Abstract:
:Conventionally bred rats possess in their sera an NA which has a cytotoxic effect on a tumor cell line (KMT-17) derived from a fibrosarcoma induced by 3-methylcholanthrene and which can be absorbed by normal rat tissues. We have succeeded in purifying a glycosphingolipid as an antigen reactive to NA. GSLs isolated from the tumor cells were separated into neutral and acidic fractions. The former fraction was judged to be antigenic as detected by its capacity to absorb NA. The antigenic fraction was further separated into 7 fractions (Frs. A to G) by silicic acid chromatography. The antigenic activity was detected in only Frs.D and E, although Fr.D was a more potent antigen than Fr.E. Chemical and immunochemical analyses showed that both fractions are composed of lactoneotetraglycosyl ceramide (paragloboside), Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(beta 1-1)ceramide, and that the more active GSL, Fr.D, contains larger amounts of long fatty-acid chains. Inhibition studies using disaccharides and monosaccharides indicated that a N-acetyllactosamine moiety, Gal(beta 1-4)GlcNAc, of the GSL is a specific site of NA. These results suggest that paragloboside is an NA antigen and that a sugar chain portion of this GSL is required for defining specificity while the ceramide portion plays a role in potentiating the antigenicity of this GSL antigen for NA.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Takimoto M,Suzuki E,Naiki M,Itaya T,Takeichi N,Hosokawa M,Kobayashi Hdoi
10.1002/ijc.2910360613subject
Has Abstractpub_date
1985-12-15 00:00:00pages
695-700issue
6eissn
0020-7136issn
1097-0215journal_volume
36pub_type
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2016-04-15 00:00:00
abstract::IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzyme-linked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy age-matched controls. Significantly greater binding (p<0.01) was found in breast-cancer-derived sera than in the other ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250606
更新日期:1980-06-15 00:00:00
abstract::An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210614
更新日期:1978-06-15 00:00:00
abstract::Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23086
更新日期:2008-02-01 00:00:00
abstract::Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580104
更新日期:1994-07-01 00:00:00
abstract::The aim of this register-based follow-up study was to evaluate the long-term cumulative incidence of second primary tumors (SPT) among survivors of hereditary retinoblastoma, with special interest for the incidence of pineoblastoma in retinoblastoma patients born after 1970. The Dutch Retinoblastoma Register was compl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960807)67:4<515::AID-IJC
更新日期:1996-08-07 00:00:00
abstract::We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980729)77:3<386::aid-ijc
更新日期:1998-07-29 00:00:00
abstract::Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapy-refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumoral expression of key signaling mo...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
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更新日期:2005-01-01 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
更新日期:1980-11-15 00:00:00
abstract::We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590412
更新日期:1994-11-15 00:00:00
abstract::Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29882
更新日期:2016-03-15 00:00:00
abstract::Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22772
更新日期:2007-09-01 00:00:00
abstract::Chen, B., Liu, X., Savell, V.H., Dilday, B.R., Johnson, M.W., Jenkins, J.J., and Parham, D.M., Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999). Due to a printer's error, the bottom of Figure 3 was cut off after the proofs had been approved by the author. The correct fi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991210)83:6<874::aid-ijc
更新日期:1999-12-10 00:00:00
abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32424
更新日期:2020-01-15 00:00:00
abstract::Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470303
更新日期:1991-02-01 00:00:00
abstract::The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24012
更新日期:2009-02-01 00:00:00
abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32091
更新日期:2019-07-01 00:00:00
abstract::In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30681
更新日期:2017-06-01 00:00:00
abstract::To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31962
更新日期:2019-05-15 00:00:00
abstract::In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
abstract::Little research has been conducted on the long-term value of human papillomavirus (HPV) testing after conization. We investigated whether cytology adds to the value of a negative HPV test for long-term prediction of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). In addition, we compared risk of CIN2+ fol...
journal_title:International journal of cancer
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更新日期:2015-12-15 00:00:00
abstract::Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980529)76:5<709::aid-ijc
更新日期:1998-05-29 00:00:00
abstract::We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At the highest dose of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980703)77:1<101::aid-ijc
更新日期:1998-07-03 00:00:00
abstract::Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10258
更新日期:2002-04-20 00:00:00
abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28199
更新日期:2013-10-15 00:00:00
abstract::In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Frameshift mutations,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980619)79:3<273::aid-ijc
更新日期:1998-06-19 00:00:00
abstract::Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...
journal_title:International journal of cancer
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更新日期:2015-03-01 00:00:00
abstract::Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310516
更新日期:1983-05-15 00:00:00
abstract::BALB/c peritoneal plasmacytomas induced by a variety of agents are invariably associated with a c-myc translocation. In contrast, naturally arising bone marrow plasma cell tumors in C57BL/KaLwRij mice lack this translocation. This difference has led to the suggestion that these are 2 fundamentally different plasma cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970904)72:5<892::aid-ijc
更新日期:1997-09-04 00:00:00
abstract::The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28559
更新日期:2014-05-15 00:00:00