Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitro.

abstract：:Epidemiological studies of in situ breast cancer are sparse, and the role of reproductive history, an established risk modifier for invasive breast cancer, remains incompletely investigated. To examine possible associations with parity and age at first birth, we undertook a case-control study nested in a nationwide co...

journal_title：International journal of cancer

authors： Lambe M,Hsieh CC,Tsaih SW,Ekbom A,Trichopoulos D,Adami HO

更新日期：1998-07-29 00:00:00

abstract：:CD43 is a leukocyte-associated sialoglycoprotein which is also expressed in human colon adenoma and carcinoma. To obtain monoclonal antibodies (MAbs) that would react with CD43 in a glycosylation-independent way, antibodies were raised against a peptide corresponding to a portion of the CD43 cytoplasmic domain. Hybrid...

journal_title：International journal of cancer

authors： Sikut R,Andersson CX,Sikut A,Fernandez-Rodriguez J,Karlsson NG,Hansson GC

更新日期：1999-07-02 00:00:00

abstract：:To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...

journal_title：International journal of cancer

authors： Larsen SS,Madsen MW,Jensen BL,Lykkesfeldt AE

更新日期：1997-09-17 00:00:00

abstract：:Both the tumour growth and progression and the systemic inflammatory response have the potential to increase oxidative stress. We therefore examined the relationship between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n = 53...

journal_title：International journal of cancer

authors： Leung EY,Crozier JE,Talwar D,O'Reilly DS,McKee RF,Horgan PG,McMillan DC

更新日期：2008-11-15 00:00:00

abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

journal_title：International journal of cancer

authors： Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

更新日期：2011-09-15 00:00:00

abstract：:During the 7th annual follow-up of our cohort of homosexual men in 1989, we tested the hypotheses that infection with human immunodeficiency virus (HIV) may enhance the expression of human papilloma virus (HPV) and that the development of anal epithelial abnormality is related to a biologic interaction between these t...

journal_title：International journal of cancer

authors： Caussy D,Goedert JJ,Palefsky J,Gonzales J,Rabkin CS,DiGioia RA,Sanchez WC,Grossman RJ,Colclough G,Wiktor SZ

更新日期：1990-08-15 00:00:00

abstract：:Polymorphism of DNA base excision repair (BER) genes affects DNA repair capacity and may alter sensitivity to platinum-based chemotherapy regimens. This study investigated polymorphisms of OGG1 Ser326Cys, APE1 Asp148Glu APE1-141T/G and XRCC1 Arg399Gln for association with clinical outcome in 235 advanced inoperable no...

journal_title：International journal of cancer

authors： Peng Y,Li Z,Zhang S,Xiong Y,Cun Y,Qian C,Li M,Ren T,Xia L,Cheng Y,Wang D

更新日期：2014-12-01 00:00:00

abstract：:The neural crest gives rise to a variety of tissues, including peripheral neurons, Schwann cells, melanocytes and ectomesenchymal cells, which include the smooth-muscle cells of large arteries. Cell lines derived from neuroblastoma (a neural-crest tumor) exhibit at least 2 distinct morphological cell types, a neurobla...

journal_title：International journal of cancer

authors： Sugimoto T,Ueyama H,Hosoi H,Inazawa J,Kato T,Kemshead JT,Reynolds CP,Gown AM,Mine H,Sawada T

更新日期：1991-05-10 00:00:00

abstract：:In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...

journal_title：International journal of cancer

authors： Hombach A,Jung W,Pohl C,Renner C,Sahin U,Schmits R,Wolf J,Kapp U,Diehl V,Pfreundschuh M

更新日期：1993-11-11 00:00:00

abstract：:Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...

journal_title：International journal of cancer

authors： Ward HA,Murphy N,Weiderpass E,Leitzmann MF,Aglago E,Gunter MJ,Freisling H,Jenab M,Boutron-Ruault MC,Severi G,Carbonnel F,Kühn T,Kaaks R,Boeing H,Tjønneland A,Olsen A,Overvad K,Merino S,Zamora-Ros R,Rodríguez-Barranc

更新日期：2019-09-15 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:Colorectal cancer (CRC) screening rates are currently suboptimal. Blood-based screening could improve rates of earlier detection for CRC and adenomatous colorectal polyps. In this study, we evaluated the feasibility of plasma-based detection of early CRC and adenomatous polyps using array-mediated analysis methylation...

journal_title：International journal of cancer

authors： Cassinotti E,Melson J,Liggett T,Melnikov A,Yi Q,Replogle C,Mobarhan S,Boni L,Segato S,Levenson V

更新日期：2012-09-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

journal_title：International journal of cancer

authors： Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

更新日期：2008-03-15 00:00:00

abstract：:To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 was evaluated by methylation-specific polymerase chain reaction in 92...

journal_title：International journal of cancer

authors： Dong CX,Deng DJ,Pan KF,Zhang L,Zhang Y,Zhou J,You WC

更新日期：2009-01-15 00:00:00

abstract：:Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

journal_title：International journal of cancer

authors： Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

更新日期：1992-04-01 00:00:00

abstract：:Although heparin can regulate angiogenesis, tumor growth and metastasis, its clinical application, as well as that of low-molecular heparin (LMWH), for treating cancer are limited because of heparin's anticoagulant activity and risk of hemorrhages. LMWH-taurocholate conjugates (LHT7), which have low anticoagulant acti...

journal_title：International journal of cancer

authors： Lee E,Kim YS,Bae SM,Kim SK,Jin S,Chung SW,Lee M,Moon HT,Jeon OC,Park RW,Kim IS,Byun Y,Kim SY

更新日期：2009-06-15 00:00:00

abstract：:Proteins can be detected by South-western analyses of human tumour-cell extracts binding to double-stranded oligonucleotide DNA treated in vitro with the chemotherapeutic drug cis-diamminedichloroplatinum (II) (CDDP), but not to untreated DNA. The relative molecular masses of proteins binding to the CDDP-treated doubl...

journal_title：International journal of cancer

authors： McLaughlin K,Coren G,Masters J,Brown R

更新日期：1993-02-20 00:00:00

abstract：:The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...

journal_title：International journal of cancer

authors： Gima T,Kato H,Honda T,Imamura T,Sasazuki T,Wake N

更新日期：1994-05-15 00:00:00

abstract：:Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

journal_title：International journal of cancer

authors： Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

更新日期：2012-03-01 00:00:00

abstract：:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

journal_title：International journal of cancer

authors： Hawkins MM,Smith RA

更新日期：1989-03-15 00:00:00

abstract：:Aberrant methylation of CpG islands (CGI) not only plays a role in gene silencing, but is also a potential cancer biomarker. To identify more CGI aberrantly methylated in human breast cancers, we carried out a genome-wide search for aberrant methylation, using methylation-sensitive-representational difference analysis...

journal_title：International journal of cancer

authors： Miyamoto K,Fukutomi T,Akashi-Tanaka S,Hasegawa T,Asahara T,Sugimura T,Ushijima T

更新日期：2005-09-01 00:00:00

abstract：:XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

journal_title：International journal of cancer

authors： Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

更新日期：2003-01-01 00:00:00

abstract：:The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...

journal_title：International journal of cancer

authors： Beau-Faller M,Gaub MP,Schneider A,Ducrocq X,Massard G,Gasser B,Chenard MP,Kessler R,Anker P,Stroun M,Weitzenblum E,Pauli G,Wihlm JM,Quoix E,Oudet P

更新日期：2003-06-20 00:00:00

abstract：:Emerging evidence suggests that the transcription factor Forkhead Box M1 (FoxM1) is associated with aggressive human carcinomas, including breast cancer. Because elevated expression of FoxM1 has been observed in human breast cancers, FoxM1 has attracted much attention in recent years as a potential target for the prev...

journal_title：International journal of cancer

authors： Ahmad A,Ali S,Wang Z,Ali AS,Sethi S,Sakr WA,Raz A,Rahman KM

更新日期：2011-10-01 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influen...

journal_title：International journal of cancer

authors： An Y,Yang Q

更新日期：2020-11-24 00:00:00

abstract：:Tumor cell motility is one of the rate-limiting steps of invasion, which defines progression toward a more malignant phenotype. Elevated expression of epidermal growth factor receptor (EGFR) in many cancers is associated with progression of superficial to invasive forms of the disease. The naturally occuring type III ...

journal_title：International journal of cancer

authors： Pedersen MW,Tkach V,Pedersen N,Berezin V,Poulsen HS

更新日期：2004-02-20 00:00:00

abstract：:Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...

journal_title：International journal of cancer

authors： Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

更新日期：2005-01-01 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in l...

journal_title：International journal of cancer

authors： Gao Y,Goldstein AM,Consonni D,Pesatori AC,Wacholder S,Tucker MA,Caporaso NE,Goldin L,Landi MT

更新日期：2009-07-01 00:00:00

abstract：:Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, RASSF1A located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the status of RASSF1A in cervical cancers. ...

journal_title：International journal of cancer

authors： Yu MY,Tong JH,Chan PK,Lee TL,Chan MW,Chan AW,Lo KW,To KF

更新日期：2003-06-10 00:00:00