Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis.


:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.


Int J Cancer


Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu




Has Abstract


2020-10-31 00:00:00






  • Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: a randomized controlled trial.

    abstract::Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combine...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nagao T,Warnakulasuriya S,Nakamura T,Kato S,Yamamoto K,Fukano H,Suzuki K,Shimozato K,Hashimoto S

    更新日期:2015-04-01 00:00:00

  • Mitotic activity, apoptosis and TRPM-2 mRNA expression in DMBA-induced rat mammary carcinoma treated with anti-estrogen toremifene.

    abstract::Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huovinen R,Wärri A,Collan Y

    更新日期:1993-10-21 00:00:00

  • Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.

    abstract::Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

    更新日期:2009-04-01 00:00:00

  • Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells.

    abstract::Herein, we show that γδT, CD8(+) αβT lymphocytes and natural killer (NK) cells display a different sensitivity to survival signals delivered via NKG2D surface receptor. All the three effector cell populations activate Akt1/PKBalpha through the engagement of this molecule. Upon binding to leukemic cells expressing NKG2...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Poggi A,Zancolli M,Boero S,Catellani S,Musso A,Zocchi MR

    更新日期:2011-07-15 00:00:00

  • Establishment and in vivo characterization of multidrug-resistant dunning R3327 rat prostate-carcinoma cell-lines.

    abstract::We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bashir I,Sikora K,Abel P,Foster CS

    更新日期:1994-06-01 00:00:00

  • Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatus.

    abstract::Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koshiol JE,Schroeder JC,Jamieson DJ,Marshall SW,Duerr A,Heilig CM,Shah KV,Klein RS,Cu-Uvin S,Schuman P,Celentano D,Smith JS

    更新日期:2006-10-01 00:00:00

  • Rapid quantification of HTLV-I provirus load: detection of monoclonal proliferation of HTLV-I-infected cells among blood donors.

    abstract::In this report, we quantified HTLV-I provirus load using the AmpliSensor system, which utilizes fluorescence to measure PCR products. With this method, provirus loads could be measured within 6 hr, and the results obtained correlated well with those obtained by other methods. Samples from 256 blood donors, who were po...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Etoh K,Yamaguchi K,Tokudome S,Watanabe T,Okayama A,Stuver S,Mueller N,Takatsuki K,Matsuoka M

    更新日期:1999-06-11 00:00:00

  • Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells.

    abstract::Hormone refractory prostate cancer poses a huge problem and standard of care chemotherapy has not been very successful. We used a novel strategy to combine properties of 2 well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. Bearing in mind th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desai D,Sinha I,Null K,Wolter W,Suckow MA,King T,Amin S,Sinha R

    更新日期:2010-07-01 00:00:00

  • Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells.

    abstract::We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Williams BA,Makrigiannis AP,Blay J,Hoskin DW

    更新日期:1997-11-04 00:00:00

  • Expression of the tyrosine kinase c-kit is an independent prognostic factor in patients with small cell lung cancer.

    abstract::In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rohr UP,Rehfeld N,Pflugfelder L,Geddert H,Müller W,Steidl U,Fenk R,Gräf T,Schott M,Thiele KP,Gabbert HE,Germing U,Kronenwett R,Haas R

    更新日期:2004-08-20 00:00:00

  • Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.

    abstract::Recent genome-wide scans identified several novel breast cancer risk alleles, including variants of the FGFR2, MAP3K1 and LSP1 genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation between the number of FGFR2 minor alleles a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gates MA,Tworoger SS,Terry KL,De Vivo I,Hunter DJ,Hankinson SE,Cramer DW

    更新日期:2009-02-01 00:00:00

  • Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.

    abstract::TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kocher T,Zheng M,Bolli M,Simon R,Forster T,Schultz-Thater E,Remmel E,Noppen C,Schmid U,Ackermann D,Mihatsch MJ,Gasser T,Heberer M,Sauter G,Spagnoli GC

    更新日期:2002-08-20 00:00:00

  • Osteopontin expression in a group of lymph node negative breast cancer patients.

    abstract::The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tuck AB,O'Malley FP,Singhal H,Harris JF,Tonkin KS,Kerkvliet N,Saad Z,Doig GS,Chambers AF

    更新日期:1998-10-23 00:00:00

  • Variations in serum alkaline DNase activity in rats during growth and treatment of tumors sensitive or resistant to therapy.

    abstract::Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Economidou-Karaoglou A,Brasseur F,Lans M,Taper HS,Roberfroid MB

    更新日期:1989-05-15 00:00:00

  • Variants at chromosome 20 (ASIP locus) and melanoma risk.

    abstract::Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. We genotyped 837 melanoma cases and 1,154 controls for 21 single nucleotide polymorphisms (SNPs) informative for 495 polymorphisms at the locus. Our data showe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maccioni L,Rachakonda PS,Scherer D,Bermejo JL,Planelles D,Requena C,Hemminki K,Nagore E,Kumar R

    更新日期:2013-01-01 00:00:00

  • Ly-6C+ natural T (NT) cells mediate immune surveillance against NK-sensitive and NK-resistant transplantable tumours in certain strains of mice.

    abstract::We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Martiniello R,Burton RC,Smart YC

    更新日期:1996-05-16 00:00:00

  • Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

    abstract::Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kerbel RS,Pross HF,Leibovitz A

    更新日期:1977-11-15 00:00:00

  • Cancer risk among patients with condylomata acuminata.

    abstract::Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a la...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nordenvall C,Chang ET,Adami HO,Ye W

    更新日期:2006-08-15 00:00:00

  • Apoptosis induced by low-dose paclitaxel is associated with p53 upregulation in nasopharyngeal carcinoma cells.

    abstract::Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

    更新日期:2002-01-10 00:00:00

  • Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

    abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro A

    更新日期:2006-12-01 00:00:00

  • Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells.

    abstract::Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abdulkarim B,Sabri S,Deutsch E,Vaganay S,Marangoni E,Vainchenker W,Bongrand P,Busson P,Bourhis J

    更新日期:2000-04-15 00:00:00

  • Long-term C-cell-mediated immunity to Epstein-Barr virus in man. II. Components necessary for regression in virus-infected leukocyte cultures.

    abstract::Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rickinson AB,Moss DJ,Pope JH

    更新日期:1979-05-15 00:00:00

  • Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response.

    abstract::Polyisoprenylated benzophenones derived from Garcinia xanthochymus have cytotoxic activity in vitro and antitumor activity in rodent models, but the mechanism is unknown. The purpose of our study was to examine in parallel molecular pathways that are targeted by 3 Garcinia-derived benzophenones-xanthochymol (X), gutti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Protiva P,Hopkins ME,Baggett S,Yang H,Lipkin M,Holt PR,Kennelly EJ,Bernard WI

    更新日期:2008-08-01 00:00:00

  • Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.

    abstract::Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Minicozzi P,Van Eycken L,Molinie F,Innos K,Guevara M,Marcos-Gragera R,Castro C,Rapiti E,Katalinic A,Torrella A,Žagar T,Bielska-Lasota M,Giorgi Rossi P,Larrañaga N,Bastos J,Sánchez MJ,Sant M,European HR Working Group on

    更新日期:2019-05-01 00:00:00

  • Suppression of Friend leukemia virus by Bacillus Calmette-Guérin and a streptococcal preparation, OK-432.

    abstract::OK-432, a streptococcal preparation, and BCG effectively inhibited splenomegaly in Friend leukemia virus (FLV)-infected mice. Divided drug dosage resulted in stronger inhibition than single administration. When the second dose was fixed at the 3rd pre-infection day, the best timing for the first dose was approximately...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

    更新日期:1980-01-15 00:00:00

  • Occupational X-ray examinations and lung cancer risk.

    abstract::Occupational X-ray examination programs have been conducted in many countries to screen for occupational and nonoccupational respiratory diseases, resulting in widespread exposure to X-radiation. We conducted a multicentre case-control study of lung cancer in the Czech Republic, Hungary, Poland, Romania, Russia and Sl...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Boffetta P,Mannetje A,Zaridze D,Szeszenia-Dabrowska N,Rudnai P,Lissowska J,Fabiánová E,Mates D,Bencko V,Navratilova M,Janout V,Cardis E,Fevotte J,Fletcher T,Brennan P

    更新日期:2005-06-10 00:00:00

  • A tumor-associated antigen expressed in melanoma cells with lower malignant potential.

    abstract::The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Suter L,Brüggen J,Bröcker EB,Sorg C

    更新日期:1985-06-15 00:00:00

  • Diet and pharyngeal cancer.

    abstract::A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rossing MA,Vaughan TL,McKnight B

    更新日期:1989-10-15 00:00:00

  • Suppressor cell activity in melanoma patients. II. Concanavalin A-induced suppressor cells in relation to tumor growth and suppressor T-cell subsets.

    abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Werkmeister J,Phillips G,McCarthy W,Hersey P

    更新日期:1981-07-15 00:00:00

  • The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.

    abstract::The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer. Sequence analysis showed a 45% homology to the human ubiquitin-activating enzyme E1 at the amino acid level. To further characterize the protein product, we generated UBE1L protein-specific antibodies. Immuno...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McLaughlin PM,Helfrich W,Kok K,Mulder M,Hu SW,Brinker MG,Ruiters MH,de Leij LF,Buys CH

    更新日期:2000-03-15 00:00:00