Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients.

Abstract:

:Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical studies in mice and rabbits, recombinant baculovirus-derived GA733-2E antigen was superior to anti-idiotypic antibodies at modulating specific immune responses. Our aim was to evaluate the immunogenicity and potential toxicity of alum-precipitated GA733-2E in a phase I trial in patients with resected CRC or pancreatic cancer. Six patients with advanced pancreatic carcinoma and 6 with CRC Dukes' stage A, B or C received between 4 and 7 doses of alum-precipitated GA733-2E at 50, 200 or 800 microg/dose at monthly intervals. Antibody binding to GA733-2E or antigen-positive CRC cells was determined, as were antigen-specific proliferative, cytolytic T-lymphocyte and delayed-type hypersensitivity responses. Six of the 12 patients developed antigen-specific humoral immune responses after immunotherapy, and 8 developed cellular immune responses. The overall immune response rate, including patients with humoral and/or cellular immune responses, was 83%. Median overall survival of the CRC and pancreatic cancer patients was 39.8 and 11.2 months, respectively. Following 18 years of single-epitope targeting of the GA733 antigen, immunization of patients against multiple epitopes of the antigen frequently induces an immune response in the absence of significant toxicity, despite relatively widespread expression of this antigen on normal epithelial cells.

journal_name

Int J Cancer

authors

Staib L,Birebent B,Somasundaram R,Purev E,Braumüller H,Leeser C,Küttner N,Li W,Zhu D,Diao J,Wunner W,Speicher D,Beger HG,Song H,Herlyn D

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

79-87

issue

1

eissn

0020-7136

issn

1097-0215

pii

10.1002/1097-0215(20010401)92:1<79::AID-IJC1164>3.

journal_volume

92

pub_type

临床试验,杂志文章
  • The evolving epidemic of breast cancer in sub-Saharan Africa: Results from the African Cancer Registry Network.

    abstract::Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in premenopausal and postmenopausal women is unknown in most African countries. We used data from the African Cancer Regis...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33014

    authors: Joko-Fru WY,Jedy-Agba E,Korir A,Ogunbiyi O,Dzamalala CP,Chokunonga E,Wabinga H,Manraj S,Finesse A,Somdyala N,Liu B,McGale P,Jemal A,Bray F,Parkin DM

    更新日期:2020-10-15 00:00:00

  • Repair of DNA damage induced by accelerated heavy ions--a mini review.

    abstract::Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.26445

    authors: Okayasu R

    更新日期:2012-03-01 00:00:00

  • Humoral cytotoxicity in melanoma patients and its correlation with the extent and course of the disease.

    abstract::Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910160504

    authors: Canevari S,Fossati G,Della Porta G,Balzarini GP

    更新日期:1975-11-15 00:00:00

  • Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination.

    abstract::NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.23810

    authors: Wada H,Sato E,Uenaka A,Isobe M,Kawabata R,Nakamura Y,Iwae S,Yonezawa K,Yamasaki M,Miyata H,Doki Y,Shiku H,Jungbluth AA,Ritter G,Murphy R,Hoffman EW,Old LJ,Monden M,Nakayama E

    更新日期:2008-11-15 00:00:00

  • Cost of decentralized CAR T-cell production in an academic nonprofit setting.

    abstract::Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.33156

    authors: Ran T,Eichmüller SB,Schmidt P,Schlander M

    更新日期:2020-12-15 00:00:00

  • Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.

    abstract::We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was determined using the MTS assay. To investigate the inhibitory effects of sunitinib in vivo, we establ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26034

    authors: Maita S,Yuasa T,Tsuchiya N,Mitobe Y,Narita S,Horikawa Y,Hatake K,Fukui I,Kimura S,Maekawa T,Habuchi T

    更新日期:2012-02-01 00:00:00

  • Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in Epstein-Barr-virus-positive nasopharyngeal carcinoma cells.

    abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910500605

    authors: Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

    更新日期:1992-04-01 00:00:00

  • Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study.

    abstract::Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29463

    authors: Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

    更新日期:2015-08-15 00:00:00

  • Breast cancer and microbial cancer incidence in female populations around the world: a surprising hyperbolic association.

    abstract::Current literature on cancer epidemiology typically discusses etiology of cancer by cancer type. Risks of different cancer types are, however, correlated at population level and may provide etiological clues. We showed previously an unexpected very high positive correlation between breast cancer (BC) and young-adult H...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.23595

    authors: Savu A,Potter J,Li S,Yasui Y

    更新日期:2008-09-01 00:00:00

  • A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.

    abstract::Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26104

    authors: Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

    更新日期:2012-03-01 00:00:00

  • Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer pathogenesis.

    abstract::In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs a...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30681

    authors: Das Ghosh D,Mukhopadhyay I,Bhattacharya A,Roy Chowdhury R,Mandal NR,Roy S,Sengupta S

    更新日期:2017-06-01 00:00:00

  • Long-term risk of colorectal cancer after negative colonoscopy in a Danish gFOBT screening cohort.

    abstract::Faecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all screen positive persons have negative colonoscopy, but consensus is lacking on how these persons should be followed up. Health authorities in Denmark and The Netherlands recommend suspen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30756

    authors: Bjerrum A,Andersen O,Fischer A,Lindebjerg J,Lynge E

    更新日期:2017-08-01 00:00:00

  • Expression of neuronal src mRNA as a favorable marker and inverse correlation to N-myc gene amplification in human neuroblastomas.

    abstract::Neuron-specific src mRNA, which is expressed in human brain tissue by alternative splicing, is associated with neural differentiation. Neuronal c-srcNI expression may be associated with the ability of neuroblastomas to mature; furthermore, c-srcN2 mRNA is induced in chemically differentiated neuroblastoma cells in vit...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910580607

    authors: Matsunaga T,Shirasawa H,Tanabe M,Ohnuma N,Kawamura K,Etoh T,Takahashi H,Simizu B

    更新日期:1994-09-15 00:00:00

  • The value of histoquantitative measurements in prognostic assessment of renal adenocarcinoma.

    abstract::In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910550405

    authors: Eskelinen M,Lipponen P,Aitto-Oja L,Hall O,Syrjänen K

    更新日期:1993-10-21 00:00:00

  • Effects of recombinant human tumor necrosis factor-alpha on the surface phenotype and the growth of human malignant glioma cell lines.

    abstract::Human malignant glioma cell lines and clones were incubated with various concentrations of recombinant human TNF-alpha, either alone or in combination with recombinant human IFN-gamma. The surface expression of HLA-ABC (class I) antigens and beta 2-microglobulin, was significantly enhanced by TNF-alpha alone on every ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910420525

    authors: Zuber P,Accolla RS,Carrel S,Diserens AC,de Tribolet N

    更新日期:1988-11-15 00:00:00

  • Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients.

    abstract::In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910490406

    authors: Gatteschi B,Costantini M,Bruzzi P,Merlo F,Torcoli R,Nicolo G

    更新日期:1991-10-21 00:00:00

  • Innate lymphoid cells involve in tumorigenesis.

    abstract::Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.29443

    authors: Tian Z,van Velkinburgh JC,Wu Y,Ni B

    更新日期:2016-01-01 00:00:00

  • Effect of epidermal growth factor on clonogenic growth of primary human tumor cells.

    abstract::The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910300611

    authors: Pathak MA,Matrisian LM,Magun BE,Salmon SE

    更新日期:1982-12-15 00:00:00

  • Tumor-platelet interaction in solid tumors.

    abstract::Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.27441

    authors: Buergy D,Wenz F,Groden C,Brockmann MA

    更新日期:2012-06-15 00:00:00

  • Melanoma progression-associated glycoprotein MUC18/MCAM mediates homotypic cell adhesion through interaction with a heterophilic ligand.

    abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19971127)73:5<769::aid-ijc

    authors: Johnson JP,Bar-Eli M,Jansen B,Markhof E

    更新日期:1997-11-27 00:00:00

  • Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.

    abstract::We applied a strategy that utilized a combination of systematic gene expression analysis with various tissues and immunological detection with sera from melanoma patients to identify melanoma antigens expressed preferentially in melanoma and melanocytes. We selected 101 genes by comparing cDNA profiles obtained by Gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20735

    authors: Inozume T,Matsuzaki Y,Kurihara S,Fujita T,Yamamoto A,Aburatani H,Shimada S,Kawakami Y

    更新日期:2005-03-20 00:00:00

  • HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.

    abstract::mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast cancer. The feedback ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28880

    authors: Chen SM,Guo CL,Shi JJ,Xu YC,Chen Y,Shen YY,Su Y,Ding J,Meng LH

    更新日期:2014-11-15 00:00:00

  • Geospatial barriers to health care access for breast cancer diagnosis in sub-Saharan African settings: the African Breast Cancer - Disparities in Outcomes (ABC-DO) Cohort Study.

    abstract::We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33400

    authors: Togawa K,Anderson BO,Foerster M,Galukande M,Zietsman A,Pontac J,Anele A,Adisa C,Parham G,Pinder LF,McKenzie F,Schüz J,Dos-Santos-Silva I,McCormack V

    更新日期:2020-11-16 00:00:00

  • Screening for familial and hereditary prostate cancer.

    abstract::Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.29949

    authors: Lynch HT,Kosoko-Lasaki O,Leslie SW,Rendell M,Shaw T,Snyder C,D'Amico AV,Buxbaum S,Isaacs WB,Loeb S,Moul JW,Powell I

    更新日期:2016-06-01 00:00:00

  • Differential expression of cell adhesion genes: implications for drug resistance.

    abstract::It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.20671

    authors: Stein WD,Litman T,Fojo T,Bates SE

    更新日期:2005-03-01 00:00:00

  • Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma.

    abstract::As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides. Its polymorphisms may affect the TS gene expression and the susceptibility for Fluoropyrimidine (FU)-based chemotherapies. In this study, we assessed the relationship between the TS genotypes and clinical...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25096

    authors: Schwarzenbach H,Goekkurt E,Pantel K,Aust DE,Stoehlmacher J

    更新日期:2010-08-15 00:00:00

  • Morphological and microbiological signs of endogenous C-virus in human oocytes.

    abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910280504

    authors: Larsson E,Nilsson BO,Sundström P,Widéhn S

    更新日期:1981-11-15 00:00:00

  • Increased levels of 5-fluorouracil-induced DNA lesions in Bloom's syndrome.

    abstract::In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450321

    authors: Lönn U,Lönn S,Nylen U,Winblad G

    更新日期:1990-03-15 00:00:00

  • Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.

    abstract::A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.25432

    authors: Shima K,Nosho K,Baba Y,Cantor M,Meyerhardt JA,Giovannucci EL,Fuchs CS,Ogino S

    更新日期:2011-03-01 00:00:00

  • Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

    abstract::Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29583

    authors: Schneider V,Zhang L,Rojewski M,Fekete N,Schrezenmeier H,Erle A,Bullinger L,Hofmann S,Götz M,Döhner K,Ihme S,Döhner H,Buske C,Feuring-Buske M,Greiner J

    更新日期:2015-11-01 00:00:00