Lung cancer mortality associated with protracted low-dose occupational radiation exposures and smoking behaviors in U.S. radiologic technologists, 1983-2012.


:In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confounder. In a cohort of 106 068 U.S. radiologic technologists, we examined the association between estimated cumulative lung absorbed dose from occupational radiation exposure and lung cancer mortality. Poisson regression models, adjusted for attained age, sex, birth cohort, pack-years smoked and years since quitting smoking, were used to calculate linear excess relative risks (ERR) per 100 mGy, using time-dependent cumulative lung absorbed dose, lagged 10 years. Mean cumulative absorbed dose to the lung was 25 mGy (range: 0-810 mGy). During the 1983 to 2012 follow-up, 1090 participants died from lung cancer. Greater occupational radiation lung dose was not associated with lung cancer mortality overall (ERR per 100 mGy: -0.02, 95% CI: <0-0.13). However, significant dose-response relationships were observed for some subgroups, which might be false-positive results given the number of statistical tests performed. As observed in other studies of radiation and smoking, the interaction between radiation and smoking appeared to be sub-multiplicative with an ERR per 100 mGy of 0.41 (95% CI: 0.01-1.15) for those who smoked <20 pack-years and -0.03 (95% CI: <0-0.15) for those who smoked ≥20 pack-years. Our study provides some evidence that greater protracted radiation exposure in the low-dose range is positively associated with lung cancer mortality.


Int J Cancer


Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM




Has Abstract


2020-12-01 00:00:00












  • Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model.

    abstract::The light microscopic distinction between complex atypical hyperplasia (CAH) and invasive endometrioid carcinoma (UEC) on endometrial sampling is problematic and often has significant clinical implications. Using mouse models of endometrial tumorigenesis based on two of the most common molecular alterations found in p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang H,Joshi A,Iaconis L,Solomon GJ,Xiang Z,Verhage HG,Douglas W,Ronnett BM,Ellenson LH

    更新日期:2009-03-15 00:00:00

  • Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.

    abstract::Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in preventing lung can...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen GQ,Lin B,Dawson MI,Zhang XK

    更新日期:2002-05-10 00:00:00

  • A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer.

    abstract::Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatc...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Mesher D,Dove-Edwin I,Sasieni P,Vasen H,Bernstein I,Royer-Pokora B,Holinski-Feder E,Lalloo F,Evans DG,Forsberg A,Lindblom A,Thomas H

    更新日期:2014-02-15 00:00:00

  • Production and characterization of a mouse/human chimeric antibody directed against human neuroblastoma.

    abstract::Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Amstutz H,Rytz C,Novak-Hofer I,Spycher M,Schubiger PA,Blaser K,Morgenthaler JJ

    更新日期:1993-01-02 00:00:00

  • Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro.

    abstract::Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteoly...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hashim YZ,Rowland IR,McGlynn H,Servili M,Selvaggini R,Taticchi A,Esposto S,Montedoro G,Kaisalo L,Wähälä K,Gill CI

    更新日期:2008-02-01 00:00:00

  • Epigenetic determinants of ovarian clear cell carcinoma biology.

    abstract::Targeted approaches have revealed frequent epigenetic alterations in ovarian cancer, but the scope and relation of these changes to histologic subtype of disease is unclear. Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 non-CCC and four corresponding normal cell lines were generated...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamaguchi K,Huang Z,Matsumura N,Mandai M,Okamoto T,Baba T,Konishi I,Berchuck A,Murphy SK

    更新日期:2014-08-01 00:00:00

  • Studies of genetic transmission of mammary tumour virus by C3Hf mice.

    abstract::By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van Nie R,Verstraeten AA

    更新日期:1975-12-15 00:00:00

  • Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice.

    abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Haranaka K,Satomi N,Sakurai A

    更新日期:1984-08-15 00:00:00

  • In vitro transformation by avian erythroblastosis virus recruits cells of erythroid lineage with varying degree of differentiation.

    abstract::We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Therwath A,Scherrer K

    更新日期:1982-05-15 00:00:00

  • Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys).

    abstract::Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB

    更新日期:1986-10-15 00:00:00

  • Cervicovaginal human papillomavirus (HPV)-infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV-positive and HIV-negative women.

    abstract::Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

    更新日期:2012-09-15 00:00:00

  • Socioeconomic status and childhood acute lymphocytic leukemia incidence in São Paulo, Brazil.

    abstract::To investigate the association of childhood ALL and SES, we collected data on 507 children aged 0-14 years diagnosed with ALL between 1997 and 2002 from the population-based Cancer Registry of São Paulo, Brazil, covering 96 districts. Each child was assigned to an SES category based on the district of residence at dia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ribeiro KB,Buffler PA,Metayer C

    更新日期:2008-10-15 00:00:00

  • Association of IgA-anti-Fab autoantibodies with disease stage in head-and-neck cancer.

    abstract::Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Süsal C,Maier H,Lorenz K,Opelz G

    更新日期:1994-04-01 00:00:00

  • Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study.

    abstract::History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kasper JS,Liu Y,Giovannucci E

    更新日期:2009-03-15 00:00:00

  • A higher ctDNA fraction decreases survival in regorafenib-treated metastatic colorectal cancer patients. Results from the regorafenib's liquid biopsy translational biomarker phase II pilot study.

    abstract::The predictive effect of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) treatment is still highly discussed. The primary objective of our study was to investigate a possible prognostic/predictive value of ctDNA under regorafenib treatment. This prospective multicenter translational biomarker phase II pilot s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Unseld M,Belic J,Pierer K,Zhou Q,Moser T,Bauer R,Piringer G,Gerger A,Siebenhüner A,Speicher M,Heitzer E,Prager GW

    更新日期:2021-03-15 00:00:00

  • A prognostic classifier consisting of 17 circulating cytokines is a novel predictor of overall survival for metastatic colorectal cancer patients.

    abstract::We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemoth...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen ZY,He WZ,Peng LX,Jia WH,Guo RP,Xia LP,Qian CN

    更新日期:2015-02-01 00:00:00

  • Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling.

    abstract::The Glypican (GPC) family is a prototypical member of the cell-surface heparan sulfate proteoglycans (HSPGs). The HSPGs have been demonstrated to interact with growth factors, act as coreceptors and modulate growth factor activity. Here we show that based on oligonucleotide array analysis, GPC3 was upregulated in hepa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Midorikawa Y,Ishikawa S,Iwanari H,Imamura T,Sakamoto H,Miyazono K,Kodama T,Makuuchi M,Aburatani H

    更新日期:2003-02-10 00:00:00

  • Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.

    abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim YJ,Lee HJ,Kim TM,Eisinger-Mathason TS,Zhang AY,Schmidt B,Karl DL,Nakazawa MS,Park PJ,Simon MC,Yoon SS

    更新日期:2013-01-01 00:00:00

  • Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum: Identification of XAGE-1b as a dominant antigen and its immunogenicity in lung adenocarcinoma.

    abstract::By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ali Eldib AM,Ono T,Shimono M,Kaneko M,Nakagawa K,Tanaka R,Noguchi Y,Nakayama E

    更新日期:2004-02-10 00:00:00

  • Telomerase activity correlates with tumor aggressiveness and reflects therapy effect in breast cancer.

    abstract::Telomerase appears to be an important factor for the control of cellular proliferation capacity and for tumorigenesis. Enzyme activity is highly increased in almost all human tumors and distinguishes them from benign lesions. Besides its diagnostic value, telomerase activity appears to be associated with tumor progres...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hoos A,Hepp HH,Kaul S,Ahlert T,Bastert G,Wallwiener D

    更新日期:1998-02-20 00:00:00

  • In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma.

    abstract::2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dobos J,Tímár J,Bocsi J,Burián Z,Nagy K,Barna G,Peták I,Ladányi A

    更新日期:2004-12-10 00:00:00

  • Tobacco and occupation as risk factors in bladder cancer: a case-control study in southern Belgium.

    abstract::A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schifflers E,Jamart J,Renard V

    更新日期:1987-03-15 00:00:00

  • Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

    abstract::The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

    更新日期:2000-06-15 00:00:00

  • Syngeneic monoclonal antibodies directed against Rauscher virus-induced myeloid leukemic cells: isolation and characterization.

    abstract::Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Berends D,Rhijnsburger EH,van Gaalen JL,van Houwelingen G,Zondervan PE,de Both NJ

    更新日期:1988-07-15 00:00:00

  • Cytogenetic analysis of epithelial renal-cell tumors: relationship with a new histopathological classification.

    abstract::Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Störkel based on the ce...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van den Berg E,van der Hout AH,Oosterhuis JW,Störkel S,Dijkhuizen T,Dam A,Zweers HM,Mensink HJ,Buys CH,de Jong B

    更新日期:1993-09-09 00:00:00

  • Eurogin Roadmap 2015: How has HPV knowledge changed our practice: Vaccines.

    abstract::This review is one of two complementary reviews that have been prepared in the framework of the Eurogin Roadmap 2015 to evaluate how knowledge about HPV is changing practices in HPV infection and disease control through vaccination and screening. In this review of HPV vaccine knowledge, we present the most significant...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Brotherton JM,Jit M,Gravitt PE,Brisson M,Kreimer AR,Pai SI,Fakhry C,Monsonego J,Franceschi S

    更新日期:2016-08-01 00:00:00

  • Transformation of normal human melanocytes and non-malignant nevus cells by adenovirus 12-SV40 hybrid virus.

    abstract::Infection of normal human melanocyte and nevus cultures with an adenovirus 12-Simian Virus 40 hybrid virus (Ad12-SV40) produced transformed cells that expressed SV40-T antigen. The Ad12-SV40 cells exhibited rapid cell proliferation to high cell densities and efficient growth in soft agar, but none of 15 transformed me...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jambrosic J,Mancianti ML,Ricciardi R,Sela BA,Koprowski H,Herlyn M

    更新日期:1989-12-15 00:00:00

  • Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).

    abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vasen HF,Gruis NA,Frants RR,van Der Velden PA,Hille ET,Bergman W

    更新日期:2000-09-15 00:00:00

  • T lymphocytes infiltrating renal cell carcinoma have a reduced expression of transferrin receptor.

    abstract::T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

    更新日期:1994-08-01 00:00:00

  • Nevus density and melanoma risk in women: a pooled analysis to test the divergent pathway hypothesis.

    abstract::A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

    更新日期:2009-02-15 00:00:00