Abstract:
:Abnormal survivin expression has been reported to be involved in many types of cancer. A single-nucleotide polymorphism (SNP), C-31G, located in the promoter region of survivin reportedly may alter the mRNA level, while the significance of the nonsynonymous SNP A9194G in exon 4 has not yet been clarified. Here, the association between the two survivin SNPs and bladder cancer susceptibility and progression was investigated in 235 patients with bladder cancer and 346 healthy controls. Regarding the C-31G SNP, subjects with the CC genotype had a significantly higher risk of bladder cancer compared to those with the GG + CG genotype [odds ratio (OR) = 1.85, p = 0.001]. Regarding the A9194G SNP, the presence of the G allele was associated with a significantly reduced risk with a gene dosage effect (OR = 0.69, p = 0.002). Using the C-A haplotype as a reference, the G-G haplotype was associated with a significantly lower risk (OR = 0.11, p = 0.00006), indicating the cooperative effect of the two SNPs. Immunohistological evaluation of surgical specimens showed that cancer cells of the C-31G CC genotype had significantly higher nuclear survivin expression than those of the C-31G GG + CG genotype. With reverse transcriptase-polymerase chain reaction analysis, a significantly higher survivin mRNA expression level was observed in surgical specimens with an increase in the number of the C-31G C allele (p = 0.016). These results indicate that the two SNPs have a significant and cooperative influence on bladder cancer susceptibility.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kawata N,Tsuchiya N,Horikawa Y,Inoue T,Tsuruta H,Maita S,Satoh S,Mitobe Y,Narita S,Habuchi Tdoi
10.1002/ijc.25850subject
Has Abstractpub_date
2011-10-15 00:00:00pages
1872-80issue
8eissn
0020-7136issn
1097-0215journal_volume
129pub_type
杂志文章abstract::The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25726
更新日期:2011-08-01 00:00:00
abstract::B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22495
更新日期:2007-03-15 00:00:00
abstract::We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23589
更新日期:2008-10-01 00:00:00
abstract::To identify tumor-suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variant of the HELLS/SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Variant 1 was an alternatively spliced...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20407
更新日期:2004-10-20 00:00:00
abstract::Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180413
更新日期:1976-10-15 00:00:00
abstract::Molecular characterization has been extensively studied in serrated polyps but very little is known in serrated adenocarcinomas (SACs). We analyzed the incidence of KRAS, BRAF and PIK3CA mutations, microsatellite instability (MSI) status and loss of the DNA repair proteins MLH1, MSH2, MSH6 and MGMT in a series of 89 S...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27454
更新日期:2012-10-15 00:00:00
abstract::Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23412
更新日期:2008-06-01 00:00:00
abstract::Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570421
更新日期:1994-05-15 00:00:00
abstract::Infection of normal human melanocyte and nevus cultures with an adenovirus 12-Simian Virus 40 hybrid virus (Ad12-SV40) produced transformed cells that expressed SV40-T antigen. The Ad12-SV40 cells exhibited rapid cell proliferation to high cell densities and efficient growth in soft agar, but none of 15 transformed me...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440630
更新日期:1989-12-15 00:00:00
abstract::After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29833
更新日期:2016-02-15 00:00:00
abstract::There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28988
更新日期:2014-10-15 00:00:00
abstract::Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971127)73:5<707::aid-ijc
更新日期:1997-11-27 00:00:00
abstract::A series of 39 human brain tumors has been screened for the presence or absence of SV40-related T antigen by the direct and indirect immunoperoxidase methods. Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210104
更新日期:1978-01-15 00:00:00
abstract::Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22414
更新日期:2007-03-01 00:00:00
abstract::We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610212
更新日期:1995-04-10 00:00:00
abstract::Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<833::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960917)67:6<864::AID-IJC
更新日期:1996-09-17 00:00:00
abstract::We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570519
更新日期:1994-06-01 00:00:00
abstract::Development of targeted therapeutics is still at its early stage for hepatocellular carcinoma (HCC) due to the incomplete understanding of the confounding regulations at signaling pathway level. In this investigation, gene co-expression-based networking and integrative functional genomic modeling of HCC mRNA profiles ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30195
更新日期:2016-10-01 00:00:00
abstract::To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24392
更新日期:2009-08-01 00:00:00
abstract::Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32850
更新日期:2020-08-15 00:00:00
abstract::Telomerase plays a key role in carcinogenesis. It is activated in most immortal cell lines and human cancers, including cutaneous melanoma (CM). Increased cell proliferation and deregulation of the cell cycle occur in human cancers. Links between telomerase activity (TA), cell proliferation, cell death and expression ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370207
更新日期:1986-02-15 00:00:00
abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22126
更新日期:2006-12-01 00:00:00
abstract::The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case-control and cohort studies. In the case-control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were ant...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28753
更新日期:2014-09-01 00:00:00
abstract::Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::In this prospective study, the relationship between energy and fat consumption and the risk of breast cancer was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age attended a health screening. The attendees were given a food-frequency questionnaire to be completed at home, and this was retu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630104
更新日期:1995-09-27 00:00:00
abstract::Recently, several studies have showed that FAS (rs2234767, rs1800682) and FASL (rs763110) functional single nucleotide polymorphisms (SNPs) were associated with the risk of various cancers. However, the association between cervical cancer risk and the three SNPs above remained inconclusive. In this work, we performed ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30490
更新日期:2017-02-15 00:00:00
abstract::Actin, a highly conserved protein comprising cell stress fibers and other cellular structures, is found in both the cytoplasm and nucleus of cells and responds to both epigenetic signals and altered gene expression occurring during tumorigenesis. We have previously shown that changes in the cytoplasmic F- and G-actin ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970207)70:4<423::aid-ijc
更新日期:1997-02-07 00:00:00
abstract::Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170502
更新日期:1976-05-15 00:00:00