PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality.

abstract：:Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extracellular form in gynecologic ca...

journal_title：International journal of cancer

authors： Korneeva I,Caputo TA,Witkin SS

更新日期：2002-12-10 00:00:00

abstract：:Tissue factor (TF)-mediated protease-activated receptor (PAR)-2 signaling is associated with a promigratory, invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these ...

journal_title：International journal of cancer

authors： Rydén L,Grabau D,Schaffner F,Jönsson PE,Ruf W,Belting M

更新日期：2010-05-15 00:00:00

abstract：:Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain r...

journal_title：International journal of cancer

authors： Ieta K,Tanaka F,Yokobori T,Kita Y,Haraguchi N,Mimori K,Kato H,Asao T,Inoue H,Kuwano H,Mori M

更新日期：2009-08-15 00:00:00

abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...

journal_title：International journal of cancer

authors： Collins RJ,Morgan LD,Owen S,Ruge F,Jiang WG,Sanders AJ

更新日期：2018-11-15 00:00:00

abstract：:Emerging evidence suggests that the transcription factor Forkhead Box M1 (FoxM1) is associated with aggressive human carcinomas, including breast cancer. Because elevated expression of FoxM1 has been observed in human breast cancers, FoxM1 has attracted much attention in recent years as a potential target for the prev...

journal_title：International journal of cancer

authors： Ahmad A,Ali S,Wang Z,Ali AS,Sethi S,Sakr WA,Raz A,Rahman KM

更新日期：2011-10-01 00:00:00

abstract：:The effects of bromodeoxyuridine (BrdUrd) incorporation into hepatocytes of carbon tetrachloride (CCl4)-induced regenerating liver of BALB/c mice on the induction of endogenous retroviruses was examined. From the nucliec acid hybridization studies, the maximum levels of hybridization were obtained for both N- and X-tr...

journal_title：International journal of cancer

authors： Ayukawa HM,Saltzburg D,Mukherjee BB

更新日期：1979-10-15 00:00:00

abstract：:Hodgkin and Reed-Sternberg (H and RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such cells are found only in a minority of HD lesions. Very few data have so far been published on the cytogenetic abnormalities in HD. An analysis of unknown genetic aberrations has only...

journal_title：International journal of cancer

authors： Ohshima K,Ishiguro M,Ohgami A,Sugihara M,Haraoka S,Suzumiya J,Kikuchi M

更新日期：1999-07-19 00:00:00

abstract：:Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

journal_title：International journal of cancer

authors： Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

更新日期：2015-03-01 00:00:00

abstract：:The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...

journal_title：International journal of cancer

authors： Rodeberg DA,Wharam MD,Lyden ER,Stoner JA,Brown K,Wolden SL,Paidas CN,Donaldson SS,Hawkins DS,Spunt SL,Arndt CA

更新日期：2015-07-01 00:00:00

abstract：:A high molecular weight RNA-reverse transcriptase complex in the culture media of peripheral leukocytes obtained from two Japanese patients with myeloma-leukemia was detected by demonstration of a 3H-uridine peak and a peak of DNA polymerizing activity banding at a density of 1.15-1.19g/ml. The enzyme in the complex w...

journal_title：International journal of cancer

authors： Sawada H,Tashima M,Nakamura T,Uchiyama T,Sagawa K,Takatsuki K,Uchino H,Ito Y

更新日期：1977-07-15 00:00:00

abstract：:Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function is thought to participa...

journal_title：International journal of cancer

authors： Ibrahim EC,Aractingi S,Allory Y,Borrini F,Dupuy A,Duvillard P,Carosella ED,Avril MF,Paul P

更新日期：2004-01-10 00:00:00

abstract：:Data are limited regarding cancer risk in human immunodeficiency virus (HIV)-infected persons with modest immunosuppression, before the onset of acquired immunodeficiency syndrome (AIDS). For some cancers, risk may be affected by highly active antiretroviral therapy (HAART) widely available since 1996. We linked HIV/A...

journal_title：International journal of cancer

authors： Engels EA,Biggar RJ,Hall HI,Cross H,Crutchfield A,Finch JL,Grigg R,Hylton T,Pawlish KS,McNeel TS,Goedert JJ

更新日期：2008-07-01 00:00:00

abstract：:Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathol...

journal_title：International journal of cancer

authors： Mandahl N,Akerman M,Aman P,Dal Cin P,De Wever I,Fletcher CD,Mertens F,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van den Berghe H,Van de Ven W,Vanni R,Willén H

更新日期：1996-09-04 00:00:00

abstract：:Novel classes of drug that interfere with the signalling of the small G-protein Ras, the so-called Ras antagonists, are showing much promise as novel anti-cancer agents. In this study, we demonstrate that the novel Ras antagonist farnesylthiosalicylic acid (FTS) inhibits the growth of Colo 853 melanoma cells through a...

journal_title：International journal of cancer

authors： Smalley KS,Eisen TG

更新日期：2002-04-01 00:00:00

abstract：:We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...

journal_title：International journal of cancer

authors： Kabashima A,Higuchi H,Takaishi H,Matsuzaki Y,Suzuki S,Izumiya M,Iizuka H,Sakai G,Hozawa S,Azuma T,Hibi T

更新日期：2009-06-15 00:00:00

abstract：:Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer...

journal_title：International journal of cancer

authors： Ferlay J,Colombet M,Soerjomataram I,Mathers C,Parkin DM,Piñeros M,Znaor A,Bray F

更新日期：2019-04-15 00:00:00

abstract：:The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...

journal_title：International journal of cancer

authors： Nguyen QM,Nguyen HC,Parkin DM

更新日期：1998-05-18 00:00:00

abstract：:In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...

journal_title：International journal of cancer

authors： Strohsnitter WC,Bertrand KA,Troisi R,Scott CG,Cheville AL,Hoover RN,Palmer JR,Vachon CM

更新日期：2018-09-15 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

journal_title：International journal of cancer

authors： Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

更新日期：2003-05-01 00:00:00

abstract：:The effect of serum from mice bearing methylcholanthrene-induced fibrosarcomas on the lympho-proliferative responses of their spleen and lymph-node cells to 3 M KCl-solubilized tumor antigens has been investigated. Low concentrations of serum (less than or equal to 2.5%) collected throughout the course of tumor growth...

journal_title：International journal of cancer

authors： Calderwood MB,Forbes JT,Smith RT

更新日期：1977-09-15 00:00:00

abstract：:Combining the specificity of tumor-targeting bacteria with the sensitivity of biomarker detection would create a screening method able to detect small tumors and metastases. To create this system, we genetically modified an attenuated strain of Salmonella enterica to release a recombinant fluorescent biomarker (or flu...

journal_title：International journal of cancer

authors： Panteli JT,Van Dessel N,Forbes NS

更新日期：2020-01-01 00:00:00

abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...

journal_title：International journal of cancer

authors： Baade PD,Whiteman DC,Janda M,Cust AE,Neale RE,Smithers BM,Green AC,Khosrotehrani K,Mar V,Soyer HP,Aitken JF

更新日期：2020-09-01 00:00:00

abstract：:We have used immunoprecipitation to test tumor biopsies and normal adult and fetal human tissues for p97, a tumor-associated protein. Five of nine melanoma biopsies contained p97 in low to very high levels. Three of seven non-melanoma tumors contained p97, but in smaller amounts. No p97 was detected in any of the norm...

journal_title：International journal of cancer

authors： Woodbury RG,Brown JP,Loop SM,Hellström KE,Hellström I

更新日期：1981-02-15 00:00:00

abstract：:Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...

journal_title：International journal of cancer

authors： Monferran S,Skuli N,Delmas C,Favre G,Bonnet J,Cohen-Jonathan-Moyal E,Toulas C

更新日期：2008-07-15 00:00:00

abstract：:Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Ill...

journal_title：International journal of cancer

authors： Kettunen E,Hernandez-Vargas H,Cros MP,Durand G,Le Calvez-Kelm F,Stuopelyte K,Jarmalaite S,Salmenkivi K,Anttila S,Wolff H,Herceg Z,Husgafvel-Pursiainen K

更新日期：2017-11-15 00:00:00

abstract：:The calcium-sensing receptor (CaSR) is suggested to mediate the antiproliferative effects of calcium in colon. However, in colorectal cancer (CRC) the expression of the CaSR is silenced and the underlying mechanisms leading to its loss are poorly understood. We investigated whether loss of the CaSR expression in color...

journal_title：International journal of cancer

authors： Fetahu IS,Höbaus J,Aggarwal A,Hummel DM,Tennakoon S,Mesteri I,Baumgartner-Parzer S,Kállay E

更新日期：2014-11-01 00:00:00

abstract：:Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...

journal_title：International journal of cancer

authors： Sarkar S,Dutta D,Samanta SK,Bhattacharya K,Pal BC,Li J,Datta K,Mandal C,Mandal C

更新日期：2013-02-01 00:00:00

abstract：:Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...

journal_title：International journal of cancer

authors： García-Sanz R,González-Fraile MI,Mateo G,Hernández JM,López-Berges MC,de las Heras N,Fernández-Calvo J,Ortega F,Portero JA,Bárez A,Galende J,Orfão A,San Miguel JF

更新日期：2004-12-10 00:00:00

abstract：:Squamous cell carcinoma of the esophagus has an uneven geographic distribution, with a high incidence in the Transkei region of Eastern Cape Province, South Africa. The precise molecular events associated with tumorigenesis of esophageal cancer in this region have not been characterized. DNA from human esophageal squa...

journal_title：International journal of cancer

authors： Gamieldien W,Victor TC,Mugwanya D,Stepien A,Gelderblom WC,Marasas WF,Geiger DH,van Helden PD

更新日期：1998-11-23 00:00:00

abstract：:By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns of uptake and biolocalization of 5-aminolevulinic acid (ALA)-induced porphyrins in s.c. transplanted tumors, adjacent normal skin and muscle, and liver of mice bearing mammary carcinoma, after i.p. ...

journal_title：International journal of cancer

authors： Peng Q,Moan J,Warloe T,Nesland JM,Rimington C

更新日期：1992-09-30 00:00:00