Abstract:
:The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF-IR neutralizing antibody confirmed that the IGF-IR was essential to support growth of neuroblastoma cell lines. The expression levels of the IGF-IR in individual neuroblastoma cell lines did not correlate with the sensitivities to NVP-AEW541, while coexpression of the IGF-IR and the insulin receptor (IR) correlated with lower sensitivity to the inhibitor in some cell lines. Intriguingly, high levels of activation of Akt/protein kinase B (PKB) and phosphorylation of the ribosomal S6 protein were observed in neuroblastoma cell lines with decreased sensitivities to NVP-AEW541. Inhibition of Akt/PKB activity restored the sensitivity of neuroblastoma cells to the IGF-IR inhibitor. Transfection of neuroblastoma cells with activated Akt or ribosomal protein S6 kinase (S6K) decreased the sensitivity of the cells to NVP-AEW541. IGF-I-stimulated proliferation of neuroblastoma cell lines was completely blocked by NVP-AEW541, or by a combination of an inhibitor of phosphoinositide 3-kinase and rapamycin. In addition to its antiproliferative effects, NVP-AEW541 sensitized neuroblastoma cells to cisplatin-induced apoptosis. Together, our data demonstrate that NVP-AEW541 in combination with Akt/PKB inhibitors or chemotherapeutic agents may represent a novel approach to target human neuroblastoma cell proliferation.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro Adoi
10.1002/ijc.22126subject
Has Abstractpub_date
2006-12-01 00:00:00pages
2527-38issue
11eissn
0020-7136issn
1097-0215journal_volume
119pub_type
杂志文章abstract::Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20845
更新日期:2005-05-20 00:00:00
abstract::Monoclonal antibody (MAb) B72.3 has been previously shown, by in vitro assays, to have a high degree of specificity for carcinomas of the colon, ovary and breast versus normal adult tissues. B72.3 IgG was labelled with 131I and injected i.v. into 20 patients with known or suspected colorectal cancer. All patients subs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390110
更新日期:1987-01-15 00:00:00
abstract::Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31152
更新日期:2018-04-01 00:00:00
abstract::In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24869
更新日期:2010-04-01 00:00:00
abstract::Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
doi:10.1002/ijc.20917
更新日期:2005-07-01 00:00:00
abstract::Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450410
更新日期:1990-04-15 00:00:00
abstract::The alpha 5 beta 1 integrin (CD49e/CD29), a heterodimeric membrane protein, is the "classical" fibronectin receptor on many cell types. During B-cell ontogeny, expression of the alpha 5-subunit is developmentally regulated. The alpha 5 beta 1 is decisive for migration on fibronectin substrate and very likely cooperate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600623
更新日期:1995-03-16 00:00:00
abstract::Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30499
更新日期:2017-02-15 00:00:00
abstract::Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10771
更新日期:2002-12-20 00:00:00
abstract::Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33209
更新日期:2021-01-15 00:00:00
abstract::The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1352
更新日期:2001-08-01 00:00:00
abstract::Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23242
更新日期:2008-03-15 00:00:00
abstract::Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970611)71:6<978::aid-ijc
更新日期:1997-06-11 00:00:00
abstract::Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32384
更新日期:2019-12-15 00:00:00
abstract::Risk of adult lymphoid malignancy is associated with recent adiposity. Some have reported apparent associations with adiposity in childhood or early adulthood, but whether these associations are independent of recent adiposity is unknown. Birth weight, body size at age 10 years, clothes size at age 20 years, and recen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30044
更新日期:2016-07-01 00:00:00
abstract::p16(INK4a), a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high-risk human papilloma virus (HPV). In immunostaining studies, p16(INK4a) has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. To evaluate its potential...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22612
更新日期:2007-06-01 00:00:00
abstract::We have previously described an inverse relationship between Cu-Zn superoxide dismutase (SOD) activity and invasiveness of a clone of human tongue cancer cells. In these cells, suppression of Cu-Zn SOD activity by transfection with anti-sense cDNA enhanced motility in vitro. The present studies were undertaken to dete...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971009)73:2<187::aid-ijc
更新日期:1997-10-09 00:00:00
abstract::The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360208
更新日期:1985-08-15 00:00:00
abstract::Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31270
更新日期:2018-11-01 00:00:00
abstract::Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by activation of protein kinase C (PKC). This cell line, VACO 10MS, grows as multicell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990129)80:3<455::aid-ijc
更新日期:1999-01-29 00:00:00
abstract::LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20881
更新日期:2005-07-01 00:00:00
abstract::A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430603
更新日期:1989-06-15 00:00:00
abstract::Retinoids are a group of vitamin A analogues that have shown promise as chemopreventive and therapeutic agents in many types of malignancy and have been entered in clinical trials with some successful results. To better understand the mechanism that mediates retinoid action and the anti-proliferative effects, we treat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970117)70:2<194::aid-ijc
更新日期:1997-01-17 00:00:00
abstract::KLF5 is a transcription factor that plays important roles in multiple physical and pathological processes, including cell growth, cell cycle regulation, and angiogenesis. To better characterize KLF5 function in bladder carcinogenesis, we established stable TSU-Pr1 cell clones expressing different levels of KLF5. These...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21533
更新日期:2006-03-15 00:00:00
abstract::By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390212
更新日期:1987-02-15 00:00:00
abstract::Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lym...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530523
更新日期:1993-03-12 00:00:00
abstract::Oncostatin M is a leukocyte product that has been reported to have anti-proliferative effects directly on melanoma and other cancer cell lines in vitro. However, its function(s) in cancers in vivo appears complex and its roles in cancer growth in lungs are unknown. Here, we show that OSM promotes marked growth of tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29055
更新日期:2015-02-15 00:00:00
abstract::The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430606
更新日期:1989-06-15 00:00:00
abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530520
更新日期:1993-03-12 00:00:00