Interleukin-6 produced by pancreatic carcinoma cells enhances humoral immune responses against tumor cells: a possible event in tumor regression.

abstract：:Spleen cells from mice infected with Friend leukemia virus (FLV) inoculated by the intravenous route give rise to macroscopically visible colonies in the spleens of normal F1 histocompatible hybrid hosts. A study of H-2 antigens as generic markers for identification of strains of origin of cells constituting the splee...

journal_title：International journal of cancer

authors： Wendling F,Tambourin PE

更新日期：1978-10-15 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...

journal_title：International journal of cancer

authors： Asleh K,Lyck Carstensen S,Tykjaer Jørgensen CL,Burugu S,Gao D,Won JR,Jensen MB,Balslev E,Laenkholm AV,Nielsen DL,Ejlertsen B,Nielsen TO

更新日期：2019-05-15 00:00:00

abstract：:We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the...

journal_title：International journal of cancer

authors： Nagy A,Balint I,Kovacs G

更新日期：2003-10-10 00:00:00

abstract：:A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...

journal_title：International journal of cancer

authors： Goasguen N,de Chaisemartin C,Brouquet A,Julié C,Prevost GP,Laurent-Puig P,Penna C

更新日期：2010-09-01 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...

journal_title：International journal of cancer

authors： Hori S,Wadhwa K,Pisupati V,Zecchini V,Ramos-Montoya A,Warren AY,Neal DE,Gnanapragasam VJ

更新日期：2017-04-15 00:00:00

abstract：:To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records ...

journal_title：International journal of cancer

authors： Dal Maso L,Rezza G,Zambon P,Tagliabue G,Crocetti E,Vercelli M,Zanetti R,Falcini F,Tonini G,Mangone L,De Lisi V,Ferretti S,Tumino R,Stanta G,Vitarelli S,Serraino D,Franceschi S,Cancer and AIDS Registry Linkage Study.

更新日期：2001-08-01 00:00:00

abstract：:CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti-CD30 antibody-based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor-alpha converting enzyme (TACE). This metalloproteinase rel...

journal_title：International journal of cancer

authors： Hansen HP,Matthey B,Barth S,Kisseleva T,Mokros T,Davies SJ,Beckett RP,Foelster-Holst R,Lange HH,Engert A,Lemke H

更新日期：2002-03-10 00:00:00

abstract：:Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

journal_title：International journal of cancer

authors： Frommel TO,Coon JS,Tsuruo T,Roninson IB

更新日期：1993-09-09 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:GC-binding factor 2 (GCF2), a transcriptional repressor that decreases the activity of several genes is capable of binding directly to the GC-rich sequence of the EGFR promoter and repressing the transcriptional activity of EGFR. In addition to its function as a transcriptional repressor, GCF2 can directly interact wi...

journal_title：International journal of cancer

authors： Ohtsuka H,Oikawa M,Ariake K,Rikiyama T,Motoi F,Katayose Y,Unno M,Johnson AC

更新日期：2011-10-01 00:00:00

abstract：:Arrest and lodgement of circulating tumor cells in the microvasculature is a prerequisite for metastasis formation. Aggregation of activated platelets and subsequent release of bioactive substances seem to influence the lodgement process. Since thrombocytopenia has been shown to reduce lodgement and since 5-HT is one ...

journal_title：International journal of cancer

authors： Skolnik G,Bagge U,Dahlström A,Ahlman H

更新日期：1984-04-15 00:00:00

abstract：:We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

journal_title：International journal of cancer

authors： Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

更新日期：1992-07-09 00:00:00

abstract：:Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...

journal_title：International journal of cancer

authors： Niho N,Mutoh M,Komiya M,Ohta T,Sugimura T,Wakabayashi K

更新日期：2007-10-15 00:00:00

abstract：:We report the inhibitory effect of 4-methylesculetin (ME), a 4-methylumbelliferone derivative, on hyaluronan (HA) synthesis by pancreatic cancer cells, and its resulting anticancer action. First, HA in cell culture was analyzed using competitive inhibition with hyaluronic acid-binding protein (HABP) to study HA synthe...

journal_title：International journal of cancer

authors： Hajime M,Shuichi Y,Makoto N,Masanori Y,Ikuko K,Atsushi K,Mutsuo S,Keiichi T

更新日期：2007-06-15 00:00:00

abstract：:We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

journal_title：International journal of cancer

authors： Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

更新日期：2000-01-01 00:00:00

abstract：:Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

journal_title：International journal of cancer

authors： Shabo I,Olsson H,Sun XF,Svanvik J

更新日期：2009-10-15 00:00:00

abstract：:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

journal_title：International journal of cancer

authors： Kasper JS,Liu Y,Giovannucci E

更新日期：2009-03-15 00:00:00

abstract：:Epigenome-wide association studies have established methylation patterns related to smoking, the major risk factor of lung cancer (LC), which are distinct from methylation profiles disclosed in LC patients. This study simultaneously investigated associations of smoking-associated and LC-related methylation markers wit...

journal_title：International journal of cancer

authors： Zhang Y,Breitling LP,Balavarca Y,Holleczek B,Schöttker B,Brenner H

更新日期：2016-12-01 00:00:00

abstract：:Seven-day-old mouse embryos were transplanted under the kidney capsule of adult syngeneic recipients which were either X-irradiated, treated with cyclophosphamide, splenectomized or immunized with teratocarcinoma cell lines prior to embryonic transplantation. The yield of malignant tumors was decreased in preirradiate...

journal_title：International journal of cancer

authors： Damjanov I,Bagasra O,Dominis M,Solter D

更新日期：1982-12-15 00:00:00

abstract：:Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-b...

journal_title：International journal of cancer

authors： Simard JF,Baecklund F,Chang ET,Baecklund E,Hjalgrim H,-Olov Adami H,Glimelius B,Smedby KE

更新日期：2013-06-01 00:00:00

abstract：:Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease, suggesting that additional host genetic alterations are necessary for...

journal_title：International journal of cancer

authors： Lockwood WW,Coe BP,Williams AC,MacAulay C,Lam WL

更新日期：2007-01-15 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

journal_title：International journal of cancer

authors： Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

更新日期：2003-11-01 00:00:00

abstract：:Tumor growth and metastasis of lacZ-transduced murine lymphoma ESbL cells inoculated into syngeneic DBA/2 mice are characterized by a transient plateau phase with a constant tumor diameter and low metastatic load, indicating a host response against the tumor. Here we show that endothelial cells participate in a T-cell...

journal_title：International journal of cancer

authors： Rocha M,Krüger A,Van Rooijen N,Schirrmacher V,Umansky V

更新日期：1995-11-03 00:00:00

abstract：:The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-...

journal_title：International journal of cancer

authors： Bure I,Braun A,Kayser C,Geddert H,Schaefer IM,Cameron S,Ghadimi MB,Ströbel P,Werner M,Hartmann A,Wiemann S,Agaimy A,Haller F,Moskalev EA

更新日期：2017-12-01 00:00:00

abstract：:High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...

journal_title：International journal of cancer

authors： Ballabio S,Craparotta I,Paracchini L,Mannarino L,Corso S,Pezzotta MG,Vescio M,Fruscio R,Romualdi C,Dainese E,Ceppi L,Calura E,Pileggi S,Siravegna G,Pattini L,Martini P,Delle Marchette M,Mangioni C,Ardizzoia A,Pelleg

更新日期：2019-11-15 00:00:00

abstract：:Phosphorylation/activation of c-jun NH2-terminal kinase (JNK) has an ambivalent role, pro-proliferation or antiproliferation, in human cancers, which is determined by different cell types and by its crosstalk with other kinases. So far, the role of phosphorylated JNK (p-JNK) in breast cancer is mostly undefined. In th...

journal_title：International journal of cancer

authors： Yeh YT,Hou MF,Chung YF,Chen YJ,Yang SF,Chen DC,Su JH,Yuan SS

更新日期：2006-06-01 00:00:00

abstract：:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

journal_title：International journal of cancer

authors： Werkmeister J,Phillips G,McCarthy W,Hersey P

更新日期：1981-07-15 00:00:00

abstract：:Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

journal_title：International journal of cancer

authors： Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

更新日期：2012-01-15 00:00:00