Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation.

Abstract:

:Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed a solitary lymphoproliferative lesion in the porta hepatis 9 months after orthotopic liver transplant. Following reduction in immunosuppression with no response, she was treated with involved field radiotherapy utilizing CT-based treatment planning. A partial radiographic response was obtained, and she has not developed disease in the engrafted liver or systemically. Based on the present case report, involved field radiotherapy seems to be a reasonable treatment option for patients with localized PTLD. Int. J. Cancer (Radiat. Oncol. Invest.) 90:104-109, 2000.

journal_name

Int J Cancer

authors

Koffman BH,Kennedy AS,Heyman M,Colonna J,Howell C

doi

10.1002/(sici)1097-0215(20000420)90:2<104::aid-ijc

keywords:

subject

Has Abstract

pub_date

2000-04-20 00:00:00

pages

104-9

issue

2

eissn

0020-7136

issn

1097-0215

pii

10.1002/(SICI)1097-0215(20000420)90:2<104::AID-IJC

journal_volume

90

pub_type

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