Role of multileaf collimator in replacing shielding blocks in radiation therapy.

Abstract:

:To facilitate the use of multileaf collimator (MLC) in field shaping, we tested the hypothesis that the changes in the penumbra due to MLC replacing a Cerrobend block can be related to a change in the margin of the block. We also investigated if it is possible to estimate the effect of MLC replacing a block in terms of a change in the block margin. Calculations were performed for a single field as well as a multiple field setup. For the single field setup, blocks with equal areas were drawn at the four corners of a 16 x 20 cm(2) field at angles of 20 degrees, 40 degrees, 60 degrees, and 80 degrees with the horizontal axis. The blocks were then replaced with MLC leaves. For 6 MV x-rays, dose profiles in the penumbra regions of the blocks at 5- and 10-cm depths were compared with those obtained with the corresponding MLC setup. For multiple fields, the same sets of blocks were set up on the anterio-posterior (AP-PA) pair of a four-field setup. The margins of the blocks were increased (i.e., block shaved) in 1 mm steps to a maximum of 6 mm. The similarity between MLC and the change in the block margin was examined by comparing the dose-volume histogram (DVH) of the normal tissues in the penumbral regions for the different setups. To correlate the effect of MLC with a change in the block margin, difference dose-volume histograms (DDVH) of the normal tissues relative to the original block were compared for the MLC setup with those for the changes in the block margin. The correlation obtained was used to predict the effect on the penumbra region of the MLC setup for the lateral fields of a patient irradiated with a four-field setup. The calculations were carried out with 15 MV x-rays. For the single field setup, dose undulation is largest for the 50% isodose line (IDL) as reflected in the largest increase in the 50% to 20% isodose region compared with the 90% to 10% and the 80% to 20% regions. The increase in the penumbral width is largest for the 20 degrees block when replaced by the MLC and is smaller as the angle increases. The increase in the penumbral width also increases with depth. The effect of replacing a Cerrobend block with an MLC is similar to an increase in the block margin. For 15 MV x-rays, the increase varies inversely with the angle of the blocks, from > 6 mm increase in block margin for the 20 degrees block to about 1 mm for the 80 degrees block. In the clinical example, replacing the blocks in the lateral fields of a four-field irradiation with MLC is similar to changing the margin of the blocks. For the posterior block, MLC is similar to a 1- to 2-mm increase in the margin of the block, whereas for the anterior block the effect is similar to 1 mm for the straight portion of the block to about 6 mm in the superior portion of the block. Characterization of an MLC setup replacing a Cerrobend block is necessary for adequate coverage of target volume. The effect of MLC replacing a Cerrobend block is similar to a change in the block margin. It is possible to estimate with reasonable accuracy the effect of MLC replacing a Cerrobend block.

journal_name

Int J Cancer

authors

Cheng CW,Das IJ,Steinberg T

doi

10.1002/ijc.1038

keywords:

subject

Has Abstract

pub_date

2001-12-20 00:00:00

pages

385-95

issue

6

eissn

0020-7136

issn

1097-0215

pii

10.1002/ijc.1038

journal_volume

96

pub_type

杂志文章
  • Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1.

    abstract::Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN-C and MMPs are often co-localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulation. To investigate whether TN-C ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11037

    authors: Kalembeyi I,Inada H,Nishiura R,Imanaka-Yoshida K,Sakakura T,Yoshida T

    更新日期:2003-05-20 00:00:00

  • Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism.

    abstract::The current paradigm stipulates that inhibition of histone deacetylase (HDAC) 6 is essential for the combinatorial effect of proteasome and HDAC inhibitors for the treatment of cancers. Our study aims to investigate the effect of combining different class I HDAC inhibitors (without HDAC6 action) with a proteasome inhi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28924

    authors: Hui KF,Chiang AK

    更新日期:2014-12-15 00:00:00

  • Monosialoganglioside biosynthesis by subcellular membranes of rhabdomyosarcoma cell lines differing in metastatic potential.

    abstract::We found that rhabdomyosarcoma (RMS) subcellular membranes contain sialyltransferase activities for LcOse4Cer and GgOse4Cer acceptors. Chromatographic analyses and neuraminidase lability of the sialyltransferase products indicated that the principal site of sialylation was the non-reducing terminal galactosyl moiety. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450531

    authors: Liepkans VA

    更新日期:1990-05-15 00:00:00

  • ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.

    abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32505

    authors: Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

    更新日期:2020-02-15 00:00:00

  • Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.

    abstract::A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25114

    authors: Goasguen N,de Chaisemartin C,Brouquet A,Julié C,Prevost GP,Laurent-Puig P,Penna C

    更新日期:2010-09-01 00:00:00

  • Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.

    abstract::The role of MHC-class-I-antigen expression in intracerebral anti-tumor natural resistance was examined using MHC-positive Lym+ and MHC-negative Lym- lymphoma cell lines. Lym+ was sensitive to MHC-class-I-restricted CTL-mediated lysis, while lym- was resistant. Both lines were susceptible to NK-cell-mediated lysis. The...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0215(19960729)67:3<365::AID-IJC

    authors: Yamasaki T,Akiyama Y,Fukuda M,Kimura Y,Moritake K,Kikuchi H,Ljunggren HG,Kärre K,Klein G

    更新日期:1996-07-29 00:00:00

  • Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide.

    abstract::Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22297

    authors: Dijkgraaf I,Kruijtzer JA,Frielink C,Corstens FH,Oyen WJ,Liskamp RM,Boerman OC

    更新日期:2007-02-01 00:00:00

  • Serological survey and virus isolation of simian T-cell leukemia/T-lymphotropic virus type I (STLV-I) in non-human primates in their native countries.

    abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910400219

    authors: Ishikawa K,Fukasawa M,Tsujimoto H,Else JG,Isahakia M,Ubhi NK,Ishida T,Takenaka O,Kawamoto Y,Shotake T

    更新日期:1987-08-15 00:00:00

  • Prognostic roles for IL-2-producing and CD69+ T cell subsets in colorectal cancer patients.

    abstract::Tumor infiltrating T cells are a predictor of patient outcome in patients with colorectal cancer (CRC). However, many T cell populations have been associated with both poor and positive patient prognoses, indicating a need to further understand the role of different T cell subsets in CRC. In this study, the T cell inf...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.31598

    authors: Taylor ES,McCall JL,Shen S,Girardin A,Munro FM,Black MA,Ward-Hartstonge KA,Kemp RA

    更新日期:2018-10-15 00:00:00

  • Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients.

    abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26365

    authors: Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

    更新日期:2012-07-01 00:00:00

  • Cytogenetic abnormalities in benign lymphoid hyperplasia: a dual-parameter study using chromosome analysis and flow cytometry.

    abstract::This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910440602

    authors: Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

    更新日期:1989-12-15 00:00:00

  • Correlation between cytogenetic data and ganglioside pattern in human meningiomas.

    abstract::Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910470303

    authors: Berra B,Papi L,Bigozzi U,Serino D,Morichi R,Mennonna P,Rapelli S,Cogliati T,Montali E

    更新日期:1991-02-01 00:00:00

  • Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes.

    abstract::The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.31381

    authors: Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

    更新日期:2018-08-01 00:00:00

  • Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells.

    abstract::Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24058

    authors: Dafou D,Ramus SJ,Choi K,Grun B,Trott DA,Newbold RF,Jacobs IJ,Jones C,Gayther SA

    更新日期:2009-03-01 00:00:00

  • Oncogenesis by interspecific interaction of malignant murine and non-malignant hamster cells in vitro.

    abstract::A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910150214

    authors: Goldenberg DM,Pavia RA

    更新日期:1975-02-15 00:00:00

  • Alcohol consumption and colon cancer prognosis among participants in north central cancer treatment group phase III trial N0147.

    abstract::Alcohol consumption is associated with a modest increased risk of colon cancer, but its relationship with colon cancer survival has not been elucidated. Using data from a phase III randomized adjuvant trial, we assessed the association of alcohol consumption with colon cancer outcomes. Patients completed a risk factor...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30135

    authors: Phipps AI,Shi Q,Limburg PJ,Nelson GD,Sargent DJ,Sinicrope FA,Chan E,Gill S,Goldberg RM,Kahlenberg M,Nair S,Shields AF,Newcomb PA,Alberts SR,Alliance for Clinical Trials in Oncology.

    更新日期:2016-09-01 00:00:00

  • Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

    abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990301)80:5<764::aid-ijc

    authors: Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

    更新日期:1999-03-01 00:00:00

  • A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPβ and OCT1 complex to chromatin.

    abstract::Recently, several studies have showed that FAS (rs2234767, rs1800682) and FASL (rs763110) functional single nucleotide polymorphisms (SNPs) were associated with the risk of various cancers. However, the association between cervical cancer risk and the three SNPs above remained inconclusive. In this work, we performed ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30490

    authors: Wu S,Wang S,Fu Y,Tang W,Jin H,Meng Q,Zhang C,Cui M,Cao X,Li X,Zhang Z,Chen R

    更新日期:2017-02-15 00:00:00

  • Trends in incidence and mortality of thyroid carcinoma in The Netherlands between 1989 and 2003: correlation with thyroid fine-needle aspiration cytology and thyroid surgery.

    abstract::A persistent increase in incidence of thyroid carcinoma (TC) has been reported worldwide. The aim of our study was to assess trends in incidence and mortality of TC in The Netherlands between 1989 and 2003 and to examine whether these trends correlate with changes in diagnostic practices such as changes in the number ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.23678

    authors: Netea-Maier RT,Aben KK,Casparie MK,den Heijer M,Grefte JM,Slootweg P,Hermus A

    更新日期:2008-10-01 00:00:00

  • Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases.

    abstract::Epstein-Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type 1. However, type-2 EBV may be involved in the pathogenesis of non-Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV-1 infection. To determine whether type-2 EBV...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910540603

    authors: De Re V,Boiocchi M,De Vita S,Dolcetti R,Gloghini A,Uccini S,Baroni C,Scarpa A,Cattoretti G,Carbone A

    更新日期:1993-07-30 00:00:00

  • Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma.

    abstract::Histone H3 lysine 9 trimethylation (H3K9me3) is associated with transcriptional repression and regulated by histone lysine methyltransferases such as SUV39H1 and ESET. However, the functional roles of these enzymes in hepatocellular carcinoma (HCC) remain uncertain. In this study, we conducted loss-of-function assays ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28985

    authors: Chiba T,Saito T,Yuki K,Zen Y,Koide S,Kanogawa N,Motoyama T,Ogasawara S,Suzuki E,Ooka Y,Tawada A,Otsuka M,Miyazaki M,Iwama A,Yokosuka O

    更新日期:2015-01-15 00:00:00

  • Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.

    abstract::Different treatment schedules have been investigated when evaluating the inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 3'-azido-2',3'-dideoxythymidine (AZT) on the replication of human immunodeficiency virus type I (HIV-I) in MT-4 cells, transformation of C3H/3T3 cells by Moloney murine sarcoma v...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910460233

    authors: Balzarini J,Naesens L,De Clercq E

    更新日期:1990-08-15 00:00:00

  • FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

    abstract::FTY720, a derivative of fungus, has demonstrated dramatic anticancer effect in several malignancies recently. Our study evaluates the therapeutic potential of FTY720 in the treatment of androgen-independent prostate cancer using a human prostate cancer xenograft in nude mice. CWR22R, an androgen-independent human pros...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.21243

    authors: Chua CW,Lee DT,Ling MT,Zhou C,Man K,Ho J,Chan FL,Wang X,Wong YC

    更新日期:2005-12-20 00:00:00

  • Comprehensive genomic landscape and precision therapeutic approach in biliary tract cancers.

    abstract::Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33230

    authors: Okamura R,Kurzrock R,Mallory RJ,Fanta PT,Burgoyne AM,Clary BM,Kato S,Sicklick JK

    更新日期:2021-02-01 00:00:00

  • Endoscopic screening for synchronous esophageal neoplasia among patients with incident head and neck cancer: Prevalence, risk factors, and outcomes.

    abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30911

    authors: Wang YK,Chuang YS,Wu TS,Lee KW,Wu CW,Wang HC,Kuo CT,Lee CH,Kuo WR,Chen CH,Wu DC,Wu IC

    更新日期:2017-11-15 00:00:00

  • Dosimetric analysis of urinary morbidity following prostate brachytherapy (125I vs. 103Pd) combined with external beam radiation therapy.

    abstract::The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10350

    authors: Chen CT,Waterman FM,Valicenti RK,Gomella LG,Strup SE,Dicker AP

    更新日期:2001-01-01 00:00:00

  • Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

    abstract::Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in 6 genes involved in the steroid hormone metabolism and signaling pathw...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ijc.24678

    authors: Udler MS,Azzato EM,Healey CS,Ahmed S,Pooley KA,Greenberg D,Shah M,Teschendorff AE,Caldas C,Dunning AM,Ostrander EA,Caporaso NE,Easton D,Pharoah PD

    更新日期:2009-12-01 00:00:00

  • Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis.

    abstract::Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.27846

    authors: Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

    更新日期:2013-04-15 00:00:00

  • Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns.

    abstract::The association between breast cancer risk defined by the Tyrer-Cuzick score (TC) and disease prognosis is not well established. Here, we investigated the relationship between 5-year TC and disease aggressiveness and then characterized underlying molecular processes. In a case-only study (n = 2474), we studied the ass...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33270

    authors: Ugalde-Morales E,Grassmann F,Humphreys K,Li J,Eriksson M,Tobin NP,Borg Å,Vallon-Christersson J,Hall P,Czene K

    更新日期:2021-02-15 00:00:00

  • Myeloid-derived suppressor cells as effectors of immune suppression in cancer.

    abstract::The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.30232

    authors: Pyzer AR,Cole L,Rosenblatt J,Avigan DE

    更新日期:2016-11-01 00:00:00