Abstract:
:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death rates in migrrants, by country of origin, sex, age, and duration of residence in Australia (less than or equal to 16 years and greater than 16 years), have been calculated for 1962-76, and compared with those of the Australian-born population. All seven migrant source countries, in 1970, had higher rates of stomach cancer than Australia, and the corresponding migrants groups, which initially reflected those higher rates, experienced an approximately 25% risk reduction with increased duration of residence. For cancer of the pancreas, migrants initially had rates well above their "native" rates; with longer stay, the risks generally converged upon that of the Australian-born population. The four "continental" (European) migrant groups, whose native risk of colon cancer is about half that of the Australian population, showed an increased risk with increasing duration of stay. The increase was greater in men than in women, perhaps reflecting their greater dietary acculturation. By contrast, Scottish migrants, with an initially high risk of cigrants showed even larger increases than colon cancer, while in British migrants there was a marked decline towards the "Australian-borne" risk. These various changes in cancer risk are discussed with reference to inter-country dietary differences.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
McMichael AJ,McCall MG,Hartshorne JM,Woodings TLdoi
10.1002/ijc.2910250402subject
Has Abstractpub_date
1980-04-15 00:00:00pages
431-7issue
4eissn
0020-7136issn
1097-0215journal_volume
25pub_type
杂志文章abstract::Metastasis to the liver often occurs in patients during the natural course of pancreatic cancer. Using carcinoma cell lines established from 9 such patients, we examined phenotypes of cell lines to search for correlations with their potential to metastasize to the liver. Anti-asialo GMI-treated nude mice were used. PC...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960822)69:4<290::AID-IJC
更新日期:1996-08-22 00:00:00
abstract::Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease, suggesting that additional host genetic alterations are necessary for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22335
更新日期:2007-01-15 00:00:00
abstract::This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23499
更新日期:2008-07-15 00:00:00
abstract::A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340504
更新日期:1984-11-15 00:00:00
abstract::The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26305
更新日期:2012-06-01 00:00:00
abstract::In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550405
更新日期:1993-10-21 00:00:00
abstract::Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29558
更新日期:2015-10-15 00:00:00
abstract::661 bp coding for the carboxyl end of the large sub-unit of EBV ribonucleotide reductase was cloned into the pMal plasmid vector. Purified recombinant protein was tested in IgG and IgA ELISAs. For the IgG assay, 81 out of 100 NPC patients tested positive, whereas for the IgA assay, 60 tested positive. Among 100 normal...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590604
更新日期:1994-12-15 00:00:00
abstract::People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32895
更新日期:2020-06-01 00:00:00
abstract::After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29833
更新日期:2016-02-15 00:00:00
abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11049
更新日期:2003-06-10 00:00:00
abstract::DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32962
更新日期:2020-09-15 00:00:00
abstract::Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Störkel based on the ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550210
更新日期:1993-09-09 00:00:00
abstract::Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25859
更新日期:2011-10-15 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior. Recent studies suggested that high expression of the antiapoptotic protein survivin might be associated with adverse outcome in oral cancer patients. To investigate, whether increased ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22380
更新日期:2007-02-15 00:00:00
abstract::An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-ini...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600321
更新日期:1995-01-27 00:00:00
abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28204
更新日期:2013-10-15 00:00:00
abstract::This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550112
更新日期:1993-08-19 00:00:00
abstract::Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking-related cancer. We investigated the association between the -93G-->A polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20359
更新日期:2004-11-20 00:00:00
abstract::Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320109
更新日期:1983-07-15 00:00:00
abstract::A herpesvirus (RhEBV) was isolated from a lymphoblastoid cell line (LCL) that became established from a malignant lymphoma in a rhesus monkey. The predominant cell marker in the LCL was that of B lymphocytes. RhEBV-induced viral capsid (VCA) and nuclear antigens (NA) in the LCL were serologically related to similar an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380319
更新日期:1986-09-15 00:00:00
abstract::The expression of a gastrointestinal carcinoma-associated antigen (GICA), a monosialoganglioside, was investigated in tissues from human fetuses of various gestational ages (10-40 weeks). Mouse monoclonal antibody NS-19-9, generated in mice immunized with SW1116 human colon carcinoma cells, was used along with a secon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340208
更新日期:1984-08-15 00:00:00
abstract::Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550429
更新日期:1993-10-21 00:00:00
abstract::Cancer-related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31977
更新日期:2019-05-15 00:00:00
abstract::It is well known that the functions of reproductive organs are regulated by sex steroids and their receptors and it is hypothesized that the progression of neoplasms that originate from the reproductive organs is influenced by them. However, the correlation between sex steroids and tumor progression, especially tumor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10504
更新日期:2002-08-01 00:00:00
abstract::XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA -4G>A polymorphism was identified in the 5' noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA ...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.26391
更新日期:2012-07-15 00:00:00
abstract::Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30517
更新日期:2017-04-01 00:00:00
abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370207
更新日期:1986-02-15 00:00:00
abstract::Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10690
更新日期:2002-11-20 00:00:00
abstract::Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30625
更新日期:2017-05-01 00:00:00