Abstract:
:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean percentage of T gamma cells was significantly higher (p less than 0.001) in melanoma patients before surgery (21.8 +/- 5.4) compared to a group of age-matched controls (14.9 +/- 5.4). There was a tendency for the proportion of T gamma cells in patients to decrease after surgery, although the relative levels of T gamma were still significantly elevated (p less than 0.05) 6-8 weeks after surgery when compared to normal controls. The mean percentage of T and B cells in melanoma patients before and after surgery was comparable to that observed in normal controls. The degree of Con-A-induced suppression in patients increased significantly after surgery particularly at 6-8 weeks (p less than 0.02). No difference in con-A-induced suppressor cell activity was observed between melanoma patients and controls before or after surgery. An inverse relationship was found between the amount of Con-A-induced suppression and percentage of T gamma cells in melanoma patients before surgery. Similar associations were not apparent in patients after surgery or in normal control populations. The inverse correlation of Con-A-induced suppression with T gamma cell numbers suggests that the former may measure potential suppressor cell activity whereas the T gamma cells may indicate active suppressor cells. The significance of these findings for the monitoring of suppressor cell activity in vivo and their role in suppression of immune responses in melanoma patients is discussed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Werkmeister J,Phillips G,McCarthy W,Hersey Pdoi
10.1002/ijc.2910280103subject
Has Abstractpub_date
1981-07-15 00:00:00pages
11-15issue
1eissn
0020-7136issn
1097-0215journal_volume
28pub_type
杂志文章abstract::Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32090
更新日期:2019-09-15 00:00:00
abstract::Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420113
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360613
更新日期:1985-12-15 00:00:00
abstract::The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31740
更新日期:2018-12-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:1979-01-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
abstract::In mantle cell lymphoma (MCL), a blastoid variant with a striking tendency to harbor chromosome numbers in the tetraploid range has been identified. Centrosome aberrations have recently been implicated in the induction of aneuploidy in many human malignancies including MCL by malsegregation of chromosomes during anaph...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22404
更新日期:2007-04-15 00:00:00
abstract::It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<339::aid-ijc
更新日期:1998-01-30 00:00:00
abstract::In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2020-06-15 00:00:00
abstract::Histone H3 lysine 9 trimethylation (H3K9me3) is associated with transcriptional repression and regulated by histone lysine methyltransferases such as SUV39H1 and ESET. However, the functional roles of these enzymes in hepatocellular carcinoma (HCC) remain uncertain. In this study, we conducted loss-of-function assays ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28985
更新日期:2015-01-15 00:00:00
abstract::Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33486
更新日期:2021-01-27 00:00:00
abstract::We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30604
更新日期:2017-04-15 00:00:00
abstract::Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-r...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.25468
更新日期:2011-03-15 00:00:00
abstract::This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23499
更新日期:2008-07-15 00:00:00
abstract::Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010601)92:5<671::aid-ijc1240>3
更新日期:2001-06-01 00:00:00
abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23436
更新日期:2008-06-01 00:00:00
abstract::Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (tumor control/cure). The mechanisms that govern the outcome of radiot...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28558
更新日期:2014-05-15 00:00:00
abstract::B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22495
更新日期:2007-03-15 00:00:00
abstract::Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis and poorly understood aetiology. Consumption of hot beverages-a probable carcinogen to humans-is associated with increased ESCC risk in other settings and is habitually practiced in Keny...
journal_title:International journal of cancer
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doi:10.1002/ijc.32032
更新日期:2019-06-01 00:00:00
abstract::Intratumoural (i.t.) injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma. Here, biodistribution of [(125)I]IdUrd was evaluated 5 hr after i.t. injection in subcutaneous human glioblastoma xenografts LN229 after di...
journal_title:International journal of cancer
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更新日期:2004-05-20 00:00:00
abstract::The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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doi:10.1002/ijc.11700
更新日期:2004-04-10 00:00:00
abstract::Rapid tumor growth and metastasis are 2 major problems associated with treatment of malignant melanoma. Therefore, drugs that can intervene these processes are of clinical importance. Pentoxifylline (PTX), a methyl xanthine derivative, has been shown to inhibit B16F10 melanoma tumor growth and metastasis. We hypothesi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22843
更新日期:2007-10-01 00:00:00
abstract::The role of the mismatch repair (MMR) system in correcting base-base mismatches is well established; its involvement in the response to DNA double strand breaks, however, is less clear. We investigated the influence of the essential component of MMR, the hMLH1 protein, on the cellular response to DNA-double strand bre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24893
更新日期:2010-06-15 00:00:00
abstract::Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350414
更新日期:1985-04-15 00:00:00
abstract::Serum biomarkers are urgently needed for patient stratification and efficient treatment monitoring in pancreatic cancer (PC). Within a prospective diagnostic observation study, blood samples were obtained from 78 patients with advanced PC before and weekly during the course of palliative chemotherapy. Circulating nucl...
journal_title:International journal of cancer
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doi:10.1002/ijc.28294
更新日期:2013-12-01 00:00:00
abstract::In the context of opportunistic cervical cancer screening settings of low-and-middle-income countries, little is known about the benefits of high-risk human papillomavirus (hrHPV) testing on high-grade cervical abnormality detection among women with atypical squamous cells of undetermined significance (ASC-US) cytolog...
journal_title:International journal of cancer
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更新日期:2020-10-02 00:00:00
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journal_title:International journal of cancer
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更新日期:2014-09-01 00:00:00
abstract::Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...
journal_title:International journal of cancer
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更新日期:2005-12-10 00:00:00
abstract::The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...
journal_title:International journal of cancer
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更新日期:1989-12-15 00:00:00