Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases.

Abstract:

:Epstein-Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type 1. However, type-2 EBV may be involved in the pathogenesis of non-Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV-1 infection. To determine whether type-2 EBV may also play a role in Hodgkin's disease (HD) developing in immunocompromised patients, we characterized EBV subtypes in EBV-positive HD samples from 10 HIV-1-positive patients as well as from a control population of 24 HIV-1-negative patients. Type-2 EBV was detected in 5/10 HD samples from the HIV-1-positive group (1 case showed concomitant type-1 EBV positivity), but only in 1/20 HD samples from the HIV-1-negative group, indicating that, during HIV-1-induced immunodepression, type-2 EBV may be pathogenetically involved also in HD, as previously reported for HIV-associated NHLs.

journal_name

Int J Cancer

authors

De Re V,Boiocchi M,De Vita S,Dolcetti R,Gloghini A,Uccini S,Baroni C,Scarpa A,Cattoretti G,Carbone A

doi

10.1002/ijc.2910540603

subject

Has Abstract

pub_date

1993-07-30 00:00:00

pages

895-8

issue

6

eissn

0020-7136

issn

1097-0215

journal_volume

54

pub_type

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