当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Relationship of tumor-specific transplantation antigens to the histocompatibility complex: dissociation of in vitro alloantigen expression and in vivo alloimmunity from tumor-specific transplantation antigen strength.

Relationship of tumor-specific transplantation antigens to the histocompatibility complex: dissociation of in vitro alloantigen expression and in vivo alloimmunity from tumor-specific transplantation antigen strength.

Abstract：

:The studies reported here explore the relationship between tumor-specific transplantation antigens (TSTA) and (1) the expression of serologically defined specificities, and (2) the immunogenicity of H-2K- or H-2D-determined alloantigens on methylcholanthrene (MCA)-induced murine fibrosarcomas. Expression of H-2K and H-2D serologically-detected private specificities on groups of tumors raised in B10.A, B10.BR or B10.D2 strains varied greatly among tumors. No regular reciprocal or direct relationship to tumor TSTA strength was found. Each tumor, however, expressed H-2K or H-2D alloantigens stably as determined by direct cytotoxicity or absorption techniques. Even those tumors expressing little or no detectable alloantigen by serologic analysis were immunogenic in H-2K or H-2D incompatible congeneic hosts. This was assayed in terms of capacity to evoke primary or secondary tumor resistance, and to induce allo-antibody toward private H-2K or H-2D end specificities. An exception was that B10.BR tumors failed to induce anti-H-2Dk antibody despite strong surface alloantigen expression. While TSTA strength did not correlate with serologically detected alloantigen expression, TSTA strength did tend to correlate inversely with capacity to resist primary growth in the H-2K different host, and directly with resistance in the H-2D different host.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Chauvenet PH,Smith RT

doi

10.1002/ijc.2910220115

subject

Has Abstract

pub_date

1978-07-15 00:00:00

pages

79-90

issue

1

eissn

0020-7136

issn

1097-0215

journal_volume

22

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia.

    abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910270310

    authors： Ziegler HW,Kay NE,Zarling JM

    更新日期：1981-03-15 00:00:00

  • High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

    abstract：:Expression of the candidate metastasis-suppressor gene nm23-H1 has been shown to correlate inversely with metastatic potential in some human tumors, but not in all. Until now, few studies have been carried out on the activity of the homologous nm23-H2 gene in human cancer. No nm23 transcription studies exist for human...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910550306

    authors： Engel M,Theisinger B,Seib T,Seitz G,Huwer H,Zang KD,Welter C,Dooley S

    更新日期：1993-09-30 00:00:00

  • HIPEC ROC I: a phase I study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancer.

    abstract：:This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29011

    authors： Zivanovic O,Abramian A,Kullmann M,Fuhrmann C,Coch C,Hoeller T,Ruehs H,Keyver-Paik MD,Rudlowski C,Weber S,Kiefer N,Poelcher ML,Thiesler T,Rostamzadeh B,Mallmann M,Schaefer N,Permantier M,Latten S,Kalff J,Thomale J,

    更新日期：2015-02-01 00:00:00

  • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.

    abstract：:Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24758

    authors： Guenther A,Gordon S,Tiemann M,Burger R,Bakker F,Green JR,Baum W,Roelofs AJ,Rogers MJ,Gramatzki M

    更新日期：2010-01-01 00:00:00

  • Inhibition of cis-diamminedichloroplatinum (II)-induced DNA interstrand cross-link removal by 7-ethyl-10-hydroxy-camptothecin in HST-1 human squamous-carcinoma cells.

    abstract：:The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910620114

    authors： Masumoto N,Nakano S,Esaki T,Fujishima H,Tatsumoto T,Niho Y

    更新日期：1995-07-04 00:00:00

  • Glycemic index, glycemic load and risk of prostate cancer.

    abstract：:Dietary carbohydrates have different glycemic and insulinemic potentials depending on type (glycemic index, GI) and amount (glycemic load, GL) of carbohydrate consumed or both. Insulin in turn has been implicated as a risk factor for several cancers, including that of the prostate. We assessed the relationship of GI a...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.20416

    authors： Augustin LS,Galeone C,Dal Maso L,Pelucchi C,Ramazzotti V,Jenkins DJ,Montella M,Talamini R,Negri E,Franceschi S,La Vecchia C

    更新日期：2004-11-10 00:00:00

  • Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase.

    abstract：:Allelic loss at the short arm of chromosome 11 is one of the most common and potent events in the progression and metastasis of breast cancer. Here, we present evidence that the Integrin-Linked Kinase (ILK) gene maps to the commonly deleted chromosome 11p15.5 and suppresses malignant growth of human breast cancer cell...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20340

    authors： Chen P,Shen WZ,Karnik P

    更新日期：2004-10-10 00:00:00

  • Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules?

    abstract：:alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10141

    authors： Fiedler T,Walter W,Reichert TE,Maeurer MJ

    更新日期：2002-03-20 00:00:00

  • Dose-dependent regression of HeLa cell-derived tumours in SCID mice after parvovirus H-1 infection.

    abstract：:Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutica...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijc

    authors： Faisst S,Guittard D,Benner A,Cesbron JY,Schlehofer JR,Rommelaere J,Dupressoir T

    更新日期：1998-02-09 00:00:00

  • Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.

    abstract：:We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910510516

    authors： Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

    更新日期：1992-07-09 00:00:00

  • Cholera-toxin-enhanced growth of human breast cancer cell lines in vitro and in vivo: interaction with estrogen.

    abstract：:Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910360411

    authors： Sheffield LG,Welsch CW

    更新日期：1985-10-15 00:00:00

  • MicroRNA alterations in head and neck squamous cell carcinoma.

    abstract：:MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23831

    authors： Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

    更新日期：2008-12-15 00:00:00

  • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20754

    authors： Menendez JA,Vellon L,Colomer R,Lupu R

    更新日期：2005-05-20 00:00:00

  • Hot beverages and oesophageal cancer risk in western Kenya: Findings from the ESCCAPE case-control study.

    abstract：:Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis and poorly understood aetiology. Consumption of hot beverages-a probable carcinogen to humans-is associated with increased ESCC risk in other settings and is habitually practiced in Keny...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32032

    authors： Middleton DR,Menya D,Kigen N,Oduor M,Maina SK,Some F,Chumba D,Ayuo P,Osano O,Schüz J,McCormack V

    更新日期：2019-06-01 00:00:00

  • Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

    abstract：:In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910300411

    authors： Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

    更新日期：1982-10-15 00:00:00

  • Meta-iodobenzylguanidine induces growth inhibition and apoptosis of neuroendocrine gastrointestinal tumor cells.

    abstract：:Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10553

    authors： Höpfner M,Sutter AP,Beck NI,Barthel B,Maaser K,Jockers-Scherübl MC,Zeitz M,Scherübl H

    更新日期：2002-09-20 00:00:00

  • Qualitative and quantitative differences between Burkitt lymphoma and lymphoblastoid cell lines in the expression of membrane ecto-nucleotidases and in the response to agonists of the A2-type adenosine receptor.

    abstract：:The activity of ecto-nucleotidases has been determined on intact cells from Burkitt lymphoma (BL) and lymphoblastoid cell lines established in vitro (LCLs). BL cells never express ecto-5'-nucleotidase (5'-N) and exhibit only low levels of ecto-ATPase activity, whereas LCL-cells usually express both enzymes to varying ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910410321

    authors： Gutensohn W,Jahn H

    更新日期：1988-03-15 00:00:00

  • Heterogeneous expression of melanoma-associated antigens and HLA-A2 in metastatic melanoma in vivo.

    abstract：:MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19980209)75:4<517::aid-ijc

    authors： Cormier JN,Hijazi YM,Abati A,Fetsch P,Bettinotti M,Steinberg SM,Rosenberg SA,Marincola FM

    更新日期：1998-02-09 00:00:00

  • Low serum miR-19a expression as a novel poor prognostic indicator in multiple myeloma.

    abstract：:Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29199

    authors： Hao M,Zang M,Wendlandt E,Xu Y,An G,Gong D,Li F,Qi F,Zhang Y,Yang Y,Zhan F,Qiu L

    更新日期：2015-04-15 00:00:00

  • Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitro.

    abstract：:Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910320103

    authors： Rupniak HT,Whelan RD,Hill BT

    更新日期：1983-07-15 00:00:00

  • Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.

    abstract：:In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour cells are relatively silent in MMP expression. To determine the tissue source of the most relevant MMPs, we xenografted HBC cell lines and HBC tissues into ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20763

    authors： Lafleur MA,Drew AF,de Sousa EL,Blick T,Bills M,Walker EC,Williams ED,Waltham M,Thompson EW

    更新日期：2005-04-20 00:00:00

  • Estrogen and progesterone receptor mRNA levels in primary breast cancer: association with patient survival and other clinical and tumor features.

    abstract：:The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910590310

    authors： Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

    更新日期：1994-11-01 00:00:00

  • Selective induction of endothelial cell tissue factor in the presence of a tumour-derived mediator: a potential mechanism of flavone acetic acid action in tumour vasculature.

    abstract：:Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910490219

    authors： Murray JC,Clauss M,Denekamp J,Stern D

    更新日期：1991-09-09 00:00:00

  • Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.

    abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28465

    authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

    更新日期：2014-03-15 00:00:00

  • Benefits of catch-up in vaccination against human papillomavirus in medium- and low-income countries.

    abstract：:Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28197

    authors： Baussano I,Lazzarato F,Ronco G,Dillner J,Franceschi S

    更新日期：2013-10-15 00:00:00

  • Dissecting the journey to breast cancer diagnosis in sub-Saharan Africa: Findings from the multicountry ABC-DO cohort study.

    abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.33209

    authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

    更新日期：2021-01-15 00:00:00

  • Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.

    abstract：:Polyamines are essential for cell growth and differentiation. Their specific uptake contributes to the regulation of intracellular polyamine levels. In this study, we describe the modulation of this transport mechanism in a rat tumoral pancreatic acinar cell line (AR4-2J) and analyze the transport system characteristi...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910490418

    authors： Nicolet T,Scemama JL,Pradayrol L,Berthélémy P,Seva C,Vaysse N

    更新日期：1991-10-21 00:00:00

  • Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study.

    abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.33008

    authors： Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

    更新日期：2020-10-15 00:00:00

  • Risk factors for renal-cell carcinoma in a French case-control study.

    abstract：:A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910550107

    authors： Benhamou S,Lenfant MH,Ory-Paoletti C,Flamant R

    更新日期：1993-08-19 00:00:00

  • Interleukin-6 produced by pancreatic carcinoma cells enhances humoral immune responses against tumor cells: a possible event in tumor regression.

    abstract：:Production of interleukin-6 (IL-6) by human pancreatic carcinoma cells inversely correlates with potentials for blood-borne metastasis to the liver in nude mice. IL-6 cDNA was transfected to PCI-43, one of our cultured pancreatic carcinoma cell lines that does not produce IL-6 and generates numerous metastases to the ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19980119)75:2<284::aid-ijc

    authors： Saito K,Ishikura H,Kishimoto T,Kawarada Y,Yano T,Takahashi T,Kato H,Yoshiki T

    更新日期：1998-01-19 00:00:00