Suppressor cell activity in melanoma patients. II. Concanavalin A-induced suppressor cells in relation to tumor growth and suppressor T-cell subsets.


:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean percentage of T gamma cells was significantly higher (p less than 0.001) in melanoma patients before surgery (21.8 +/- 5.4) compared to a group of age-matched controls (14.9 +/- 5.4). There was a tendency for the proportion of T gamma cells in patients to decrease after surgery, although the relative levels of T gamma were still significantly elevated (p less than 0.05) 6-8 weeks after surgery when compared to normal controls. The mean percentage of T and B cells in melanoma patients before and after surgery was comparable to that observed in normal controls. The degree of Con-A-induced suppression in patients increased significantly after surgery particularly at 6-8 weeks (p less than 0.02). No difference in con-A-induced suppressor cell activity was observed between melanoma patients and controls before or after surgery. An inverse relationship was found between the amount of Con-A-induced suppression and percentage of T gamma cells in melanoma patients before surgery. Similar associations were not apparent in patients after surgery or in normal control populations. The inverse correlation of Con-A-induced suppression with T gamma cell numbers suggests that the former may measure potential suppressor cell activity whereas the T gamma cells may indicate active suppressor cells. The significance of these findings for the monitoring of suppressor cell activity in vivo and their role in suppression of immune responses in melanoma patients is discussed.


Int J Cancer


Werkmeister J,Phillips G,McCarthy W,Hersey P




Has Abstract


1981-07-15 00:00:00












  • A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study.

    abstract::High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lahmann PH,Lissner L,Gullberg B,Olsson H,Berglund G

    更新日期:2003-01-10 00:00:00

  • Parental smoking and risk of childhood brain tumors.

    abstract::Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milne E,Greenop KR,Scott RJ,Ashton LJ,Cohn RJ,de Klerk NH,Armstrong BK

    更新日期:2013-07-01 00:00:00

  • Exposure to environmental tobacco smoke and risk of adenocarcinoma of the lung.

    abstract::We conducted a case-control study of adenocarcinoma of the lung and exposure to environmental tobacco smoke (ETS) in 7 countries. We interviewed 70 cases of adenocarcinoma of the lung and 178 population or hospital controls. All subjects had smoked fewer than 400 cigarettes in their lifetimes. Ever exposure to ETS fro...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Boffetta P,Ahrens W,Nyberg F,Mukeria A,Brüske-Hohlfeld I,Fortes C,Constantinescu V,Simonato L,Batura-Gabryel H,Lea S,Gaborieau V,Benhamou S

    更新日期:1999-11-26 00:00:00

  • β-glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses.

    abstract::Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendri...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ning Y,Xu D,Zhang X,Bai Y,Ding J,Feng T,Wang S,Xu N,Qian K,Wang Y,Qi C

    更新日期:2016-06-01 00:00:00

  • Inhibition of syngeneic fibrosarcoma growth by lymphocytes sensitized on tumor-cell monolayers in the presence of the thymic humoral factor.

    abstract::The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Small M,Trainin N

    更新日期:1975-06-15 00:00:00

  • Circulating perivascular progenitors: a target of PDGFR inhibition.

    abstract::Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

    更新日期:2011-09-15 00:00:00

  • Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo.

    abstract::In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tang SJ,Ho MY,Cho HC,Lin YC,Sun GH,Chi KH,Wang YS,Jhou RS,Yang W,Sun KH

    更新日期:2008-12-15 00:00:00

  • Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma.

    abstract::Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

    更新日期:2012-02-15 00:00:00

  • Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.

    abstract::The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

    更新日期:2012-12-01 00:00:00

  • Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer.

    abstract::The next-generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patient responses are variable, and survival benefit remains relatively small. Developing effective modality to improve MDV3100 efficacy is urgently needed. Recent eviden...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhan Y,Cao B,Qi Y,Liu S,Zhang Q,Zhou W,Xu D,Lu H,Sartor O,Kong W,Zhang H,Dong Y

    更新日期:2013-11-01 00:00:00

  • Prognosis of early breast cancer by immunohistochemistry defined intrinsic sub-types in patients treated with adjuvant chemotherapy in the NEAT/BR9601 trial.

    abstract::Breast cancer can be classified into molecular sub-types that have distinct survival patterns. We evaluated the prognostic significance of breast cancer sub-types in a cohort of women taking part in the NEAT and BR9601 clinical trials comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with ECMF (epirubici...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ali AM,Provenzano E,Bartlett JM,Abraham J,Driver K,Munro AF,Twelves C,Poole CJ,Hiller L,Dunn JA,Earl HM,Caldas C,Pharoah PD

    更新日期:2013-09-15 00:00:00

  • Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

    abstract::XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

    更新日期:2003-01-01 00:00:00

  • How many cervical cancers are prevented by treatment of screen-detected disease in young women?

    abstract::Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sasieni P,Castanon A,Parkin DM

    更新日期:2009-01-15 00:00:00

  • BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.

    abstract::Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yin X,Zhang H,Lundgren K,Wilson L,Burrows F,Shores CG

    更新日期:2010-03-01 00:00:00

  • Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.

    abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang W,Sundquist K,Sundquist J,Ji J

    更新日期:2020-11-13 00:00:00

  • Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor-potentiating function.

    abstract::The human MUC1 gene expresses at least 2 type 1 membrane proteins: MUC1/REP, a polymorphic high m.w. MUC1 glycoprotein often highly expressed in breast cancer tissues and containing a variable number of tandem 20 amino acid repeat units, and the MUC1/Y protein, which lacks this repeat array and, therefore, is not poly...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Baruch A,Hartmann M,Zrihan-Licht S,Greenstein S,Burstein M,Keydar I,Weiss M,Smorodinsky N,Wreschner DH

    更新日期:1997-05-29 00:00:00

  • Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.

    abstract::Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

    更新日期:2013-11-01 00:00:00

  • CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

    abstract::The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. However, not much is known about the presence and function of Treg within tumors. Here we show in a syngeneic murine glioma model a time-dependent accumulation of CD4+Fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grauer OM,Nierkens S,Bennink E,Toonen LW,Boon L,Wesseling P,Sutmuller RP,Adema GJ

    更新日期:2007-07-01 00:00:00

  • Host STAT2/type I interferon axis controls tumor growth.

    abstract::The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well-documented in vitro. Yet evidence of IFN-activated STAT2 as having tumor suppressor function in vivo and participation in antitumor immunity is lacking. Here we show in a syngeneic tumor transplantation model that STAT2 reduces tu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yue C,Xu J,Tan Estioko MD,Kotredes KP,Lopez-Otalora Y,Hilliard BA,Baker DP,Gallucci S,Gamero AM

    更新日期:2015-01-01 00:00:00

  • Comparison between p53 protein measurements using the luminometric immunoassay and immunohistochemistry with detection of p53 gene mutations using cDNA sequencing in human breast tumors.

    abstract::The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Norberg T,Lennerstrand J,Inganäs M,Bergh J

    更新日期:1998-08-21 00:00:00

  • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

    abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:2001-02-15 00:00:00

  • Conundrums in screening for cancer.

    abstract::Screening for cancer has to be carefully organized for maximum effectiveness, and introduced in full understanding of the natural history of the disease. There are major potential harms as well as benefits from screening. The current state of art for breast, cervix and prostate cancer screening is reviewed, only for b...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Miller AB

    更新日期:2010-03-01 00:00:00

  • DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats.

    abstract::3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bieler CA,Cornelius MG,Klein R,Arlt VM,Wiessler M,Phillips DH,Schmeiser HH

    更新日期:2005-10-10 00:00:00

  • Anti-tumor effects of recombinant human macrophage colony-stimulating factor, alone or in combination with local irradiation, in mice inoculated with Lewis lung carcinoma cells.

    abstract::Recombinant human (rhu) macrophage colony-stimulating factor (M-CSF) was evaluated for efficacy, either alone or in combination with local X-irradiation (LR), in mice inoculated subcutaneously (s.c.) with Lewis lung carcinoma (LLC) cells. The size of the primary tumor and numbers of lung metastases, 21 days after tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lu L,Shen RN,Lin ZH,Aukerman SL,Ralph P,Broxmeyer HE

    更新日期:1991-01-02 00:00:00

  • Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein.

    abstract::The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro as well as in can...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Niv R,Assaraf YG,Segal D,Pirak E,Reiter Y

    更新日期:2001-12-15 00:00:00

  • Cell proliferation in 3,800 node-negative breast cancers: consistency over time of biological and clinical information provided by 3H-thymidine labelling index.

    abstract::For breast cancer, many prognostic markers that initially appeared promising have failed to maintain their clinical predictive value. Few reports have analyzed the consistency over time of biological and clinical information provided by biomarkers. Tumour cell proliferation has acquired relevance as an indicator of pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Silvestrini R,Daidone MG,Luisi A,Mastore M,Leutner M,Salvadori B

    更新日期:1997-02-20 00:00:00

  • Increased levels of 5-fluorouracil-induced DNA lesions in Bloom's syndrome.

    abstract::In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lönn U,Lönn S,Nylen U,Winblad G

    更新日期:1990-03-15 00:00:00

  • DCC gene alteration in human endometrial carcinomas.

    abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gima T,Kato H,Honda T,Imamura T,Sasazuki T,Wake N

    更新日期:1994-05-15 00:00:00

  • Implementation of the 7th edition AJCC staging system: Effects on staging and survival for pT1 melanoma. A Dutch population based study.

    abstract::In the 7th edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oude Ophuis CM,Louwman MW,Grünhagen DJ,Verhoef K,van Akkooi AC

    更新日期:2017-04-15 00:00:00

  • Melanoma in Western Australia 1975-76 to 1980-81: trends in demographic and pathological characteristics.

    abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

    更新日期:1986-02-15 00:00:00