::Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang X,Bernstein L,Tseng CC,Wu AH

    更新日期:2012-09-15 00:00:00

  • Impaired general cell-mediated immune functions in vivo and in vitro in patients with nasopharyngeal carcinoma.

    abstract::General cell-mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty-eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty-three (65.2%) of 66 untreate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chan SH,Chew TS,Goh EH,Simons MJ,Shanmugaratnam K

    更新日期:1976-08-15 00:00:00

  • Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumour lymphatic-homing peptide LyP-1.

    abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

    更新日期:2009-05-01 00:00:00

  • Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

    abstract::It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Davies M,Paterson IC,Ganapathy A,Prime SS

    更新日期:2006-12-15 00:00:00