Abstract:
:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean percentage of T gamma cells was significantly higher (p less than 0.001) in melanoma patients before surgery (21.8 +/- 5.4) compared to a group of age-matched controls (14.9 +/- 5.4). There was a tendency for the proportion of T gamma cells in patients to decrease after surgery, although the relative levels of T gamma were still significantly elevated (p less than 0.05) 6-8 weeks after surgery when compared to normal controls. The mean percentage of T and B cells in melanoma patients before and after surgery was comparable to that observed in normal controls. The degree of Con-A-induced suppression in patients increased significantly after surgery particularly at 6-8 weeks (p less than 0.02). No difference in con-A-induced suppressor cell activity was observed between melanoma patients and controls before or after surgery. An inverse relationship was found between the amount of Con-A-induced suppression and percentage of T gamma cells in melanoma patients before surgery. Similar associations were not apparent in patients after surgery or in normal control populations. The inverse correlation of Con-A-induced suppression with T gamma cell numbers suggests that the former may measure potential suppressor cell activity whereas the T gamma cells may indicate active suppressor cells. The significance of these findings for the monitoring of suppressor cell activity in vivo and their role in suppression of immune responses in melanoma patients is discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Werkmeister J,Phillips G,McCarthy W,Hersey Pdoi
10.1002/ijc.2910280103subject
Has Abstractpub_date
1981-07-15 00:00:00pages
11-15issue
1eissn
0020-7136issn
1097-0215journal_volume
28pub_type
杂志文章abstract::An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20821
更新日期:2005-05-10 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
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abstract::Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450123
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630205
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10403
更新日期:2002-06-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910190209
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abstract::To facilitate the use of multileaf collimator (MLC) in field shaping, we tested the hypothesis that the changes in the penumbra due to MLC replacing a Cerrobend block can be related to a change in the margin of the block. We also investigated if it is possible to estimate the effect of MLC replacing a block in terms o...
journal_title:International journal of cancer
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doi:10.1002/ijc.1038
更新日期:2001-12-20 00:00:00
abstract::The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21436
更新日期:2006-03-01 00:00:00
abstract::Commercial cow milk contains considerable amounts of estrogens. Our study assessed the effect of commercial low-fat milk on the development of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. Eighty 6-week-old female Sprague-Dawley rats received a single oral dose of 5 mg DMBA. Twenty-four hours l...
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更新日期:2004-07-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19990827)82:5<644::aid-ijc
更新日期:1999-08-27 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20535
更新日期:2005-01-01 00:00:00
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doi:10.1002/ijc.1401
更新日期:2001-09-01 00:00:00
abstract::Hybrid Capture 2 (HC2) Human Papillomavirus (HPV) DNA Test® is FDA approved and is a proven aid in detecting HPV infections of the cervix and as an aid in diagnosing, with cytology, cervical disease. A prospective feasibility study was conducted to determine if HC2 testing has utility when screening for high-grade ana...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.27431
更新日期:2012-10-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000101)85:1<40::aid-ijc7
更新日期:2000-01-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10391
更新日期:2002-06-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<54::aid-ijc1
更新日期:1999-01-05 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33352
更新日期:2020-10-22 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/(SICI)1097-0215(19960717)67:2<283::AID-IJC
更新日期:1996-07-17 00:00:00
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更新日期:2008-10-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1999-08-20 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
pub_type: 杂志文章
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1999-09-09 00:00:00
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journal_title:International journal of cancer
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更新日期:2012-09-01 00:00:00
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journal_title:International journal of cancer
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