Abstract:
:The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development of lung and liver metastases, which was associated with increased intratumoral accumulation of CD11b(+) Gr-1(+) TGF-β1(+) myeloid-derived suppressor cells (MDSCs) that expressed IL-13α1R, IL-13-producing Lin(-) Sca-1(+) ST2(+) innate lymphoid cells (ILCs) and CD4(+) Foxp3(+) ST2(+) IL-10(+) Tregs compared to untreated mice. Higher incidence of monocytic vs. granulocytic MDSCs and plasmocytoid vs. conventional dendritic cells (DCs) was present in mammary tumors of IL-33-treated mice. Intratumoral NKp46(+) NKG2D(+) and NKp46(+) FasL(+) cells were markedly reduced after IL-33 treatment, while phosphate-buffered saline-treated ST2-deficient mice had increased frequencies of these tumoricidal natural killer (NK) cells compared to untreated wild-type mice. IL-33 promoted intratumoral cell proliferation and neovascularization, which was attenuated in the absence of ST2. Tumor-bearing mice given IL-33 had increased percentages of splenic MDSCs, Lin(-) Sca-1(+) ILCs, IL-10-expressing CD11c(+) DCs and alternatively activated M2 macrophages and higher circulating levels of IL-10 and IL-13. A significantly reduced NK cell, but not CD8(+) T-cell cytotoxicity in IL-33-treated mice was observed and the mammary tumor progression was not affected when CD8(+) T cells were in vivo depleted. We show a previously unrecognized role for IL-33 in promoting breast cancer progression through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate antitumor immunity. Therefore, IL-33 may be considered as an important mediator in the regulation of breast cancer progression.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Jovanovic IP,Pejnovic NN,Radosavljevic GD,Pantic JM,Milovanovic MZ,Arsenijevic NN,Lukic MLdoi
10.1002/ijc.28481subject
Has Abstractpub_date
2014-04-01 00:00:00pages
1669-82issue
7eissn
0020-7136issn
1097-0215journal_volume
134pub_type
杂志文章abstract::We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31652
更新日期:2019-01-01 00:00:00
abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001001)88:1<58::aid-ijc9>3.0.c
更新日期:2000-10-01 00:00:00
abstract::PDT has been reported to induce cancer cell expression of cytokines, such as IL-6 and TNF-alpha, but it has been unclear whether cytokine expression by cancer cells is directly related to the antitumor effect of PDT. We treated Lewis lung carcinoma (LLC) cells with a new photosensitizer, mono-L-aspartyl chlorin e6 (NP...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1374
更新日期:2001-08-15 00:00:00
abstract::Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970904)72:5<821::aid-ijc
更新日期:1997-09-04 00:00:00
abstract::The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300203
更新日期:1982-08-15 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated lymphoepithelioma. The aim of this study was to characterize the homogeneity and distinctness of the T-cell repertoires within and between primary and metastatic NPCs. We used ultra-deep sequencing of the hypervariably rearranged antigen-binding ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31336
更新日期:2018-08-01 00:00:00
abstract::Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11413
更新日期:2003-11-10 00:00:00
abstract::We performed an integrated array comparative genomic hybridization (aCGH) and expression microarray analysis of 8 normal gastric tissues and 38 primary tumors, including 25 intestinal and 13 diffuse gastric adenocarcinomas to identify genes whose expression is deregulated in association with copy number alteration. Ou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23574
更新日期:2008-08-15 00:00:00
abstract::We characterized 8 human hepatocellular-carcinoma cell lines established from the primary tumors of Korean patients. All lines showed substrate adherence and one line from anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics of the original tumors from wh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620308
更新日期:1995-07-28 00:00:00
abstract::One hundred patients with Ph1-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph1 chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bone-marrow cells. Our study suggests that ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410609
更新日期:1988-06-15 00:00:00
abstract::The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450614
更新日期:1990-06-15 00:00:00
abstract::Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430538
更新日期:1989-05-15 00:00:00
abstract::Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most human breast cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000315)85:6<805::aid-ijc
更新日期:2000-03-15 00:00:00
abstract::In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33141
更新日期:2020-12-01 00:00:00
abstract::Evidence of the association between chronic inflammation and the risk of colorectal cancer (CRC) and other obesity-related cancers (OBRC) remains inconsistent, possibly due to a paucity of studies examining repeated measures of inflammation. In the Health ABC prospective study of 2,490 adults aged 70-79 years at basel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29868
更新日期:2016-03-01 00:00:00
abstract::Use of hormone replacement therapy (HRT) has been hypothesized to affect survival of epithelial ovarian cancer (EOC). We studied 5-year survival in patients with invasive EOC and borderline ovarian tumors (BOT) according to HRT use before and after diagnosis in a prospective nation-wide cohort study of 799 women diagn...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22218
更新日期:2006-12-15 00:00:00
abstract::Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is little direct evidence on how the genetic heterogeneity impacts on drug response profiles of the cancer cells. Our goal was to determine how genomic clonal evolution...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31815
更新日期:2019-03-15 00:00:00
abstract::Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.20917
更新日期:2005-07-01 00:00:00
abstract::Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols prepared from 244 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961220)69:6<475::AID-IJC
更新日期:1996-12-20 00:00:00
abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26365
更新日期:2012-07-01 00:00:00
abstract::Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all parti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23208
更新日期:2008-04-01 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25535
更新日期:2011-05-01 00:00:00
abstract::A considerable public concern about cancer risk from acrylamide-rich foods followed the announcement that high concentrations of acrylamide are found in fried potatoes and potato chips and, more generally, in starch-containing foods cooked at high temperatures. From a series of hospital-based case-control studies cond...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11118
更新日期:2003-07-01 00:00:00
abstract::Cells were isolated from post-radiation fibrosis biopsies of patients with recurrent breast carcinoma. These cells were identified as fibroblasts and compared with fibroblasts from normal breast tissues for their proliferative activities, chromosome number and for the presence of various components of the extracellula...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470512
更新日期:1991-03-12 00:00:00
abstract::A critical requirement for cancer vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a polyvalent melanoma vaccine to induce CD8+ T cell responses to the melanoma associated antigens MAGE-3 and Melan A/MART-1. Fifteen HLA-A2+ patients with resected malignant melanoma were im...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19970917)72:6<972::aid-ijc
更新日期:1997-09-17 00:00:00
abstract::DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10605
更新日期:2002-09-20 00:00:00
abstract::We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960301)65:5<671::AID-IJC
更新日期:1996-03-01 00:00:00
abstract::Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30677
更新日期:2017-06-01 00:00:00
abstract::The next-generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patient responses are variable, and survival benefit remains relatively small. Developing effective modality to improve MDV3100 efficacy is urgently needed. Recent eviden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28202
更新日期:2013-11-01 00:00:00
abstract::Intracellular thiols have been proposed as mediators of resistance to alkylating agents and cisplatin. As metallothionein is the predominant protein thiol, we examined its relationship to cisplatin resistance in human ovarian cancer cell lines. A human ovarian carcinoma cell line, A2780, derived from an untreated pati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450306
更新日期:1990-03-15 00:00:00