Acceleration of invasive activity via matrix metalloproteinases by transfection of the estrogen receptor-alpha gene in endometrial carcinoma cells.


:It is well known that the functions of reproductive organs are regulated by sex steroids and their receptors and it is hypothesized that the progression of neoplasms that originate from the reproductive organs is influenced by them. However, the correlation between sex steroids and tumor progression, especially tumor invasion, is not well known in endometrial carcinoma. In our study, we focused on the influence of estrogen and its receptor in invasion and matrix metalloproteinases (MMPs), which are known to be important in tumor invasion, as well as on endometrial carcinoma cells. The growth of Ishikawa cells, to which an estrogen receptor-alpha expressing vector was transfected, was accelerated by 17 beta-estradiol as was the acceleration of the expression of cyclin D1. By invasion assay, in conditions with 17 beta-estradiol, the invasiveness of Ishikawa cells was enhanced. Furthermore, according to the accelerated invasiveness, the expression of MMP-1, -7 and -9 and Ets-1 was enhanced. These results suggest that activation of ER-alpha by estrogen results in tumor progression by stimulating cell growth and invasiveness via acceleration of the expression of MMPs.


Int J Cancer


Mizumoto H,Saito T,Ashihara K,Nishimura M,Tanaka R,Kudo R





Has Abstract


2002-08-01 00:00:00












  • Low frequency of BRAF and CDKN2A mutations in endometrial cancer.

    abstract::Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for activation of the RAS signalling pathway. The CDKN2A (p16) tumour suppressor gene is also altered in several tumour types. We therefore wanted to assess the patte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Salvesen HB,Kumar R,Stefansson I,Angelini S,MacDonald N,Smeds J,Jacobs IJ,Hemminki K,Das S,Akslen LA

    更新日期:2005-07-20 00:00:00

  • Body size and composition and colon cancer risk in women.

    abstract::Studies of colon cancer risk in males have reported strong positive associations with obesity, particularly with central adiposity. The association has been weaker and less consistent for women. In a prospective cohort study of women, body measurements were taken directly; fat mass and fat-free mass being estimated by...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: MacInnis RJ,English DR,Hopper JL,Gertig DM,Haydon AM,Giles GG

    更新日期:2006-03-15 00:00:00

  • Prescription drug use and risk of acute myeloid leukemia by French-American-British subtype: results from a Los Angeles County case-control study.

    abstract::Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pogoda JM,Katz J,McKean-Cowdin R,Nichols PW,Ross RK,Preston-Martin S

    更新日期:2005-04-20 00:00:00

  • Drug-resistant human bladder-cancer cells are more sensitive to adenovirus-mediated wild-type p53 gene therapy compared to drug-sensitive cells.

    abstract::We investigated the therapeutic potential and molecular mechanism of adenovirus-mediated wt p53 gene therapy for drug-resistant human bladder cancers. KK47, a human bladder-cancer cell line, along with the drug-resistant sublines KK47/DDP10, KK47/DDP20 (cisplatin-resistant) and KK47/ADM (doxorubicin-resistant) were us...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shirakawa T,Sasaki R,Gardner TA,Kao C,Zhang ZJ,Sugimura K,Matsuo M,Kamidono S,Gotoh A

    更新日期:2001-10-15 00:00:00

  • Melanoma in Western Australia 1975-76 to 1980-81: trends in demographic and pathological characteristics.

    abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: English DR,Heenan PJ,Holman CD,Armstrong BK,Blackwell JB,Kelsall GR,Matz LR,Singh A,ten Seldam RE

    更新日期:1986-02-15 00:00:00

  • Direct comparison of liquid-based and conventional cytology in a South African screening trial.

    abstract::Our study directly compares the performance of liquid-based (LBC) and conventional cytology for detecting high-grade cervical intraepithelial neoplasia and cancer (CIN 2+) in high-risk, previously unscreened women. As part of a larger randomized clinical trial assessing the efficacy and safety of a "screen and treat" ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Taylor S,Kuhn L,Dupree W,Denny L,De Souza M,Wright TC Jr

    更新日期:2006-02-15 00:00:00

  • Autocrine/paracrine erythropoietin signalling promotes JAK/STAT-dependent proliferation of human cervical cancer cells.

    abstract::Erythropoietin (Epo) regulates erythropoiesis by binding to its receptor (EpoR) and promoting cell proliferation, differentiation and inhibition of apoptosis. Epo is widely used to treat cervical cancer-related anaemia. However, there are data suggesting that administration of Epo is associated with an increment in re...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lopez TV,Lappin TR,Maxwell P,Shi Z,Lopez-Marure R,Aguilar C,Rocha-Zavaleta L

    更新日期:2011-12-01 00:00:00

  • Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.

    abstract::3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McDougall JK,Galloway DA,Fenoglio CM

    更新日期:1980-01-15 00:00:00

  • Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: Analysis in real-life settings.

    abstract::Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tak KY,Nam HC,Choi JY,Yoon SK,Kim CW,Kim HY,Lee SW,Lee HL,Chang UI,Song DS,Yang JM,Kwon JH,Yoo SH,Sung PS,Choi SW,Song MJ,Kim SH,Jang JW

    更新日期:2020-10-01 00:00:00

  • Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer.

    abstract::Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

    更新日期:2001-06-01 00:00:00

  • Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease.

    abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

    更新日期:2007-09-15 00:00:00

  • Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.

    abstract::TAAs of the MAGE family are mostly studied as targets of specific immune responses. Their potential relevance as tumor markers has also been underlined. We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kocher T,Zheng M,Bolli M,Simon R,Forster T,Schultz-Thater E,Remmel E,Noppen C,Schmid U,Ackermann D,Mihatsch MJ,Gasser T,Heberer M,Sauter G,Spagnoli GC

    更新日期:2002-08-20 00:00:00

  • miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis.

    abstract::Glioblastoma multiforme (GBM) is the most lethal brain malignancy which involves multi-gene abnormality. Unfortunately, effective therapy against GBM remains lacking. Previously, we found that NRP-1 and its downstream NRP-1/GIPC1 pathway played an important role in GBM. In our study, we further investigated the upstre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang G,Chen L,Khan AA,Li B,Gu B,Lin F,Su X,Yan J

    更新日期:2018-08-01 00:00:00

  • Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer.

    abstract::We have quantified the expression of all 4 isoforms of vascular endothelial growth factor (VEGF) mRNA in non-small-cell lung cancer (NSCLC) using a new kinetic quantitative PCR method, real-time quantitative (RTQ) RT-PCR, and investigated the association between VEGF expression at the mRNA and protein levels and the c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yuan A,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT,Yang PC

    更新日期:2000-11-20 00:00:00

  • Differential inducibility of Epstein-Barr virus in cloned, non-producer Raji cells.

    abstract::Cells of the human lymphoblastoid non-producer line Raji were cloned in soft agar. Individual colonies were isolated and analyzed for their inducibility of the Epstein-Barr virus-associated early antigen (EA). The induction of EA by the tumor promoter TPA varied among the different cell clones. Clones with very high a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bister K,Yamamoto N,zur Hausen H

    更新日期:1979-06-15 00:00:00

  • Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

    abstract::It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Davies M,Paterson IC,Ganapathy A,Prime SS

    更新日期:2006-12-15 00:00:00

  • High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers.

    abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

    更新日期:2016-01-01 00:00:00

  • Meta-iodobenzylguanidine induces growth inhibition and apoptosis of neuroendocrine gastrointestinal tumor cells.

    abstract::Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Höpfner M,Sutter AP,Beck NI,Barthel B,Maaser K,Jockers-Scherübl MC,Zeitz M,Scherübl H

    更新日期:2002-09-20 00:00:00

  • Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.

    abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS

    更新日期:2018-05-15 00:00:00

  • Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitro.

    abstract::Cryopreserved tumour cells obtained from the ascitic fluid of a patient with an ovarian carcinoma were employed to determine the effect on in vitro drug cytotoxicities of varying both drug concentration and exposure time. Four antitumour drugs, in common clinical usage, were selected for study. Tumour-cell survival fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rupniak HT,Whelan RD,Hill BT

    更新日期:1983-07-15 00:00:00

  • Interleukin-2-stimulated natural killer activity against malignant and benign endometrium.

    abstract::Natural cell-mediated immunity against autologous tumor cells, autologous endometrial epithelium, and allogeneic epidermoid carcinoma cell line HeLa was tested in 8 patients with endometrial carcinoma and one patient with endometrial stromal sarcoma. The average cytotoxicity of unstimulated peripheral blood lymphocyte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Timonen T,Lehtovirta P,Saksela E

    更新日期:1987-10-15 00:00:00

  • Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.

    abstract::Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

    更新日期:2005-08-10 00:00:00

  • Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic MAb MK2-23. Immunohistochemical analysis of the reactivity of anti-anti-idiotypic MAb with surgically removed melanoma lesions.

    abstract::The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kageshita T,Hirai S,Ono T,Ferrone S

    更新日期:1995-01-27 00:00:00

  • Cytolytic activity against tumor cells by macrophage cell lines and augmentation by macrophage stimulants.

    abstract::Previous studies have shown that macrophage cell lines retained the ability to phagocytize, to secrete lysosomal enzymes, and to function as effector cells in antibody-dependent cellular cytoxicity. In this paper, the cytolytic activity of murine macrophage cell lines against tumor target cells was assessed using an 1...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Taniyama T,Holden HT

    更新日期:1980-07-15 00:00:00

  • RNA-reverse transcriptase complex from cultured human myeloma-leukemia cells.

    abstract::A high molecular weight RNA-reverse transcriptase complex in the culture media of peripheral leukocytes obtained from two Japanese patients with myeloma-leukemia was detected by demonstration of a 3H-uridine peak and a peak of DNA polymerizing activity banding at a density of 1.15-1.19g/ml. The enzyme in the complex w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sawada H,Tashima M,Nakamura T,Uchiyama T,Sagawa K,Takatsuki K,Uchino H,Ito Y

    更新日期:1977-07-15 00:00:00

  • NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation.

    abstract::In previous reports, systemic administration of a stimulatory monoclonal antibody directed against the 4-1BB receptor had no effect on survival or tumor burden in mice inoculated with the poorly immunogenic B16-F10 melanoma. We combined IL-12 gene transfer with 4-1BB costimulation to explore a previously noted coopera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu D,Gu P,Pan PY,Li Q,Sato AI,Chen SH

    更新日期:2004-04-20 00:00:00

  • Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumour lymphatic-homing peptide LyP-1.

    abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

    更新日期:2009-05-01 00:00:00

  • Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.

    abstract::A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Goasguen N,de Chaisemartin C,Brouquet A,Julié C,Prevost GP,Laurent-Puig P,Penna C

    更新日期:2010-09-01 00:00:00

  • DNA repair phenotype and cancer susceptibility--a mini review.

    abstract::DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Li C,Wang LE,Wei Q

    更新日期:2009-03-01 00:00:00

  • E-selectin binding by pancreatic tumor cells is inhibited by cancer sera.

    abstract::Tumor cells interact with endothelial cells during both intra- and extravasation. Understanding how these interactions are modulated could lead to the development of ways to alter the metastatic potential of tumor cells. Three pancreatic cancer cell lines, SW1990, CAPAN-2 and PANC-I, were examined for their ability to...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sawada T,Ho JJ,Chung YS,Sowa M,Kim YS

    更新日期:1994-06-15 00:00:00