Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study.


:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Professionals Follow-Up Study from 1986 to 2004. During that time, 4,511 new PCa cases were identified. Multivariate hazard ratios (HR) were estimated using Cox regression. The HR of PCa comparing men with vs. without diabetes was 0.83 and 95% confidence interval (CI): 0.74, 0.94. PCa risk was not reduced in the first year after diabetes diagnosis (HR: 1.30, CI: 0.97, 1.72), was lower for men diagnosed for 1-6 years (HR: 0.82, CI: 0.66, 1.02), and was even lower for men who had been diagnosed for 6-15 (HR: 0.75, CI: 0.61, 0.93) or >15 years (HR: 0.78, CI: 0.63, 0.96). Reduced PCa risk was stronger in men diagnosed before 1994 (pre-PSA era) vs. after 1994. The authors also demonstrated that obese and diabetic men had a lower HR for PCa than those who were either not obese and diabetic or obese and non-diabetic. Results are consistent with the hypothesis that diabetes is associated with reduced PCa risk. Potential biological mechanisms are discussed.


Int J Cancer


Kasper JS,Liu Y,Giovannucci E




Has Abstract


2009-03-15 00:00:00












  • Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men.

    abstract::Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-mont...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Backes DM,Bleeker MC,Meijer CJ,Hudgens MG,Agot K,Bailey RC,Ndinya-Achola JO,Hayombe J,Hogewoning CJ,Moses S,Snijders PJ,Smith JS

    更新日期:2012-04-15 00:00:00

  • DT-diaphorase as a determinant of sensitivity to adriamycin in non-small-cell lung-cancer cell lines.

    abstract::We have reported the establishment of a mitomycin-C (MMC)-resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MTT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in sensitivity to etop...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kasahara K,Shibata K,Bando T,Numata Y,Fujimura M,Matsuda T

    更新日期:1994-10-15 00:00:00

  • p53 gene mutations in oropharyngeal carcinomas: a comparison of solitary and multiple primary tumours and lymph-node metastases.

    abstract::Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zariwala M,Schmid S,Pfaltz M,Ohgaki H,Kleihues P,Schäfer R

    更新日期:1994-03-15 00:00:00

  • Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses.

    abstract::The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Furumoto K,Arii S,Yamasaki S,Mizumoto M,Mori A,Inoue N,Isobe N,Imamura M

    更新日期:2000-09-01 00:00:00

  • Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.

    abstract::The aim of this study was to identify pathways that have a significant impact during renal carcinogenesis. Sixty-seven paired samples of both noncancerous renal cortex tissue and cancerous tissue from patients with clear cell renal cell carcinomas (RCCs) were subjected to whole-exome, methylome and transcriptome analy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Arai E,Sakamoto H,Ichikawa H,Totsuka H,Chiku S,Gotoh M,Mori T,Nakatani T,Ohnami S,Nakagawa T,Fujimoto H,Wang L,Aburatani H,Yoshida T,Kanai Y

    更新日期:2014-09-15 00:00:00

  • Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis.

    abstract::To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

    更新日期:2020-10-31 00:00:00

  • Birth order and risk of childhood cancer: a pooled analysis from five US States.

    abstract::The causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case-control dataset. The subjects were d...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Von Behren J,Spector LG,Mueller BA,Carozza SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin C,Puumala SE,Ross JA,Reynolds P

    更新日期:2011-06-01 00:00:00

  • Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsiveness.

    abstract::To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Larsen SS,Madsen MW,Jensen BL,Lykkesfeldt AE

    更新日期:1997-09-17 00:00:00

  • Bioactive tumour necrosis factor alpha but not granulocyte-macrophage colony-stimulating factor correlates inversely with Langerhans's cell numbers in skin tumours.

    abstract::Langerhans' cells (LCs) are thought to play an important role in presentation of tumour antigens for the induction of anti-tumour immunity. Epidermis overlying some transplanted murine skin tumours contains increased numbers of LCs; however, alterations in LC numbers are not related to tumour antigenicity or host immu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rubel DM,Barnetson RS,Halliday GM

    更新日期:1998-01-19 00:00:00

  • Human papillomavirus types in cervical dysplasia among young HPV-vaccinated women: Population-based nested case-control study.

    abstract::Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cervical cancer. We investigated whether development of cervical intraepithelial neoplasia (CIN) lesions in HPV-vaccinated women is associated with vaccine-targeted HPV types o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kann H,Hortlund M,Eklund C,Dillner J,Faust H

    更新日期:2020-05-01 00:00:00

  • Childhood cancer incidence in Queensland, 1979-88.

    abstract::Data on the incidence of childhood cancer in Queensland during the 10-year period 1979-88 are presented. During this period, 786 cases were registered. The average annual crude and age-standardized (to the world population) incidence rates for both sexes were 12.63 and 13.30 per 100,000 respectively. The incidence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McWhirter WR,Petroeschevsky AL

    更新日期:1990-06-15 00:00:00

  • Induction of gamma-glutamyltranspeptidase-positive altered hepatocytic lesions by combination of transplacental-initiation and postanal-selection.

    abstract::The purpose of this study was to induce in postnatal life the selective growth of altered hepatocytic populations which had been induced in utero by various chemicals. Pregnant rats of a Wistar strain were given a single dose of various chemical carcinogens on the 18th gestational day. From two months postpartum, both...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ogawa K,Yokokawa K,Tomoyori T,Onoé T

    更新日期:1982-03-15 00:00:00

  • Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease.

    abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

    更新日期:2007-09-15 00:00:00

  • In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.

    abstract::We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

    更新日期:1995-04-10 00:00:00

  • Natural killer cell activity associated with reticulum cell neoplasms.

    abstract::A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chang KS,Log T

    更新日期:1980-03-15 00:00:00

  • No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.

    abstract::Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

    更新日期:2010-12-01 00:00:00

  • Hepatitis C virus 1b is the dominant genotype in HCV-related carcinogenesis: a case-control study.

    abstract::In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

    更新日期:1996-09-27 00:00:00

  • Contrasting effects of 17 beta-estradiol on the growth of human ovarian carcinoma cells in vitro and in vivo.

    abstract::A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Langdon SP,Ritchie A,Young K,Crew AJ,Sweeting V,Bramley T,Hillier S,Hawkins RA,Tesdale AL,Smyth JF

    更新日期:1993-09-30 00:00:00

  • Evaluation of cell survival, DNA double strand breaks, and DNA synthesis during concurrent camptothecin and X-radiation treatments.

    abstract::We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ng CE,Mazaheri K,Payant C,Raaphorst GP

    更新日期:2001-10-20 00:00:00

  • Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma.

    abstract::Urinary bladder cancer is a heterogeneous disease with tumors ranging from papillary noninvasive (stage Ta) to solid muscle infiltrating tumors (stage T2+). The risk of progression and death for the most frequent diagnosed type, Ta, is low, but the high incidence of recurrences has a significant effect on the patients...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nord H,Segersten U,Sandgren J,Wester K,Busch C,Menzel U,Komorowski J,Dumanski JP,Malmström PU,Díaz de Ståhl T

    更新日期:2010-03-15 00:00:00

  • Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously.

    abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Belardelli F,Gresser I,Maury C,Duvillard P,Prade M,Maunoury MT

    更新日期:1983-05-15 00:00:00

  • Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study.

    abstract::Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sipos B,Weber D,Ungefroren H,Kalthoff H,Zühlsdorff A,Luther C,Török V,Klöppel G

    更新日期:2002-12-20 00:00:00

  • Characterization of a small-cell-lung-carcinoma cell line from a patient with cancer-associated retinopathy.

    abstract::We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

    更新日期:1996-03-01 00:00:00

  • The epstein-Barr-virus-encoded membrane protein LMP but not the nuclear antigen EBNA-1 induces rejection of transfected murine mammary carcinoma cells.

    abstract::The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was te...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trivedi P,Masucci MG,Winberg G,Klein G

    更新日期:1991-07-09 00:00:00

  • Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines.

    abstract::The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Caca K,Feisthammel J,Klee K,Tannapfel A,Witzigmann H,Wittekind C,Mössner J,Berr F

    更新日期:2002-02-01 00:00:00

  • Automated diagnosis of pigmented skin lesions.

    abstract::Since advanced melanoma remains practically incurable, early detection is an important step toward a reduction in mortality. High expectations are entertained for a technique known as dermoscopy or epiluminescence light microscopy; however, evaluation of pigmented skin lesions by this method is often extremely complex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rubegni P,Cevenini G,Burroni M,Perotti R,Dell'Eva G,Sbano P,Miracco C,Luzi P,Tosi P,Barbini P,Andreassi L

    更新日期:2002-10-20 00:00:00

  • p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.

    abstract::Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Quan H,Xu Y,Lou L

    更新日期:2008-04-15 00:00:00

  • Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study.

    abstract::We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Martró E,Esteve A,Schulz TF,Sheldon J,Gambús G,Muñoz R,Whitby D,Casabona J,Euro-Shaks study group.

    更新日期:2007-03-01 00:00:00

  • Evaluation of CA 125 as a serum marker of hepatocellular carcinoma.

    abstract::Serum CA 125 concentrations were raised in 90.4% of 115 southern African black patients with hepatocellular carcinoma. Seventy-four percent of 62 patients with amebic hepatic abscess, 60% of 40 patients with chronic hepatic parenchymal disease (chronic hepatitis or cirrhosis), and 60.9% of 41 patients with acute viral...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Elias J,Kew MC

    更新日期:1990-11-15 00:00:00

  • Risk of lung cancer among cigarette and pipe smokers in southern China.

    abstract::Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other method...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

    更新日期:1992-05-28 00:00:00