Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats.

abstract：:In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...

journal_title：International journal of cancer

authors： Thorne JL,Campbell MJ

更新日期：2015-10-01 00:00:00

abstract：:Laser scanning confocal microscopy has been used to follow the uptake and efflux of the 2-fluoroglycoside of doxorubicin, ME2303, in live cultures of the human ovarian cancer cell line A2780 and its doxorubicin-resistant variant A2780AD. Our methods combine confocal laser scanning microscopy and image analysis to exam...

journal_title：International journal of cancer

authors： Huxham IM,Barlow AL,Lewis AD,Plumb J,Mairs RJ,Gaze MN,Workman P

更新日期：1994-10-01 00:00:00

abstract：:Spleen cells from BALB/c mice bearing syngeneic, methylcholanthrene-induced sarcomas were cultured in vitro. In agreement with previous observations, two tumor-specific activities could be demonstrated in the culture supernatants: the supernatants suppressed (blocked) specific lymph-node cell-mediated cytotoxicity dir...

journal_title：International journal of cancer

authors： Nelson K,Pollack SB,Hellström KE

更新日期：1975-10-15 00:00:00

abstract：:Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies...

journal_title：International journal of cancer

authors： Mechtersheimer G,Staudter M,Majdic O,Dörken B,Moldenhauer G,Möller P

更新日期：1990-11-15 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:The neural crest gives rise to a variety of tissues, including peripheral neurons, Schwann cells, melanocytes and ectomesenchymal cells, which include the smooth-muscle cells of large arteries. Cell lines derived from neuroblastoma (a neural-crest tumor) exhibit at least 2 distinct morphological cell types, a neurobla...

journal_title：International journal of cancer

authors： Sugimoto T,Ueyama H,Hosoi H,Inazawa J,Kato T,Kemshead JT,Reynolds CP,Gown AM,Mine H,Sawada T

更新日期：1991-05-10 00:00:00

abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

journal_title：International journal of cancer

authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

更新日期：2000-03-01 00:00:00

abstract：:Incidence data pertaining to more than 250,000 cancer cases diagnosed during the years 1972-1989 among residents of urban Shanghai, China, were analyzed to determine the relative importance of the various malignancies and to discover changes over time. In the most recent 3-year period, lung cancer was the most frequen...

journal_title：International journal of cancer

authors： Jin F,Devesa SS,Zheng W,Blot WJ,Fraumeni JF Jr,Gao YT

更新日期：1993-03-12 00:00:00

abstract：:Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...

journal_title：International journal of cancer

authors： Furihata M,Yamasaki I,Ohtsuki Y,Sonobe H,Morioka M,Yamamoto A,Terao N,Kuwahara M,Fujisaki N

更新日期：1995-10-20 00:00:00

abstract：:B700 and B50 are melanoma-specific antigens originally isolated from B16 murine melanoma. B700, which elicits a strong tumor rejection response, is present on all murine melanomas tested to date. We now demonstrate the presence of B50 in the other murine melanomas and find that the 2 molecules are non-covalently compl...

journal_title：International journal of cancer

authors： Gersten DM,Williams LJ,Moody D,Montague PM,Law LW,Hearing VJ

更新日期：1989-03-15 00:00:00

abstract：:Exosomal noncoding RNAs (ncRNAs) have unique expression profiles reflecting the characteristics of a tumor, and their role in tumor progression and metastasis is emerging. However, the significance of circulating exosomal ncRNAs in the prognosis of hepatocellular carcinoma (HCC) remains to be elucidated. We therefore ...

journal_title：International journal of cancer

authors： Lee YR,Kim G,Tak WY,Jang SY,Kweon YO,Park JG,Lee HW,Han YS,Chun JM,Park SY,Hur K

更新日期：2019-03-15 00:00:00

abstract：:It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 ...

journal_title：International journal of cancer

authors： Zeleniuch-Jacquotte A,Lundin E,Micheli A,Koenig KL,Lenner P,Muti P,Shore RE,Johansson I,Krogh V,Lukanova A,Stattin P,Afanasyeva Y,Rinaldi S,Arslan AA,Kaaks R,Berrino F,Hallmans G,Toniolo P,Adlercreutz H

更新日期：2006-11-15 00:00:00

abstract：:Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

journal_title：International journal of cancer

authors： Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

更新日期：2005-08-10 00:00:00

abstract：:A reanalysis of the Women's Health Initiative (WHI) randomized clinical trial found a significant interaction between supplementation with vitamin D/calcium and estrogen therapy and the risk of colorectal cancer risk, with reduced risks from supplementation limited to the placebo arms of the estrogen trials. To explor...

journal_title：International journal of cancer

authors： Freedman DM,Rajaraman P,Fuhrman B,Hoffbeck R,Alexander BH

更新日期：2010-04-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) receptors constitute a family of transmembrane proteins that bind TGF-beta ligands. In this study we assessed the growth responsiveness to TGF-beta 1 in pancreatic cancer cell lines and characterized the levels of expression of TGF-beta receptors in these cell lines and in hu...

journal_title：International journal of cancer

authors： Baldwin RL,Friess H,Yokoyama M,Lopez ME,Kobrin MS,Büchler MW,Korc M

更新日期：1996-07-17 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...

journal_title：International journal of cancer

authors： Pukkala E,Kyyrönen P,Sankila R,Holli K

更新日期：2002-07-20 00:00:00

abstract：:Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...

journal_title：International journal of cancer

authors： Fiegl H,Windbichler G,Mueller-Holzner E,Goebel G,Lechner M,Jacobs IJ,Widschwendter M

更新日期：2008-08-01 00:00:00

abstract：:Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...

journal_title：International journal of cancer

authors： Guenther A,Gordon S,Tiemann M,Burger R,Bakker F,Green JR,Baum W,Roelofs AJ,Rogers MJ,Gramatzki M

更新日期：2010-01-01 00:00:00

abstract：:The knowledge that cervical neoplasia are caused by human papillomavirus (HPV) infection has led to the evaluation of its role in screening. We evaluated the accuracy of HPV testing by Hybrid capture II (HC II) method in detecting cervical intraepithelial neoplasia grade 2 and 3 (CIN 2 and 3) lesions in 4 cross-sectio...

journal_title：International journal of cancer

authors： Sankaranarayanan R,Chatterji R,Shastri SS,Wesley RS,Basu P,Mahe C,Muwonge R,Seigneurin D,Somanathan T,Roy C,Kelkar R,Chinoy R,Dinshaw K,Mandal R,Amin G,Goswami S,Pal S,Patil S,Dhakad N,Frappart L,Fontaniere B

更新日期：2004-11-01 00:00:00

abstract：:An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...

journal_title：International journal of cancer

authors： Ruoslahti E,Sjögren HO

更新日期：1976-09-15 00:00:00

abstract：:The prevalence of adult T-cell-leukemia virus (ATLV) infection was examined in Japanese monkeys living naturally in various parts of Japan and in other species of non-human primates imported into and kept in Japan. Sera of 2,650 Japanese monkeys from 41 troops throughout Japan were tested. High incidences of anti-ATLV...

journal_title：International journal of cancer

authors： Hayami M,Komuro A,Nozawa K,Shotake T,Ishikawa K,Yamamoto K,Ishida T,Honjo S,Hinuma Y

更新日期：1984-02-15 00:00:00

abstract：:One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-R...

journal_title：International journal of cancer

authors： Lee KW,Kim MS,Kang NJ,Kim DH,Surh YJ,Lee HJ,Moon A

更新日期：2006-10-15 00:00:00

abstract：:Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder...

journal_title：International journal of cancer

authors： Weikert S,Christoph F,Schrader M,Krause H,Miller K,Müller M

更新日期：2005-08-10 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

journal_title：International journal of cancer

authors： Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

更新日期：2007-02-01 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...

journal_title：International journal of cancer

authors： Tur MK,Huhn M,Jost E,Thepen T,Brümmendorf TH,Barth S

更新日期：2011-09-01 00:00:00

abstract：:Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n ...

journal_title：International journal of cancer

authors： Messerschmidt C,Obermayer B,Klinghammer K,Ochsenreither S,Treue D,Stenzinger A,Glimm H,Fröhling S,Kindler T,Brandts CH,Schulze-Osthoff K,Weichert W,Tinhofer I,Klauschen F,Keilholz U,Beule D,Rieke DT

更新日期：2020-10-15 00:00:00

abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

journal_title：International journal of cancer

authors： Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

更新日期：2000-10-01 00:00:00

abstract：:9-cis-Retinoic acid (9cRA) and 1alpha,25-dihydroxyvitamin D3 (1,25D) show promise as potential chemopreventive agents. We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)-induced lung carcinogenesis in A/J mice. A/J mice (n=14/group) were treated with 9cRA (7.5, 15, or...

journal_title：International journal of cancer

authors： Mernitz H,Smith DE,Wood RJ,Russell RM,Wang XD

更新日期：2007-04-01 00:00:00